(Q42604824)

English

A human anti-insulin IgG autoantibody apparently arises through clonal selection from an insulin-specific "germ-line" natural antibody template. Analysis by V gene segment reassortment and site-directed mutagenesis

scientific article published on January 1995

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scholarly article

1 reference

Europe PubMed Central

3 November 2017

A human anti-insulin IgG autoantibody apparently arises through clonal selection from an insulin-specific "germ-line" natural antibody template. Analysis by V gene segment reassortment and site-directed mutagenesis (English)

1 reference

Europe PubMed Central

3 November 2017

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

author name string

Y Ichiyoshi

1

1 reference

Europe PubMed Central

3 November 2017

M Zhou

2

1 reference

Europe PubMed Central

3 November 2017

P Casali

3

1 reference

Europe PubMed Central

3 November 2017

language of work or name

0 references

publication date

1 January 1995

1 reference

Europe PubMed Central

3 November 2017

Journal of Immunology

1 reference

Europe PubMed Central

3 November 2017

154

1 reference

Europe PubMed Central

3 November 2017

226-238

1 reference

Europe PubMed Central

3 November 2017

1

1 reference

Europe PubMed Central

3 November 2017

Naturally occurring antibodies devoid of light chains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4626874

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Residues that mediate DNA binding of autoimmune antibodies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4626874

27 May 2018

V region diversity in human anti-insulin antibodies. Preferential use of a VHIII gene subset

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4626874

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Lack of promiscuity in autoantigen-specific H and L chain combinations as revealed by human H and L chain "roulette".

1 reference

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27 May 2018

Structural analysis of the VH-D-JH segments of human polyreactive IgG mAb. Evidence for somatic selection.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4626874

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Structure of the VH and VL segments of polyreactive and monoreactive human natural antibodies to HIV-1 and Escherichia coli beta-galactosidase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4626874

27 May 2018

VH and V kappa segment structure of anti-insulin IgG autoantibodies in patients with insulin-dependent diabetes mellitus. Evidence for somatic selection.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4626874

27 May 2018

Structure of the VH and VL segments of monoreactive and polyreactive IgA autoantibodies to DNA in patients with systemic lupus erythematosus

1 reference

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27 May 2018

Analysis of the structural correlates for antibody polyreactivity by multiple reassortments of chimeric human immunoglobulin heavy and light chain V segments

1 reference

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The CDR1 sequences of a major proportion of human germline Ig VH genes are inherently susceptible to amino acid replacement

1 reference

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Human rheumatoid B-1a (CD5+ B) cells make somatically hypermutated high affinity IgM rheumatoid factors

1 reference

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27 May 2018

Organization and evolution of immunoglobulin VH gene subgroups

1 reference

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27 May 2018

Immunoglobulin genes of different subgroups are interdigitated within the VK locus

1 reference

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Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin

1 reference

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Recovery of antibody activity on reoxidation of completely reduced polyalanyl heavy chain and its Fd fragment derived from anti-2,4-dinitrophenyl antibody

1 reference

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The Three-Dimensional Structure of a Phosphorylcholine-Binding Mouse Immunoglobulin Fab and the Nature of the Antigen Binding Site

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4626874

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Somatically mutated forms of a major anti-p-azophenylarsonate antibody variable region with drastically reduced affinity for p-azophenylarsonate. By-products of an antigen-driven immune response?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4626874

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Structure and function of anti-DNA autoantibodies derived from a single autoimmune mouse

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4626874

27 May 2018

Mutation drift and repertoire shift in the maturation of the immune response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4626874

27 May 2018

A 16/6 idiotype-positive anti-DNA antibody is encoded by a conserved VH gene with no somatic mutation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4626874

27 May 2018

Stepwise intraclonal maturation of antibody affinity through somatic hypermutation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4626874

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Antibody engineering for the analysis of affinity maturation of an anti-hapten response.

1 reference

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27 May 2018

Isolation and characterization of human VkIII germ-line genes. Implications for the molecular basis of human VkIII light chain diversity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4626874

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High-frequency expression of a conserved kappa light-chain variable-region gene in chronic lymphocytic leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4626874

27 May 2018

V kappa and J kappa gene segments of A/J Ars-A antibodies: somatic recombination generates the essential arginine at the junction of the variable and joining regions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4626874

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Probing the normal and autoimmune B cell repertoire with Epstein-Barr virus. Frequency of B cells producing monoreactive high affinity autoantibodies in patients with Hashimoto's disease and systemic lupus erythematosus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4626874

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Structure of an antibody-antigen complex: crystal structure of the HyHEL-10 Fab-lysozyme complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4626874

