(Q42523817)

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The type 1 interleukin-1 receptor is essential for the efficient activation of microglia and the induction of multiple proinflammatory mediators in response to brain injury.

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11 November 2019

The type 1 interleukin-1 receptor is essential for the efficient activation of microglia and the induction of multiple proinflammatory mediators in response to brain injury (English)

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11 November 2019

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Steven T. DeKosky

5

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11 November 2019

author name string

Anirban Basu

1

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11 November 2019

J Kyle Krady

2

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11 November 2019

Mark O'Malley

3

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11 November 2019

Scott D Styren

4

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11 November 2019

Steven W Levison

6

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11 November 2019

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1 July 2002

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11 November 2019

Journal of Neuroscience

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11 November 2019

22

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11 November 2019

6071-6082

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11 November 2019

14

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11 November 2019

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6757935/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Strongly compromised inflammatory response to brain injury in interleukin-6-deficient mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12122068

12 December 2020

based on heuristic

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Leptin actions on food intake and body temperature are mediated by IL-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/12122068

12 December 2020

based on heuristic

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Potentiation of excitotoxicity in transgenic mice overexpressing neuronal cyclooxygenase-2

1 reference

https://pubmed.ncbi.nlm.nih.gov/12122068

12 December 2020

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In vivo expression of cyclooxygenase-2 in rat brain following intraparenchymal injection of bacterial endotoxin and inflammatory cytokines

1 reference

https://pubmed.ncbi.nlm.nih.gov/12122068

12 December 2020

based on heuristic

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Quantitative changes in interleukin proteins following focal stroke in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/12122068

12 December 2020

based on heuristic

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Inflammation and Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12122068

12 December 2020

based on heuristic

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Comparative evaluation of cytokine profiles and reactive gliosis supports a critical role for interleukin-6 in neuron-glia signaling during regeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/12122068

12 December 2020

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The pervasiveness of interleukin-1 in alzheimer pathogenesis: a role for specific polymorphisms in disease risk

1 reference

https://pubmed.ncbi.nlm.nih.gov/12122068

12 December 2020

based on heuristic

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Interleukin-1 receptor type I gene-deficient mice are less susceptible to Staphylococcus epidermidis biomaterial-associated infection than are wild-type mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12122068

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin 1 in the brain: biology, pathology and therapeutic target

1 reference

https://pubmed.ncbi.nlm.nih.gov/12122068

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of IL-1alpha and IL-1beta in ischemic brain damage.

1 reference

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12 December 2020

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Ciliary neurotrophic factor activates spinal cord astrocytes, stimulating their production and release of fibroblast growth factor-2, to increase motor neuron survival

1 reference

https://pubmed.ncbi.nlm.nih.gov/12122068

12 December 2020

based on heuristic

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Production of hemolymphopoietic cytokines (IL-6, IL-8, colony-stimulating factors) by normal human astrocytes in response to IL-1 beta and tumor necrosis factor-alpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/12122068

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-1 receptor antagonist inhibits ischaemic and excitotoxic neuronal damage in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/12122068

12 December 2020

based on heuristic

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Evaluation of IL-2, sIL2R, IL-6, TNF-alpha, and IL-1 beta levels in serum and CSF of patients with optic neuritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12122068

12 December 2020

based on heuristic

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Basic FGF in astroglial, microglial, and neuronal cultures: characterization of binding sites and modulation of release by lymphokines and trophic factors

1 reference

https://pubmed.ncbi.nlm.nih.gov/12122068

12 December 2020

based on heuristic

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Cytokine regulation of interleukin-6 gene expression in astrocytes involves activation of an NF-κ B-like nuclear protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/12122068

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of interleukin-1 beta mRNA in rat brain after transient forebrain ischemia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12122068

12 December 2020

based on heuristic

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Transforming growth factor-beta 1 (TGF-β1) expression and regulation in rat cortical astrocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/12122068

12 December 2020

based on heuristic

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Experimental autoimmune encephalomyelitis is exacerbated by IL-1 alpha and suppressed by soluble IL-1 receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/12122068

