(Q42492466)

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The accumulation of un-repairable DNA damage in laminopathy progeria fibroblasts is caused by ROS generation and is prevented by treatment with N-acetyl cysteine

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scholarly article

1 reference

Europe PubMed Central

1 November 2017

The accumulation of un-repairable DNA damage in laminopathy progeria fibroblasts is caused by ROS generation and is prevented by treatment with N-acetyl cysteine (English)

1 reference

Europe PubMed Central

1 November 2017

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author name string

Shane A Richards

1

1 reference

Europe PubMed Central

1 November 2017

Joanne Muter

2

1 reference

Europe PubMed Central

1 November 2017

Pamela Ritchie

3

1 reference

Europe PubMed Central

1 November 2017

Giovanna Lattanzi

4

1 reference

Europe PubMed Central

1 November 2017

Christopher J Hutchison

5

1 reference

Europe PubMed Central

1 November 2017

publication date

1 August 2011

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Europe PubMed Central

1 November 2017

Human Molecular Genetics

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Europe PubMed Central

1 November 2017

20

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Europe PubMed Central

1 November 2017

20

1 reference

Europe PubMed Central

1 November 2017

3997-4004

1 reference

Europe PubMed Central

1 November 2017

Nuclear lamins: laminopathies and their role in premature ageing.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR327

21 January 2018

Recurrent de novo point mutations in lamin A cause Hutchinson–Gilford progeria syndrome

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR327

21 January 2018

Lamin a truncation in Hutchinson-Gilford progeria.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR327

21 January 2018

LMNA mutations in atypical Werner's syndrome

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR327

21 January 2018

Loss of ZMPSTE24 (FACE-1) causes autosomal recessive restrictive dermopathy and accumulation of Lamin A precursors.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR327

21 January 2018

Mandibuloacral dysplasia is caused by a mutation in LMNA-encoding lamin A/C

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR327

21 January 2018

Recent advances in the study of prenylated proteins

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR327

21 January 2018

Prelamin A endoproteolytic processing in vitro by recombinant Zmpste24

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR327

21 January 2018

Blocking protein farnesyltransferase improves nuclear shape in fibroblasts from humans with progeroid syndromes

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR327

21 January 2018

Inhibiting farnesylation reverses the nuclear morphology defect in a HeLa cell model for Hutchinson-Gilford progeria syndrome

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR327

21 January 2018

Inhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford progeria syndrome

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR327

21 January 2018

Incomplete processing of mutant lamin A in Hutchinson-Gilford progeria leads to nuclear abnormalities, which are reversed by farnesyltransferase inhibition

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR327

21 January 2018

A farnesyltransferase inhibitor improves disease phenotypes in mice with a Hutchinson-Gilford progeria syndrome mutation.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR327

21 January 2018

Genomic instability in laminopathy-based premature aging

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR327

21 January 2018

Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR327

21 January 2018

Expression of disease-causing lamin A mutants impairs the formation of DNA repair foci

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR327

21 January 2018

The R527H mutation in LMNA gene causes an increased sensitivity to ionizing radiation

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR327

21 January 2018

DNA damage responses in progeroid syndromes arise from defective maturation of prelamin A.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR327

21 January 2018

Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR327

21 January 2018

Involvement of xeroderma pigmentosum group A (XPA) in progeria arising from defective maturation of prelamin A.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR327

21 January 2018

The R439C mutation in LMNA causes lamin oligomerization and susceptibility to oxidative stress

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR327

21 January 2018

Human cell senescence as a DNA damage response.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR327

21 January 2018

Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR327

21 January 2018

gamma-H2AX dephosphorylation by protein phosphatase 2A facilitates DNA double-strand break repair

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR327

21 January 2018

Role of H2O2 in RET/PTC1 chromosomal rearrangement produced by ionizing radiation in human thyroid cells

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR327

21 January 2018

Laminopathies and the long strange trip from basic cell biology to therapy

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR327

21 January 2018

New approaches to progeria

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR327

21 January 2018

Assessing the efficacy of protein farnesyltransferase inhibitors in mouse models of progeria

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR327

21 January 2018

Progerin elicits disease phenotypes of progeria in mice whether or not it is farnesylated.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR327

21 January 2018

Reversal of age-dependent nuclear morphology by inhibition of prenylation does not affect lifespan in Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR327

21 January 2018

Protein farnesylation inhibitors cause donut-shaped cell nuclei attributable to a centrosome separation defect

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR327

21 January 2018

Effect of progerin on the accumulation of oxidized proteins in fibroblasts from Hutchinson Gilford progeria patients

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR327

21 January 2018

Laminopathies and atherosclerosis

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR327

21 January 2018

Atorvastatin acts synergistically with N-acetyl cysteine to provide therapeutic advantage against Fas-activated erythrocyte apoptosis during chronic arsenic exposure in rats

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR327

21 January 2018

Identifiers

10.1093/HMG/DDR327

1 reference

Europe PubMed Central

1 November 2017

1 reference

Europe PubMed Central

1 November 2017

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