(Q42512974)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22993295%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

title

Reversal of disease-related pathologies in the fragile X mouse model by selective activation of GABAB receptors with arbaclofen (English)

1 reference

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13 February 2020

0 references

13

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13 February 2020

author name string

Christina Henderson

1

1 reference

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13 February 2020

Lasani Wijetunge

2

1 reference

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13 February 2020

Mika Nakamoto Kinoshita

3

1 reference

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13 February 2020

Matthew Shumway

4

1 reference

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13 February 2020

Rebecca S Hammond

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22993295%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

Friso R Postma

6

1 reference

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13 February 2020

Christopher Brynczka

7

1 reference

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13 February 2020

Roger Rush

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22993295%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

Alexia Thomas

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22993295%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

Richard Paylor

10

1 reference

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13 February 2020

Stephen T Warren

11

1 reference

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13 February 2020

Peter W Vanderklish

12

1 reference

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13 February 2020

Randall L Carpenter

14

1 reference

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13 February 2020

Mark F Bear

15

1 reference

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13 February 2020

Aileen M Healy

16

1 reference

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13 February 2020

language of work or name

English

0 references

publication date

1 September 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22993295%20AND%20SRC:MED&resulttype=core&format=json

Science Translational Medicine

13 February 2020

published in

1 reference

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13 February 2020

volume

4

1 reference

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13 February 2020

issue

152

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13 February 2020

page(s)

152ra128

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13 February 2020

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

Advances in the treatment of fragile X syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

The pathophysiology of fragile x syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

Fragile X syndrome: assessment and treatment implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

Social approach and autistic behavior in children with fragile X syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

Fragile X and autism: Intertwined at the molecular level leading to targeted treatments

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

Fragile X mental retardation protein FMRP binds mRNAs in the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

Synaptic regulation of protein synthesis and the fragile X protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

Fragile X mental retardation protein is translated near synapses in response to neurotransmitter activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

The mGluR theory of fragile X mental retardation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

Altered synaptic plasticity in a mouse model of fragile X mental retardation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

Metabotropic glutamate receptors trigger postsynaptic protein synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

Fragile X mental retardation protein is necessary for neurotransmitter-activated protein translation at synapses

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

Loss of the fragile X mental retardation protein decouples metabotropic glutamate receptor dependent priming of long-term potentiation from protein synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

Mutations causing syndromic autism define an axis of synaptic pathophysiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

Prolonged epileptiform discharges induced by altered group I metabotropic glutamate receptor-mediated synaptic responses in hippocampal slices of a fragile X mouse model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

Metabotropic receptor-dependent long-term depression persists in the absence of protein synthesis in the mouse model of fragile X syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

Role for metabotropic glutamate receptor 5 (mGluR5) in the pathogenesis of fragile X syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

Toward Fulfilling the Promise of Molecular Medicine in Fragile X Syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

Local RNA translation at the synapse and in disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

Fragile X mental retardation protein deficiency leads to excessive mGluR5-dependent internalization of AMPA receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

Hypersensitivity to mGluR5 and ERK1/2 leads to excessive protein synthesis in the hippocampus of a mouse model of fragile X syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

Early developmental alterations in GABAergic protein expression in fragile X knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

Decreased expression of the GABAA receptor in fragile X syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

Decreased GABA(A) receptor expression in the seizure-prone fragile X mouse.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

Major defects in neocortical GABAergic inhibitory circuits in mice lacking the fragile X mental retardation protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

Imbalance of neocortical excitation and inhibition and altered UP states reflect network hyperexcitability in the mouse model of fragile X syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

Defective GABAergic neurotransmission and pharmacological rescue of neuronal hyperexcitability in the amygdala in a mouse model of fragile X syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

Aberrant brain activation during gaze processing in boys with fragile X syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

Early continuous inhibition of group 1 mGlu signaling partially rescues dendritic spine abnormalities in the Fmr1 knockout mouse model for fragile X syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

The fragile X mental retardation protein and group I metabotropic glutamate receptors regulate levels of mRNA granules in brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

Altered mRNA transport, docking, and protein translation in neurons lacking fragile X mental retardation protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

Postadolescent changes in regional cerebral protein synthesis: an in vivo study in the FMR1 null mouse.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

