(Q42463764)

English

In vitro and in vivo characterization of JNJ-31020028 (N-(4-{4-[2-(diethylamino)-2-oxo-1-phenylethyl]piperazin-1-yl}-3-fluorophenyl)-2-pyridin-3-ylbenzamide), a selective brain penetrant small molecule antagonist of the neuropeptide Y Y(2) receptor

scientific article published on 2 December 2009

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

1 November 2017

In vitro and in vivo characterization of JNJ-31020028 (N-(4-{4-[2-(diethylamino)-2-oxo-1-phenylethyl]piperazin-1-yl}-3-fluorophenyl)-2-pyridin-3-ylbenzamide), a selective brain penetrant small molecule antagonist of the neuropeptide Y Y(2) receptor (English)

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1 November 2017

author name string

James R Shoblock

1

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1 November 2017

Natalie Welty

2

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1 November 2017

Diane Nepomuceno

3

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1 November 2017

Brian Lord

4

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1 November 2017

Leah Aluisio

5

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1 November 2017

Ian Fraser

6

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1 November 2017

S Timothy Motley

7

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1 November 2017

Steve W Sutton

8

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1 November 2017

Kirsten Morton

9

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1 November 2017

Ruggero Galici

10

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1 November 2017

John R Atack

11

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1 November 2017

Lisa Dvorak

12

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1 November 2017

Devin M Swanson

13

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1 November 2017

Nicholas I Carruthers

14

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1 November 2017

Curt Dvorak

15

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1 November 2017

Timothy W Lovenberg

16

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1 November 2017

Pascal Bonaventure

17

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1 November 2017

publication date

2 December 2009

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1 November 2017

number of pages

13

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inferred from page(s)

Psychopharmacology

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1 November 2017

208

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1 November 2017

2

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1 November 2017

265-277

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1 November 2017

Characterization of N-(1-Acetyl-2,3-dihydro-1H-indol-6-yl)-3-(3-cyano-phenyl)-N-[1-(2-cyclopentyl-ethyl)-piperidin-4yl]acrylamide (JNJ-5207787), a small molecule antagonist of the neuropeptide Y Y2 receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/19953226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Continuous intraventricular infusion of neuropeptide Y evokes episodic food intake in satiated female rats: effects of adrenalectomy and cholecystokinin

1 reference

https://pubmed.ncbi.nlm.nih.gov/19953226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced anxiety and improved stress coping ability in mice lacking NPY-Y2 receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/19953226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of a selective neuropeptide Y Y(2) receptor antagonist, BIIE0246 on neuropeptide Y release

1 reference

https://pubmed.ncbi.nlm.nih.gov/19953226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of neuropeptide Y, Y(2) receptor knockout mice in two animal models of learning and memory processing

1 reference

https://pubmed.ncbi.nlm.nih.gov/19953226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced anxiety-like and depression-related behavior in neuropeptide Y Y4 receptor knockout mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19953226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anxiolytic-like effect of the selective neuropeptide Y Y2 receptor antagonist BIIE0246 in the elevated plus-maze

1 reference

https://pubmed.ncbi.nlm.nih.gov/19953226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuropeptide Y5 receptor antagonism does not induce clinically meaningful weight loss in overweight and obese adults

1 reference

https://pubmed.ncbi.nlm.nih.gov/19953226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacological validation of a novel animal model of anticipatory anxiety in mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19953226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuropeptide Y in normal eating and in genetic and dietary-induced obesity

1 reference

https://pubmed.ncbi.nlm.nih.gov/19953226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential distribution of neuropeptide Y Y1 and Y2 receptors in rat and guinea-pig brains

1 reference

https://pubmed.ncbi.nlm.nih.gov/19953226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased expression of the gene for the Y1 receptor of neuropeptide Y in the amygdala and paraventricular nucleus of Y1R/LacZ transgenic mice in response to restraint stress.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19953226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anxiolytic-like effect of neuropeptide Y (NPY) and NPY13-36 microinjected into vicinity of locus coeruleus in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/19953226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The NPY system in stress, anxiety and depression

1 reference

https://pubmed.ncbi.nlm.nih.gov/19953226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuropeptide y: role in emotion and alcohol dependence

1 reference

https://pubmed.ncbi.nlm.nih.gov/19953226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypothalamic Y2 Receptors: Central Coordination of Energy Homeostasis and Bone Mass Regulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19953226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression cloning of a human brain neuropeptide Y Y2 receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/19953226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of NPY mRNA-expressing cells in the human brain: co-localization with Y2 but not Y1 mRNA in the cerebral cortex, hippocampus, amygdala, and striatum

1 reference

https://pubmed.ncbi.nlm.nih.gov/19953226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differentially functionalized diamines as novel ligands for the NPY2 receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/19953226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuropeptide Y acts directly in the periphery on fat tissue and mediates stress-induced obesity and metabolic syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/19953226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Locus coeruleus neurons in the rat containing neuropeptide Y, tyrosine hydroxylase or galanin and their efferent projections to the spinal cord, cerebral cortex and hypothalamus

1 reference

https://pubmed.ncbi.nlm.nih.gov/19953226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Suppression of ethanol self-administration by the neuropeptide Y (NPY) Y2 receptor antagonist BIIE0246: evidence for sensitization in rats with a history of dependence

1 reference

https://pubmed.ncbi.nlm.nih.gov/19953226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autoradiographic distribution of [125I]Leu31,Pro34]PYY and [125I]PYY3-36 binding sites in the rat brain evaluated with two newly developed Y1 and Y2 receptor radioligands.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19953226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CCK and NPY as anti-anxiety treatment targets: promises, pitfalls, and strategies

1 reference

https://pubmed.ncbi.nlm.nih.gov/19953226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Assessment of ethanol consumption and water drinking by NPY Y(2) receptor knockout mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/19953226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of a selective antagonist of neuropeptide Y at the Y2 receptor. Synthesis and pharmacological evaluation of a Y2 antagonist

1 reference

https://pubmed.ncbi.nlm.nih.gov/19953226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impaired angiogenesis in neuropeptide Y (NPY)-Y2 receptor knockout mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/19953226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential plasma catecholamine and neuropeptide Y responses to acute stress in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/19953226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NPY Y1 and Y5 receptor selective antagonists as anti-obesity drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/19953226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BIIE0246: a selective and high affinity neuropeptide Y Y(2) receptor antagonist

1 reference

https://pubmed.ncbi.nlm.nih.gov/19953226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuropeptide Y (NPY) Y2 receptors mediate behaviour in two animal models of anxiety: evidence from Y2 receptor knockout mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/19953226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Region-specific inhibition of potassium-evoked [3H]noradrenaline release from rat brain synaptosomes by neuropeptide Y-(13-36). Involvement of NPY receptors of the Y2 type

1 reference

https://pubmed.ncbi.nlm.nih.gov/19953226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stimulation of neuropeptide Y-mediated calcium responses in human SMS-KAN neuroblastoma cells endogenously expressing Y2 receptors by co-expression of chimeric G proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/19953226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BIIE0246, a potent and highly selective non-peptide neuropeptide Y Y(2) receptor antagonist

1 reference

https://pubmed.ncbi.nlm.nih.gov/19953226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00213-009-1726-X

1 reference

Europe PubMed Central

PubMed publication ID

1 November 2017

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PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

1 November 2017

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