(Q42593680)

3 November 2017

Human liver microsomal metabolism of (+)-discodermolide (English)

1 reference

3 November 2017

Discodermia dissoluta

1 reference

1 reference

Yun Fan

1

1 reference

3 November 2017

Emanuel M Schreiber

series ordinal

2

1 reference

3 November 2017

Billy W Day

series ordinal

3

1 reference

3 November 2017

23 September 2009

1 reference

Crossref

full work available at URL

16 September 2022

https://europepmc.org/articles/pmc2768424?pdf=render

1 reference

19 March 2024

https://api.unpaywall.org/v2/10.1021/np900245k?email=unpaywall_01@example.com

published in

Journal of Natural Products

1 reference

3 November 2017

72

1 reference

3 November 2017

10

1 reference

3 November 2017

1748-1754

1 reference

https://api.unpaywall.org/v2/10.1021/np900245k?email=unpaywall_01@example.com

3 November 2017

1 reference

19 March 2024

access restriction status

open access

1 reference

based on heuristic

inferred from online access status

cites work

The bound conformation of microtubule-stabilizing agents: NMR insights into the bioactive 3D structure of discodermolide and dictyostatin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768424

The structure activity relationship of discodermolide analogues

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768424

Potentiation of taxol efficacy and by discodermolide in ovarian carcinoma xenograft-bearing mice

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768424

Toward understanding how the lactone moiety of discodermolide affects activity.

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768424

Mutations in beta-tubulin map to domains involved in regulation of microtubule stability in epothilone-resistant cell lines.

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768424

The microtubule-stabilizing agent discodermolide competitively inhibits the binding of paclitaxel (Taxol) to tubulin polymers, enhances tubulin nucleation reactions more potently than paclitaxel, and inhibits the growth of paclitaxel-resistant cells

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768424

(+)-Discodermolide binds to microtubules in stoichiometric ratio to tubulin dimers, blocks taxol binding and results in mitotic arrest

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768424

Discodermolide, a cytotoxic marine agent that stabilizes microtubules more potently than taxol

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768424

Immunosuppression by discodermolide.

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768424

Discodermolide--a new, marine-derived immunosuppressive compound. II. In vivo studies

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768424

Discodermolide--a new, marine-derived immunosuppressive compound. I. In vitro studies

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768424

Microtubule interactions with chemically diverse stabilizing agents: thermodynamics of binding to the paclitaxel site predicts cytotoxicity

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768424

Semisynthetic analogues of the microtubule-stabilizing agent discodermolide: preparation and biological activity

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768424

Solution structure of (+)-discodermolide

16 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19775091

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Design, synthesis, and biological evaluation of simplified analogues of (+)-discodermolide. Additional insights on the importance of the diene, the C7 hydroxyl, and the lactone

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19775091

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/NP900245K

1 reference

3 November 2017

1 reference

3 November 2017

PubMed publication ID

19775091

1 reference