A phenotypic and molecular characterization of the fmr1-tm1Cgr fragile X mouse.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

Fmrp is required for the establishment of the startle response during the critical period of auditory development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

Subchronic administration and combination metabotropic glutamate and GABAB receptor drug therapy in fragile X syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

Behavioral phenotype of fragile X syndrome: DSM-III-R autistic behavior in male children

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

Marble burying reflects a repetitive and perseverative behavior more than novelty-induced anxiety

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

Simple pharmacological test battery to assess efficacy and side effect profile of centrally acting muscle relaxant drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

Behavioral phenotyping of mice in pharmacological and toxicological research

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

Biochemical evidence for the association of fragile X mental retardation protein with brain polyribosomal ribonucleoparticles

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

Enriched environment promotes behavioral and morphological recovery in a mouse model for the fragile X syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

Dendritic spine structural anomalies in fragile-X mental retardation syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

Abnormal dendritic spine characteristics in the temporal and visual cortices of patients with fragile-X syndrome: a quantitative examination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

Analysis of neocortex in three males with the fragile X syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

Adult fragile X syndrome. Clinico-neuropathologic findings

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

The Fra(X) syndrome: neurological, electrophysiological, and neuropathological abnormalities

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

Which comes first in fragile X syndrome, dendritic spine dysgenesis or defects in circuit plasticity?

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

The state of synapses in fragile X syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

Chronic pharmacological mGlu5 inhibition corrects fragile X in adult mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

Structural plasticity of dendritic spines

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

Spine distribution along the apical dendrites of the pyramidal neurons in Down's syndrome. A quantitative Golgi study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

Reduced dendritic spine density on cerebral cortical pyramidal neurons in schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

Sequence of abnormal dendritic spine development in primary somatosensory cortex of a mouse model of the fragile X mental retardation syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

Developmental regulation of spine and filopodial motility in primary visual cortex: reduced effects of activity and sensory deprivation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

Synaptogenesis in the developing mouse visual cortex

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

Delayed stabilization of dendritic spines in fragile X mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

Critical period plasticity is disrupted in the barrel cortex of FMR1 knockout mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

Altered maturation of the primary somatosensory cortex in a mouse model of fragile X syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

Dendritic spine instability and insensitivity to modulation by sensory experience in a mouse model of fragile X syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

No change in the age of diagnosis for fragile x syndrome: findings from a national parent survey

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

The pathophysiology of fragile X (and what it teaches us about synapses)

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

Minocycline promotes dendritic spine maturation and improves behavioural performance in the fragile X mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

The Drosophila easily shocked gene: a mutation in a phospholipid synthetic pathway causes seizure, neuronal failure, and paralysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

Dissociation of social and nonsocial anxiety in a mouse model of fragile X syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

Behavioral and neuroanatomical characterization of the Fmr1 knockout mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

Alterations in the auditory startle response in Fmr1 targeted mutant mouse models of fragile X syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

Social behavior in Fmr1 knockout mice carrying a human FMR1 transgene

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

Genetic reduction of group 1 metabotropic glutamate receptors alters select behaviors in a mouse model for fragile X syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

Group I metabotropic glutamate receptor antagonists alter select behaviors in a mouse model for fragile X syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

Modulation of behavioral phenotypes by a muscarinic M1 antagonist in a mouse model of fragile X syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

The modulation of fragile X behaviors by the muscarinic M4 antagonist, tropicamide

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

Genetic reduction of muscarinic M4 receptor modulates analgesic response and acoustic startle response in a mouse model of fragile X syndrome (FXS).

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

Cognitive dysfunction and prefrontal synaptic abnormalities in a mouse model of fragile X syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

Epigenetic modification of the FMR1 gene in fragile X syndrome is associated with differential response to the mGluR5 antagonist AFQ056.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

Differential trafficking of AMPA and NMDA receptors during long-term potentiation in awake adult animals.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

Excess phosphoinositide 3-kinase subunit synthesis and activity as a novel therapeutic target in fragile X syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

Culturing hippocampal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

mGluR5 regulates glutamate-dependent development of the mouse somatosensory cortex

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004218

10.1126/SCITRANSLMED.3004218

21 January 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22993295%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

1 reference