(Q42478854)

1 November 2017

title

Accumulation of distinct prelamin A variants in human diploid fibroblasts differentially affects cell homeostasis (English)

1 reference

1 November 2017

Jose Candelario

1

1 reference

1 November 2017

Stacey Borrego

series ordinal

2

1 reference

1 November 2017

Sita Reddy

series ordinal

3

1 reference

1 November 2017

Lucio Comai

series ordinal

4

1 reference

1 November 2017

language of work or name

English

0 references

publication date

23 October 2010

1 reference

Experimental Cell Research

1 November 2017

published in

1 reference

1 November 2017

volume

317

1 reference

1 November 2017

issue

3

1 reference

1 November 2017

page(s)

319-329

1 reference

Nuclear lamins: building blocks of nuclear architecture

1 November 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.10.014

Isoprenylation is required for the processing of the lamin A precursor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.10.014

Nucleoplasmic localization of prelamin A: implications for prenylation-dependent lamin A assembly into the nuclear lamina

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.10.014

"Laminopathies": a wide spectrum of human diseases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.10.014

Hutchinson-Gilford progeria syndrome

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.10.014

Lamin a truncation in Hutchinson-Gilford progeria.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.10.014

Recurrent de novo point mutations in lamin A cause Hutchinson–Gilford progeria syndrome

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.10.014

Inhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford progeria syndrome

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.10.014

Incomplete processing of mutant lamin A in Hutchinson-Gilford progeria leads to nuclear abnormalities, which are reversed by farnesyltransferase inhibition

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.10.014

Inhibiting farnesylation reverses the nuclear morphology defect in a HeLa cell model for Hutchinson-Gilford progeria syndrome

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.10.014

Blocking protein farnesyltransferase improves nuclear shape in fibroblasts from humans with progeroid syndromes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.10.014

Perturbation of wild-type lamin A metabolism results in a progeroid phenotype

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.10.014

The mutant form of lamin A that causes Hutchinson-Gilford progeria is a biomarker of cellular aging in human skin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.10.014

Lamin A-dependent nuclear defects in human aging

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.10.014

Accelerated telomere shortening and replicative senescence in human fibroblasts overexpressing mutant and wild-type lamin A.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.10.014

Aging of Hutchinson-Gilford progeria syndrome fibroblasts is characterised by hyperproliferation and increased apoptosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.10.014

Identification and biochemical characterization of a Werner's syndrome protein complex with Ku70/80 and poly(ADP-ribose) polymerase-1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.10.014

Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson-Gilford progeria syndrome

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.10.014

Failure of lamin A/C to functionally assemble in R482L mutated familial partial lipodystrophy fibroblasts: altered intermolecular interaction with emerin and implications for gene transcription

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.10.014

Alteration of nuclear lamin organization inhibits RNA polymerase II-dependent transcription

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.10.014

Lamin A/C speckles mediate spatial organization of splicing factor compartments and RNA polymerase II transcription

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.10.014

Prelamin A acts to accelerate smooth muscle cell senescence and is a novel biomarker of human vascular aging

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.10.014

Defective DSB repair correlates with abnormal nuclear morphology and is improved with FTI treatment in Hutchinson-Gilford progeria syndrome fibroblasts

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.10.014

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.10.014

Tethering by lamin A stabilizes and targets the ING1 tumour suppressor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.10.014

Pre-Lamin A processing is linked to heterochromatin organization.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.10.014

Blocking protein farnesyltransferase improves nuclear blebbing in mouse fibroblasts with a targeted Hutchinson-Gilford progeria syndrome mutation.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.10.014

An accumulation of non-farnesylated prelamin A causes cardiomyopathy but not progeria

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.10.014

A protein farnesyltransferase inhibitor ameliorates disease in a mouse model of progeria.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.10.014

Direct synthesis of lamin A, bypassing prelamin a processing, causes misshapen nuclei in fibroblasts but no detectable pathology in mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.10.014

10.1016/J.YEXCR.2010.10.014

7 January 2021

Identifiers

DOI

1 reference

1 November 2017

1 reference