(Q42467584)

1 November 2017

PI3-kinase regulates survival of chronic lymphocytic leukemia B-cells by preventing caspase 8 activation (English)

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chronic lymphocytic leukemia

1 November 2017

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1 reference

1 reference

Janet M D Plate

1

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1 November 2017

1 August 2004

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1 November 2017

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1 November 2017

45

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1 November 2017

8

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1 November 2017

1519-1529

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Gene expression in chronic lymphocytic leukemia B cells and changes during induction of apoptosis

1 November 2017

1 reference

https://api.crossref.org/works/10.1080%2F10428190410001683642

Gene expression profiling of B cell chronic lymphocytic leukemia reveals a homogeneous phenotype related to memory B cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190410001683642

Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190410001683642

Cellular survival: a play in three Akts

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190410001683642

Involvement of protein kinase C and phosphatidylinositol 3-kinase pathways in the survival of B-cell chronic lymphocytic leukemia cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190410001683642

Constitutively activated phosphatidylinositol-3 kinase (PI-3K) is involved in the defect of apoptosis in B-CLL: association with protein kinase Cdelta.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190410001683642

Caspases signal not only apoptosis but also antigen-induced activation in cells of the immune system

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190410001683642

An induced proximity model for caspase-8 activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190410001683642

Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190410001683642

Caspase 8 activation independent of Fas (CD95/APO-1) signaling may mediate killing of B-chronic lymphocytic leukemia cells by cytotoxic drugs or gamma radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190410001683642

The triterpenoid CDDO induces apoptosis in refractory CLL B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190410001683642

Apoptosis and interleukin 7 gene expression in chronic B-lymphocytic leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190410001683642

Regulation of Akt/PKB activation by tyrosine phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190410001683642

Syk and Bruton's tyrosine kinase are required for B cell antigen receptor-mediated activation of the kinase Akt.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190410001683642

The tyrosine kinases Syk and Lyn exert opposing effects on the activation of protein kinase Akt/PKB in B lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190410001683642

Tyrosine phosphorylation of B-cell adaptor for phosphoinositide 3-kinase is required for Akt activation in response to CD19 engagement

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190410001683642

Forkhead transcription factors: new insights into protein kinase B (c-akt) signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190410001683642

Glycogen synthase kinase-3 beta activity is critical for neuronal death caused by inhibiting phosphatidylinositol 3-kinase or Akt but not for death caused by nerve growth factor withdrawal.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190410001683642

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190410001683642

PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190410001683642

Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190410001683642

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190410001683642

Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-Kinase/Akt cell survival pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190410001683642

Lithium inhibits caspase 3 activation and dephosphorylation of PKB and GSK3 induced by K+ deprivation in cerebellar granule cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190410001683642

PPP2R1BGene in Chronic Lymphocytic Leukemias and Mantle Cell Lymphomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190410001683642

Lithium inhibits glycogen synthase kinase-3 by competition for magnesium.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190410001683642

A molecular mechanism for the effect of lithium on development

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190410001683642

CREB DNA binding activity is inhibited by glycogen synthase kinase-3 beta and facilitated by lithium

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190410001683642

Lithium blocks the PKB and GSK3 dephosphorylation induced by ceramide through protein phosphatase-2A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190410001683642

NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190410001683642

NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190410001683642

c-FLIP(L) is a dual function regulator for caspase-8 activation and CD95-mediated apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190410001683642

Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190410001683642

Regulation of cell death protease caspase-9 by phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190410001683642

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190410001683642

Phosphatidylinositol 3-kinase/Akt activity regulates c-FLIP expression in tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190410001683642

Targets of B-cell antigen receptor signaling: the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase-3 signaling pathway and the Rap1 GTPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190410001683642

Human chronic lymphocytic leukemia modeled in mouse by targeted TCL1 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190410001683642

The protooncogene TCL1 is an Akt kinase coactivator

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190410001683642

Tcl1 enhances Akt kinase activity and mediates its nuclear translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190410001683642

Identification of a plasma membrane Raft-associated PKB Ser473 kinase activity that is distinct from ILK and PDK1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190410001683642

Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190410001683642

Alterations of the PPP2R1B gene in human lung and colon cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190410001683642

Akt is more than just a Bad kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190410001683642

10.1080/10428190410001683642

21 January 2018

Identifiers

DOI

1 reference

1 November 2017

1 reference

PubMed ID

15370202