(Q42490775)

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An increase in basal BDNF provokes hyperactivation of the Akt-mammalian target of rapamycin pathway and deregulation of local dendritic translation in a mouse model of Down's syndrome.

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21715609%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

An increase in basal BDNF provokes hyperactivation of the Akt-mammalian target of rapamycin pathway and deregulation of local dendritic translation in a mouse model of Down's syndrome (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21715609%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

1 reference

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Alexandra Alves Sampaio

2

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21715609%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

María Luz Montesinos

3

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21715609%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

author name string

José Antonio Troca-Marín

1

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21715609%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

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publication date

1 June 2011

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21715609%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Journal of Neuroscience

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21715609%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

31

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21715609%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

26

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21715609%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

9445-9455

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21715609%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

FKBP12-Rapamycin-associated Protein (FRAP) Autophosphorylates at Serine 2481 under Translationally Repressive Conditions

1 reference

https://pubmed.ncbi.nlm.nih.gov/21715609

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synapsins as mediators of BDNF-enhanced neurotransmitter release

1 reference

https://pubmed.ncbi.nlm.nih.gov/21715609

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain-derived neurotrophic factor (BDNF) induces dendritic targeting of BDNF and tyrosine kinase B mRNAs in hippocampal neurons through a phosphatidylinositol-3 kinase-dependent pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/21715609

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chemical stimulation of synaptosomes modulates alpha -Ca2+/calmodulin-dependent protein kinase II mRNA association to polysomes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21715609

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dendritic anomalies in disorders associated with mental retardation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21715609

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus

1 reference

https://pubmed.ncbi.nlm.nih.gov/21715609

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selectivity in neurotrophin signaling: theme and variations

1 reference

https://pubmed.ncbi.nlm.nih.gov/21715609

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Upstream and downstream of mTOR

1 reference

https://pubmed.ncbi.nlm.nih.gov/21715609

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BDNF regulates the translation of a select group of mRNAs by a mammalian target of rapamycin-phosphatidylinositol 3-kinase-dependent pathway during neuronal development.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21715609

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chromosome 21 and down syndrome: from genomics to pathophysiology

1 reference

https://pubmed.ncbi.nlm.nih.gov/21715609

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain-derived neurotrophic factor induces mammalian target of rapamycin-dependent local activation of translation machinery and protein synthesis in neuronal dendrites

1 reference

https://pubmed.ncbi.nlm.nih.gov/21715609

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BDNF-induced recruitment of TrkB receptor into neuronal lipid rafts: roles in synaptic modulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21715609

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age-related changes in brain-derived neurotrophic factor and tyrosine kinase receptor isoforms in the hippocampus and hypothalamus in male rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/21715609

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abnormal synaptic plasticity in the Ts1Cje segmental trisomy 16 mouse model of Down syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/21715609

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

To BDNF or not to BDNF: that is the epileptic hippocampus

1 reference

https://pubmed.ncbi.nlm.nih.gov/21715609

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of dendritic morphogenesis by Ras-PI3K-Akt-mTOR and Ras-MAPK signaling pathways.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21715609

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Control of dendritic arborization by the phosphoinositide-3'-kinase-Akt-mammalian target of rapamycin pathway.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21715609

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The chemical biology of clinically tolerated NMDA receptor antagonists

1 reference

https://pubmed.ncbi.nlm.nih.gov/21715609

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo restoration of physiological levels of truncated TrkB.T1 receptor rescues neuronal cell death in a trisomic mouse model.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21715609

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered signaling pathways underlying abnormal hippocampal synaptic plasticity in the Ts65Dn mouse model of Down syndrome.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21715609

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting mammalian target of rapamycin (mTOR) for health and diseases.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21715609

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain-derived neurotrophic factor regulates cholesterol metabolism for synapse development

1 reference

https://pubmed.ncbi.nlm.nih.gov/21715609

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synaptic and cognitive abnormalities in mouse models of Down syndrome: exploring genotype-phenotype relationships

1 reference

https://pubmed.ncbi.nlm.nih.gov/21715609

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acute injections of the NMDA receptor antagonist memantine rescue performance deficits of the Ts65Dn mouse model of Down syndrome on a fear conditioning test.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21715609

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dendritic mRNA: transport, translation and function

1 reference

https://pubmed.ncbi.nlm.nih.gov/21715609

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Seizure Disorders in Down Syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/21715609

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein synthesis and neurotrophin-dependent structural plasticity of single dendritic spines.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21715609

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroscience. A protoplasmic kiss to remember

1 reference

https://pubmed.ncbi.nlm.nih.gov/21715609

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reversal of learning deficits in a Tsc2+/- mouse model of tuberous sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21715609

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distinct role of long 3' UTR BDNF mRNA in spine morphology and synaptic plasticity in hippocampal neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/21715609

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence that protein constituents of postsynaptic membrane specializations are locally synthesized: analysis of proteins synthesized within synaptosomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/21715609

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The self-tuning neuron: synaptic scaling of excitatory synapses

1 reference

https://pubmed.ncbi.nlm.nih.gov/21715609

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Excitatory-inhibitory relationship in the fascia dentata in the Ts65Dn mouse model of Down syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/21715609

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuronal release of proBDNF.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21715609

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The "Down syndrome critical region" is sufficient in the mouse model to confer behavioral, neurophysiological, and synaptic phenotypes characteristic of Down syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/21715609

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BDNF activates mTOR to regulate GluR1 expression required for memory formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21715609

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New insights into the role of brain-derived neurotrophic factor in synaptic plasticity

1 reference

https://pubmed.ncbi.nlm.nih.gov/21715609

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BDNF signaling in the formation, maturation and plasticity of glutamatergic and GABAergic synapses.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21715609

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Local translation of dendritic RhoA revealed by an improved synaptoneurosome preparation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21715609

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dysregulation of mTOR signaling in fragile X syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/21715609

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age-related changes in plasma levels of BDNF in Down syndrome patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/21715609

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of long-term memantine on memory and neuropathology in Ts65Dn mice, a model for Down syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/21715609

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Memantine normalizes several phenotypic features in the Ts65Dn mouse model of Down syndrome.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21715609

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytoplasmic polyadenylation element-like sequences are involved in dendritic targeting of BDNF mRNA in hippocampal neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/21715609

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of local translation at the synapse by BDNF.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21715609

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NMDA-mediated regulation of DSCAM dendritic local translation is lost in a mouse model of Down's syndrome.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21715609

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BDNF and NT-4/5 enhance glutamatergic synaptic transmission in cultured hippocampal neurones

1 reference

https://pubmed.ncbi.nlm.nih.gov/21715609

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular mapping of twenty-four features of Down syndrome on chromosome 21.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21715609

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain-derived neurotrophic factor rapidly enhances phosphorylation of the postsynaptic N-methyl-D-aspartate receptor subunit 1

1 reference

https://pubmed.ncbi.nlm.nih.gov/21715609

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotrophin modulation of NMDA receptors in cultured murine and isolated rat neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21715609

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activity-dependent dendritic targeting of BDNF and TrkB mRNAs in hippocampal neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21715609

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BDNF acutely increases tyrosine phosphorylation of the NMDA receptor subunit 2B in cortical and hippocampal postsynaptic densities

1 reference

https://pubmed.ncbi.nlm.nih.gov/21715609

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain-derived neurotrophic factor modulates hippocampal synaptic transmission by increasing N-methyl-D-aspartic acid receptor activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/21715609

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transport of brain-derived neurotrophic factor across the blood-brain barrier.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21715609

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.0011-11.2011

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21715609%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21715609%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21715609%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

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