(Q42319599)

English

Rationally designed PKA inhibitors for positron emission tomography: Synthesis and cerebral biodistribution of N-(2-(4-bromocinnamylamino)ethyl)-N-[11C]methyl-isoquinoline-5-sulfonamide.

scientific article published on 6 March 2008

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18346896%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

Rationally designed PKA inhibitors for positron emission tomography: Synthesis and cerebral biodistribution of N-(2-(4-bromocinnamylamino)ethyl)-N-[11C]methyl-isoquinoline-5-sulfonamide (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18346896%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

positron emission tomography

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inferred from title

James R. Woodgett

3

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4 January 2020

7

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4 January 2020

author name string

Neil Vasdev

1

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4 January 2020

Frank J LaRonde

2

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4 January 2020

Armando Garcia

4

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4 January 2020

Elizabeth A Rubie

5

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4 January 2020

Jeffrey H Meyer

6

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4 January 2020

Alan A Wilson

8

1 reference

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4 January 2020

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publication date

6 March 2008

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4 January 2020

Bioorganic & Medicinal Chemistry

1 reference

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4 January 2020

16

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4 January 2020

9

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4 January 2020

5277-5284

1 reference

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4 January 2020

A structural comparison of inhibitor binding to PKB, PKA and PKA-PKB chimera

1 reference

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25 October 2017

Molecular recognition of protein kinase binding pockets for design of potent and selective kinase inhibitors

1 reference

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25 October 2017

Chemoprevention with protein kinase A RIalpha antisense in DMBA-mammary carcinogenesis

1 reference

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25 October 2017

Tumor reversion: protein kinase A isozyme switching

1 reference

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25 October 2017

Structure-based design of isoquinoline-5-sulfonamide inhibitors of protein kinase B.

1 reference

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25 October 2017

Dynamics of signaling by PKA.

1 reference

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25 October 2017

Determination of lipophilicity and its use as a predictor of blood-brain barrier penetration of molecular imaging agents

1 reference

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25 October 2017

Predicting the success of a radiopharmaceutical for in vivo imaging of central nervous system neuroreceptor systems

1 reference

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25 October 2017

Toward a PKB inhibitor: modification of a selective PKA inhibitor by rational design

1 reference

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25 October 2017

Protein kinases--the major drug targets of the twenty-first century?

1 reference

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25 October 2017

An admonition when measuring the lipophilicity of radiotracers using counting techniques

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5328674

25 October 2017

Specificity in the cAMP/PKA signaling pathway. Differential expression,regulation, and subcellular localization of subunits of PKA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5328674

25 October 2017

A molecular and cellular theory of depression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5328674

25 October 2017

Crystal structures of catalytic subunit of cAMP-dependent protein kinase in complex with isoquinolinesulfonyl protein kinase inhibitors H7, H8, and H89. Structural implications for selectivity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5328674

25 October 2017

In vivo evaluation of [11C]- and [18F]-labelled cocaine analogues as potential dopamine transporter ligands for positron emission tomography.

1 reference

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29 May 2018

Evaluation of kemptide, a synthetic serine-containing heptapeptide, as a phosphate acceptor for the estimation of cyclic AMP-dependent protein kinase activity in respiratory tissues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5328674

29 May 2018

Membrane trapping of carbon-11-labeled 1,2-diacylglycerols as a basic concept for assessing phosphatidylinositol turnover in neurotransmission process

1 reference

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29 May 2018

Synthesis and ex vivo evaluation of carbon-11 labelled N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea ([11C]AR-A014418): a radiolabelled glycogen synthase kinase-3beta specific inhibitor for PET studies.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5328674

17 August 2018

MicroPET detection of enhanced 18F-FDG utilization by PKA inhibitor in awake rat brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5328674

17 August 2018

Protein kinase A in postmortem brain of depressed suicide victims: altered expression of specific regulatory and catalytic subunits

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5328674

17 August 2018

Brain incorporation of [11C]arachidonic acid in young healthy humans measured with positron emission tomography

1 reference

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17 August 2018

Imaging cAMP-specific phosphodiesterase-4 in human brain with R-[11C]rolipram and positron emission tomography.

1 reference

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17 August 2018

Radiotracer synthesis from [(11)C]-iodomethane: a remarkably simple captive solvent method.

1 reference

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17 August 2018

Evaluation of phosphoinositide turnover on ischemic human brain with 1-[1-11C]-butyryl-2-palmitoyl-rac-glycerol using PET.

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17 August 2018

Imaging of cAMP-specific phosphodiesterase-IV: comparison of [11C]rolipram and [11C]Ro 20-1724 in rats.

1 reference

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17 August 2018

Protein kinase C imaging using carbon-11-labeled phorbol esters: 12-deoxyphorbol 13-isobutyrate-20-[1-11C]butyrate as the potential ligand for positron emission tomography.

1 reference

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17 August 2018

5-Isoquinolinesulfonamide derivatives. 1. Synthesis and vasodilatory activity of N-(2-guanidinoethyl)-5-isoquinolinesulfonamide derivatives

1 reference

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inferred from PubMed ID database lookup

Carbon-11-forskolin: a ligand for visualization of the adenylate cyclase-related second messenger system

1 reference

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Antioxidant-based inhibitors of leukotriene biosynthesis. The discovery of 6-[1-[2-(hydroxymethyl)phenyl]-1-propen-3-yl]-2,3-dihydro-5- benzofuranol, a potent topical antiinflammatory agent

1 reference

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inferred from PubMed ID database lookup

[(3)H]cAMP binding sites and protein kinase a activity in the prefrontal cortex of suicide victims

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drug discovery process for kinase inhibitors

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.BMC.2008.03.013

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Europe PubMed Central

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4 January 2020

PMC publication ID

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18346896%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18346896%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

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