(Q42503570)

1 November 2017

title

Contacts between extracellular loop two and transmembrane helix six determine basal activity of the thyroid-stimulating hormone receptor (English)

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1 November 2017

main subject

transmembrane protein

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author

Maren Claus

2

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1 November 2017

Gunnar Kleinau

1

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1 November 2017

Holger Jaeschke

3

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1 November 2017

Sandra Mueller

4

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1 November 2017

Susanne Neumann

5

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1 November 2017

Ralf Paschke

6

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1 November 2017

Gerd Krause

7

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1 November 2017

language of work or name

English

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publication date

1 November 2006

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Journal of Biological Chemistry

1 November 2017

published in

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1 November 2017

volume

282

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1 November 2017

issue

1

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1 November 2017

page(s)

518-525

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Thyroid-stimulating hormone and thyroid-stimulating hormone receptor structure-function relationships

1 November 2017

cites work

1 reference

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Thyrotropin receptor-associated diseases: from adenomata to Graves disease

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Evidence that the C terminus of the A subunit suppresses thyrotropin receptor constitutive activity

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Evaluation of small-molecule modulators of the luteinizing hormone/choriogonadotropin and thyroid stimulating hormone receptors: structure-activity relationships and selective binding patterns

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Deletions in the third intracellular loop of the thyrotropin receptor. A new mechanism for constitutive activation

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Somatic mutations causing constitutive activity of the thyrotropin receptor are the major cause of hyperfunctioning thyroid adenomas: identification of additional mutations activating both the cyclic adenosine 3',5'-monophosphate and inositol phosph

21 January 2018

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Novel thyrotropin receptor germline mutation (Ile568Val) in a Saxonian family with hereditary nonautoimmune hyperthyroidism

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Functional characteristics of three new germline mutations of the thyrotropin receptor gene causing autosomal dominant toxic thyroid hyperplasia

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Crystal structure of rhodopsin: A G protein-coupled receptor

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21 January 2018

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Rapid accumulation of inositol trisphosphate reveals that agonists hydrolyse polyphosphoinositides instead of phosphatidylinositol

21 January 2018

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Activation of the beta 2-adrenergic receptor involves disruption of an ionic lock between the cytoplasmic ends of transmembrane segments 3 and 6.

21 January 2018

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A low molecular weight agonist signals by binding to the transmembrane domain of thyroid-stimulating hormone receptor (TSHR) and luteinizing hormone/chorionic gonadotropin receptor (LHCGR).

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Epitope mapping of CCR5 reveals multiple conformational states and distinct but overlapping structures involved in chemokine and coreceptor function

21 January 2018

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Role of cysteine residues in the extracellular domain and exoplasmic loops of the transmembrane domain of the TSH receptor: effect of mutation to serine on TSH receptor activity and response to thyroid stimulating autoantibodies

21 January 2018

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Delayed puberty and primary amenorrhea associated with a novel mutation of the human follicle-stimulating hormone receptor: clinical, histological, and molecular studies

21 January 2018

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H3 relaxin is a specific ligand for LGR7 and activates the receptor by interacting with both the ectodomain and the exoloop 2

21 January 2018

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Identification of the extracellular loop 2 as the point of interaction between the N terminus of the chemokine MIP-1alpha and its CCR1 receptor

21 January 2018

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Agonist versus antagonist action of ATP at the P2Y4 receptor is determined by the second extracellular loop

21 January 2018

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Ala/Thr(201) in extracellular loop 2 and Leu/Phe(290) in transmembrane domain 6 of type 1 frog gonadotropin-releasing hormone receptor confer differential ligand sensitivity and signal transduction

21 January 2018

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Mutations of the second extracellular loop of the human lutropin receptor emphasize the importance of receptor activation and de-emphasize the importance of receptor phosphorylation in agonist-induced internalization

21 January 2018

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A hydrophobic cluster in the center of the third extracellular loop is important for thyrotropin receptor signaling

21 January 2018

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A free carboxylate oxygen in the side chain of position 674 in transmembrane domain 7 is necessary for TSH receptor activation

21 January 2018

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Structural determinants for g protein activation and selectivity in the second intracellular loop of the thyrotropin receptor

21 January 2018

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An activation switch in the rhodopsin family of G protein-coupled receptors: the thyrotropin receptor

21 January 2018

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21 January 2018

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Pharmacochaperones post-translationally enhance cell surface expression by increasing conformational stability of wild-type and mutant vasopressin V2 receptors

21 January 2018

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Architecture of P2Y nucleotide receptors: structural comparison based on sequence analysis, mutagenesis, and homology modeling.

21 January 2018

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Structural and functional characterization of the human CCR5 receptor in complex with HIV gp120 envelope glycoprotein and CD4 receptor by molecular modeling studies

21 January 2018

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Molecular mechanism of 7TM receptor activation--a global toggle switch model

21 January 2018

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A molecular dissection of the glycoprotein hormone receptors.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M606176200

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1 November 2017

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