(Q42538398)

1 November 2017

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title

Analogs of staurosporine: potential anticancer drugs? (English)

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1 November 2017

A Gescher

1

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1 November 2017

publication date

1 November 1998

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1 November 2017

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1 November 2017

volume

31

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1 November 2017

issue

5

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1 November 2017

page(s)

721-728

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Enhancement of antitumor activity of mitomycin C in vitro and in vivo by UCN-01, a selective inhibitor of protein kinase C

1 November 2017

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7 January 2021

The protein kinase C inhibitors Ro 318220 and GF 109203X are equally potent inhibitors of MAPKAP kinase-1beta (Rsk-2) and p70 S6 kinase.

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7 January 2021

Signal transduction for proliferation of glioma cells in vitro occurs predominantly through a protein kinase C-mediated pathway.

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7 January 2021

Chemosensitization of cancer cells by the staurosporine derivative CGP 41251 in association with decreased P-glycoprotein phosphorylation

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7 January 2021

Differential inhibition of cytosolic and membrane-derived protein kinase C activity by staurosporine and other kinase inhibitors

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7 January 2021

Comparison of staurosporine and four analogues: their effects on growth, rhodamine 123 retention and binding to P-glycoprotein in multidrug-resistant MCF-7/Adr cells

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7 January 2021

Co-ordinate loss of protein kinase C and multidrug resistance gene expression in revertant MCF-7/Adr breast carcinoma cells

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7 January 2021

Comparison of ability of protein kinase C inhibitors to arrest cell growth and to alter cellular protein kinase C localisation

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7 January 2021

Differential effects of staurosporine analogues on cell cycle, growth and viability in A549 cells

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7 January 2021

Characterisation of novel human lung carcinoma cell lines selected for resistance to anti-neoplastic analogues of staurosporine

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7 January 2021

Phorbol esters induce multidrug resistance in human breast cancer cells

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7 January 2021

Induction of apoptosis in chronic lymphocytic leukemia cells and its prevention by phorbol ester

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7 January 2021

Activation of protein kinase C subtypes alpha, gamma, delta, epsilon, zeta, and eta by tumor-promoting and nontumor-promoting agents

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7 January 2021

Characterization of phosphorylation-defective mutants of human P-glycoprotein expressed in mammalian cells

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7 January 2021

Protein kinase C-mediated phosphorylation does not regulate drug transport by the human multidrug resistance P-glycoprotein

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7 January 2021

Disposition in mice of 7-hydroxystaurosporine, a protein kinase inhibitor with antitumor activity

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7 January 2021

Antitumor effect of CGP41251, a new selective protein kinase C inhibitor, on human non-small cell lung cancer cells

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7 January 2021

Amelioration of vascular dysfunctions in diabetic rats by an oral PKC beta inhibitor

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7 January 2021

Protein kinase C isozymes and substrates

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7 January 2021

UCN-01, 7-hydroxyl-staurosporine, inhibits kinase activity of cyclin-dependent kinases and reduces the phosphorylation of the retinoblastoma susceptibility gene product in A549 human lung cancer cell line

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7 January 2021

How does p21ras transform cells?

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7 January 2021

A derivative of staurosporine (CGP 41 251) shows selectivity for protein kinase C inhibition and in vitro anti-proliferative as well as in vivo anti-tumor activity

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7 January 2021

UCN-01, an anti-tumor drug, is a selective inhibitor of the conventional PKC subfamily

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7 January 2021

Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C

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7 January 2021

Animal cell cycles and their control

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7 January 2021

A new alkaloid AM-2282 OF Streptomyces origin. Taxonomy, fermentation, isolation and preliminary characterization

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7 January 2021

Blocking of glioma proliferation in vitro and in vivo and potentiating the effects of BCNU and cisplatin: UCN-01, a selective protein kinase C inhibitor.

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7 January 2021

Anticancer drugs acting against signaling pathways

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7 January 2021

Protein kinase inhibitor-induced alterations of drug uptake, cell cycle and surface antigen expression in human multidrug-resistant (Pgp and MRP) promyelocytic leukemia HL-60 cells

1 reference

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7 January 2021

7-Hydroxystaurosporine (UCN-01) induces apoptosis in human colon carcinoma and leukemia cells independently of p53

1 reference

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7 January 2021

Differing effects of staurosporine and UCN-01 on RB protein phosphorylation and expression of lung cancer cell lines

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7 January 2021

UCN-01, a selective inhibitor of protein kinase C from Streptomyces.

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7 January 2021

UCN-01 and UCN-02, new selective inhibitors of protein kinase C. I. Screening, producing organism and fermentation

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2898%2900069-X

7 January 2021

UCN-01 and UCN-02, new selective inhibitors of protein kinase C. II. Purification, physico-chemical properties, structural determination and biological activities

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7 January 2021

Potent and specific inhibitors of protein kinase C of microbial origin

1 reference

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7 January 2021

Structures of staurosporine bound to CDK2 and cAPK--new tools for structure-based design of protein kinase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2898%2900069-X

7 January 2021

The protein kinase C inhibitor CGP 41251, a staurosporine derivative with antitumor activity, reverses multidrug resistance.

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2898%2900069-X

7 January 2021

UCN-01: a potent abrogator of G2 checkpoint function in cancer cells with disrupted p53.

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2898%2900069-X

7 January 2021

The retinoblastoma protein and cell cycle control

1 reference

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7 January 2021

10.1016/S0306-3623(98)00069-X

Identifiers

DOI

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1 November 2017

1 reference