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Binding activities of a repertoire of single immunoglobulin variable domains secreted from Escherichia coli

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4626874

27 May 2018

Stable expression and somatic hypermutation of antibody V regions in B-cell developmental pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4626874

27 May 2018

A natural autoantibody is encoded by germline heavy and lambda light chain variable region genes without somatic mutation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4626874

27 May 2018

Two murine natural polyreactive autoantibodies are encoded by nonmutated germ-line genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4626874

27 May 2018

Nucleotide sequences of eight human natural autoantibody VH regions reveals apparent restricted use of VH families.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4626874

27 May 2018

Complete protein sequences of the variable regions of the cloned heavy and light chains of a human anti-cytomegalovirus antibody reveal a striking similarity to human monoclonal rheumatoid factors of the Wa idiotypic family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4626874

27 May 2018

Three-dimensional structure of an antibody-antigen complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4626874

27 May 2018

Clonal recruitment and somatic mutation in the generation of immunological memory to the hapten NP

1 reference

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Structural and functional implications of a restricted antibody response to a defined antigenic region on the influenza virus hemagglutinin.

1 reference

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27 May 2018

Structural correlates of high antibody affinity: three engineered amino acid substitutions can increase the affinity of an anti-p-azophenylarsonate antibody 200-fold

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4626874

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Crystal structures of an antibody to a peptide and its complex with peptide antigen at 2.8 A

1 reference

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The complete nucleotide sequences of the heavy chain variable regions of six monospecific rheumatoid factors derived from Epstein-Barr virus-transformed B cells isolated from the synovial tissue of patients with rheumatoid arthritis. Further evidenc

1 reference

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27 May 2018

Frequency of B cells committed to the production of antibodies to insulin in newly diagnosed patients with insulin-dependent diabetes mellitus and generation of high affinity human monoclonal IgG to insulin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4626874

27 May 2018

Clonal analysis of a human antibody response. Quantitation of precursors of antibody-producing cells and generation and characterization of monoclonal IgM, IgG, and IgA to rabies virus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4626874

27 May 2018

VH and VL gene usage by murine IgG antibodies that bind autologous insulin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4626874

27 May 2018

Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4626874

27 May 2018

Identical V region amino acid sequences and segments of sequences in antibodies of different specificities. Relative contributions of VH and VL genes, minigenes, and complementarity-determining regions to binding of antibody-combining sites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4626874

27 May 2018

Kinetic maturation of an immune response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4626874

27 May 2018

Somatic mutations in the variable regions of a human IgG anti-double-stranded DNA autoantibody suggest a role for antigen in the induction of systemic lupus erythematosus

1 reference

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27 May 2018

Ig H and L chain contributions to autoimmune specificities

1 reference

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27 May 2018

Genetic analysis of self-associating immunoglobulin G rheumatoid factors from two rheumatoid synovia implicates an antigen-driven response

1 reference

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27 May 2018

Complete sequence of the genes encoding the VH and VL regions of low- and high- affinity monoclonal lgM and lgA1 rheumatoid factors produced by CD5+ B cells from a rheumatoid arthritis patient

1 reference

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27 May 2018

Molecular characteristics of antibodies bearing an anti-DNA-associated idiotype

1 reference

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27 May 2018

A human systemic lupus erythematosus-related anti-cardiolipin/single-stranded DNA autoantibody is encoded by a somatically mutated variant of the developmentally restricted 51P1 VH gene

1 reference

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Generation and analysis of random point mutations in an antibody CDR2 sequence: many mutated antibodies lose their ability to bind antigen

1 reference

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27 May 2018

Structural repertoire of the human VH segments

1 reference

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Therapeutic Human Antibodies Derived from PCR Amplification of B‐Cell Variable Regions

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The molecular evolution of the immune response: idiotope-specific suppression indicates that B cells express germ-line-encoded V genes prior to antigenic stimulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/7995943

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetic analysis of monoclonal antibody-antigen interactions with a new biosensor based analytical system

1 reference

https://pubmed.ncbi.nlm.nih.gov/7995943

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

THE SUBUNITS OF PURIFIED RABBIT ANTIBODY

1 reference

https://pubmed.ncbi.nlm.nih.gov/7995943

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Three-dimensional structure of an antigen-antibody complex at 2.8 A resolution

1 reference

https://pubmed.ncbi.nlm.nih.gov/7995943

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Somatic mutation and the maturation of immune response to 2-phenyl oxazolone

1 reference

https://pubmed.ncbi.nlm.nih.gov/7995943

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

1 reference

Europe PubMed Central

3 November 2017

1 reference

Europe PubMed Central

3 November 2017

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