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism of nerve growth factor mRNA regulation by interleukin-1 and basic fibroblast growth factor in primary cultures of rat astrocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/12122068

12 December 2020

based on heuristic

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Interleukin-1 beta and tumor necrosis factor-alpha synergistically stimulate nerve growth factor (NGF) release from cultured rat astrocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/12122068

12 December 2020

based on heuristic

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Tumor necrosis factor-alpha production by astrocytes. Induction by lipopolysaccharide, IFN-gamma, and IL-1 beta

1 reference

https://pubmed.ncbi.nlm.nih.gov/12122068

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of beta-nerve growth factor expression by inflammatory mediators in hippocampal cultures.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12122068

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regional and cellular codistribution of interleukin 1 beta and nerve growth factor mRNA in the adult rat brain: possible relationship to the regulation of nerve growth factor synthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12122068

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-1 injected into mammalian brain stimulates astrogliosis and neovascularization

1 reference

https://pubmed.ncbi.nlm.nih.gov/12122068

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12122068

12 December 2020

based on heuristic

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Immunoregulatory molecules and IL 2 receptors identified in multiple sclerosis brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/12122068

12 December 2020

based on heuristic

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Use of carbon labeling to demonstrate the role of blood monocytes as precursors of the 'ameboid cells' present in the corpus callosum of postnatal rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12122068

12 December 2020

based on heuristic

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Microglial interleukin-1 alpha expression in brain regions in Alzheimer's disease: correlation with neuritic plaque distribution.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12122068

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signal transduction pathways mediating astrocyte IL-6 induction by IL-1 beta and tumor necrosis factor-alpha.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12122068

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6

1 reference

https://pubmed.ncbi.nlm.nih.gov/12122068

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-1 as a pathogenetic mediator of ischemic brain damage in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/12122068

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Upregulation of nerve growth factor following cortical trauma.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12122068

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Demonstration of poly-N-acetyl lactosamine residues in ameboid and ramified microglial cells in rat brain by tomato lectin binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/12122068

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The immortalized astroglial cell line RC7 is a new model system for the study of nerve growth factor (NGF) regulation: stimulation by interleukin-1 beta and transforming growth factor-beta 1 is additive and affected differently by dibutyryl cyclic A

1 reference

https://pubmed.ncbi.nlm.nih.gov/12122068

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Postischemic administration of an anti-Mac-1 antibody reduces ischemic cell damage after transient middle cerebral artery occlusion in rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12122068

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Significance of the inflammatory response in brain ischemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/12122068

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroprotective effects of human recombinant interleukin-1 receptor antagonist in focal cerebral ischaemia in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12122068

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acute exposure to CNTF in vivo induces multiple components of reactive gliosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12122068

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of nerve growth factor mRNA by interleukin-1 in rat hippocampal astrocytes is mediated by NFkappaB.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12122068

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Progressive decline in avoidance learning paralleled by inflammatory neurodegeneration in transgenic mice expressing interleukin 6 in the brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/12122068

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of interleukin 1beta converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage

1 reference

https://pubmed.ncbi.nlm.nih.gov/12122068

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impaired neuroglial activation in interleukin-6 deficient mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12122068

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of a dominant negative mutant of interleukin-1 beta converting enzyme in transgenic mice prevents neuronal cell death induced by trophic factor withdrawal and ischemic brain injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/12122068

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human leukocyte antigens and cytokine expression in cerebral inflammatory demyelinative lesions of X-linked adrenoleukodystrophy and multiple sclerosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12122068

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phenotypic and functional characterization of mice that lack the type I receptor for IL-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/12122068

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced fertility and postischaemic brain injury in mice deficient in cytosolic phospholipase A2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12122068

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced ischemic brain injury in interleukin-1 beta converting enzyme-deficient mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12122068

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exacerbation of ischemic brain damage by localized striatal injection of interleukin-1beta in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12122068

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclooxygenase-2 expression is increased in frontal cortex of Alzheimer's disease brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12122068

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.22-14-06071.2002

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12122068%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12122068%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12122068%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

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