(Q42509354)

1 November 2017

title

Phosphatidylinositol-3 kinase activity in B cells is negatively regulated by Lyn tyrosine kinase (English)

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1 November 2017

4

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1 November 2017

Yuekang Xu

1

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1 November 2017

Nicholas D Huntington

2

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1 November 2017

Kenneth W Harder

3

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1 November 2017

Margaret L Hibbs

5

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1 November 2017

David M Tarlinton

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1 November 2017

publication date

10 July 2012

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Immunology & Cell Biology

1 November 2017

published in

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1 November 2017

volume

90

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1 November 2017

issue

9

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1 November 2017

page(s)

903-911

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Syk activation by the Src-family tyrosine kinase in the B cell receptor signaling

1 November 2017

cites work

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https://api.crossref.org/works/10.1038%2FICB.2012.31

Syk protein-tyrosine kinase is regulated by tyrosine-phosphorylated Ig alpha/Ig beta immunoreceptor tyrosine activation motif binding and autophosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.31

Conformational changes induced in the protein tyrosine kinase p72syk by tyrosine phosphorylation or by binding of phosphorylated immunoreceptor tyrosine-based activation motif peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.31

Altered antigen receptor signaling and impaired Fas-mediated apoptosis of B cells in Lyn-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.31

Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.31

Defective negative regulation of antigen receptor signaling in Lyn-deficient B lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.31

Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.31

Syk and Bruton's tyrosine kinase are required for B cell antigen receptor-mediated activation of the kinase Akt.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.31

A role in B cell activation for CD22 and the protein tyrosine phosphatase SHP

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.31

Role of phosphoinositide 3-kinase in activation of ras and mitogen-activated protein kinase by epidermal growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.31

Convergence of signaling pathways on the activation of ERK in B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.31

Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.31

The tyrosine kinases Syk and Lyn exert opposing effects on the activation of protein kinase Akt/PKB in B lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.31

Complementary roles for CD19 and Bruton's tyrosine kinase in B lymphocyte signal transduction

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2012.31

Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2012.31

Temporal differences in the activation of three classes of non-transmembrane protein tyrosine kinases following B-cell antigen receptor surface engagement

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2012.31

Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.31

BLNK required for coupling Syk to PLC gamma 2 and Rac1-JNK in B cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2012.31

Functional analysis of Csk in signal transduction through the B-cell antigen receptor.

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2012.31

Activation-induced endocytosis of the raft-associated transmembrane adaptor protein LAB/NTAL in B lymphocytes: evidence for a role in internalization of the B cell receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.31

Constitutive exclusion of Csk from Hck-positive membrane microdomains permits Src kinase-dependent proliferation of Theileria-transformed B lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.31

The p85 regulatory subunit controls sequential activation of phosphoinositide 3-kinase by Tyr kinases and Ras.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.31

The SH2 domain containing tyrosine phosphatase-1 down-regulates activation of Lyn and Lyn-induced tyrosine phosphorylation of the CD19 receptor in B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.31

Gain- and loss-of-function Lyn mutant mice define a critical inhibitory role for Lyn in the myeloid lineage

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2012.31

The activation and subsequent regulatory roles of Lyn and CD19 after B cell receptor ligation are independent

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2012.31

Sustained activation of Lyn tyrosine kinase in vivo leads to autoimmunity

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2012.31

CD19 regulates Src family protein tyrosine kinase activation in B lymphocytes through processive amplification

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2012.31

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2012.31

Regulation of signaling in B cells through the phosphorylation of Syk on linker region tyrosines. A mechanism for negative signaling by the Lyn tyrosine kinase

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2012.31

B cell receptor-mediated Syk-independent activation of phosphatidylinositol 3-kinase, Ras, and mitogen-activated protein kinase pathways

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2012.31

Essential role of Src-family protein tyrosine kinases in NF-kappaB activation during B cell development

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2012.31

Negative regulation of immunoglobulin E-dependent allergic responses by Lyn kinase

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2012.31

Activation of phosphatidylinositol-3' kinase by Src-family kinase SH3 binding to the p85 subunit

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2012.31

Inhibition of the B cell by CD22: a requirement for Lyn

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2012.31

Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2012.31

7 January 2021

Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient mice

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https://api.crossref.org/works/10.1038%2FICB.2012.31

7 January 2021

Co-ligation of the antigen and Fc receptors gives rise to the selective modulation of intracellular signaling in B cells. Regulation of the association of phosphatidylinositol 3-kinase and inositol 5'-phosphatase with the antigen receptor complex

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https://api.crossref.org/works/10.1038%2FICB.2012.31

7 January 2021

Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation

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https://api.crossref.org/works/10.1038%2FICB.2012.31

7 January 2021

Inhibition of phosphatidylinositol 3-kinase blocks T cell antigen receptor/CD3-induced activation of the mitogen-activated kinase Erk2

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https://api.crossref.org/works/10.1038%2FICB.2012.31

7 January 2021

B Cell Growth Is Controlled by Phosphatidylinosotol 3-Kinase-Dependent Induction of Rel/NF-κB Regulated c-myc Transcription

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https://api.crossref.org/works/10.1038%2FICB.2012.31

7 January 2021

beta1-Integrins induce phosphorylation of Akt on serine 473 independently of focal adhesion kinase and Src family kinases

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https://api.crossref.org/works/10.1038%2FICB.2012.31

7 January 2021

Structural basis for selective inhibition of Src family kinases by PP1

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https://api.crossref.org/works/10.1038%2FICB.2012.31

7 January 2021

SHP-1 regulates Lck-induced phosphatidylinositol 3-kinase phosphorylation and activity

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https://api.crossref.org/works/10.1038%2FICB.2012.31

7 January 2021

Identifiers

DOI

10.1038/ICB.2012.31

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1 November 2017

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