(Q42668405)

4 November 2017

Inhibition of p38 MAPK reverses hypoxia-induced pulmonary artery endothelial dysfunction (English)

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4 November 2017

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Roshan P Weerackody

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4 November 2017

David J Welsh

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2

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4 November 2017

Roger M Wadsworth

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3

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4 November 2017

Andrew J Peacock

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4

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4 November 2017

6 February 2009

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American Journal of Physiology Heart and Circulatory Physiology

4 November 2017

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4 November 2017

296

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4 November 2017

5

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4 November 2017

H1312-20

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describes a project that uses

4 November 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2685327/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Role of the adventitia in pulmonary vascular remodeling

27 May 2018

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Review: hypoxia-inducible factor-1 (HIF-1): a novel transcription factor in immune reactions.

27 May 2018

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Endothelial nitric oxide synthase: a new paradigm for gene regulation in the injured blood vessel

27 May 2018

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p38 mitogen-activated protein kinase inhibitors for the treatment of chronic cardiovascular disease

27 May 2018

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Adenoviral gene transfer of endothelial nitric-oxide synthase (eNOS) partially restores normal pulmonary arterial pressure in eNOS-deficient mice

27 May 2018

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Upregulation of nitric oxide synthase in mice with severe hypoxia-induced pulmonary hypertension

27 May 2018

1 reference

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Hypoxia-induced proliferative response of vascular adventitial fibroblasts is dependent on g protein-mediated activation of mitogen-activated protein kinases

27 May 2018

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Specificity and mechanism of action of some commonly used protein kinase inhibitors

27 May 2018

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Nitric oxide and pulmonary hypertension.

27 May 2018

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In vitro simultaneous measurements of relaxation and nitric oxide concentration in rat superior mesenteric artery.

27 May 2018

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The pulmonary circulation of homozygous or heterozygous eNOS-null mice is hyperresponsive to mild hypoxia.

27 May 2018

1 reference

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The activation state of p38 mitogen-activated protein kinase determines the efficiency of ATP competition for pyridinylimidazole inhibitor binding

27 May 2018

1 reference

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Sustained pulmonary hypertension and right ventricular hypertrophy after chronic hypoxia in mice with congenital deficiency of nitric oxide synthase 3.

27 May 2018

1 reference

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Decreased nitric oxide in the exhaled air of patients with systemic sclerosis with pulmonary hypertension

27 May 2018

1 reference

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Response of normoxic pulmonary arteries of the rat in the resting and contracted state to NO synthase blockade

27 May 2018

1 reference

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Loss of endothelium-dependent relaxant activity in the pulmonary circulation of rats exposed to chronic hypoxia

27 May 2018

1 reference

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The effect of continued hypoxia on rat pulmonary arterial circulation. An ultrastructural study

27 May 2018

1 reference

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Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats.

27 May 2018

1 reference

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Statin protects endothelial nitric oxide synthase activity in hypoxia-induced pulmonary hypertension

27 May 2018

1 reference

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Hypoxic pulmonary hypertension: role of superoxide and NADPH oxidase (gp91phox).

16 August 2018

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Modulation of PGF2alpha- and hypoxia-induced contraction of rat intrapulmonary artery by p38 MAPK inhibition: a nitric oxide-dependent mechanism

16 August 2018

1 reference

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p38 MAP kinase isoform activity and cell cycle regulators in the proliferative response of pulmonary and systemic artery fibroblasts to acute hypoxia

16 August 2018

1 reference

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C-reactive protein inhibits endothelium-dependent NO-mediated dilation in coronary arterioles by activating p38 kinase and NAD(P)H oxidase

16 August 2018

1 reference

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Induction of iNOS restricts functional activity of both eNOS and nNOS in pig cerebral artery

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2685327

Specific inhibition of p38 mitogen-activated protein kinase with FR167653 attenuates vascular proliferation in monocrotaline-induced pulmonary hypertension in rats

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2685327

Vascular endothelial dysfunction and superoxide anion production in heart failure are p38 MAP kinase-dependent

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2685327

p38 MAPK inhibitors ameliorate target organ damage in hypertension: Part 1. p38 MAPK-dependent endothelial dysfunction and hypertension

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2685327

Vasoreactions to acute hypoxia, whole lungs and isolated vessels compared: modulation by NO.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2685327

Endogenous endothelins and nitric oxide in hypoxic pulmonary vasoconstriction

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2685327

Decreased endothelial nitric-oxide synthase (eNOS) activity resulting from abnormal interaction between eNOS and its regulatory proteins in hypoxia-induced pulmonary hypertension

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2685327

Lysophosphatidylcholine induces apoptosis in human endothelial cells through a p38-mitogen-activated protein kinase-dependent mechanism

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2685327

Phytoestrogens restore nitric oxide-mediated relaxation in isolated pulmonary arteries from chronically hypoxic rats

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2685327

Accumulation of nitrotyrosine correlates with endothelial NO synthase in pulmonary resistance arteries during chronic hypoxia in the rat.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2685327

p38 MAP kinase-dependent regulation of endothelial cell permeability

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2685327

Standing up to the challenge of standing: a siphon does not support cerebral blood flow in humans

30 September 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00977.2008

5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside renders glucose output by the liver of the dog insensitive to a pharmacological increment in insulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00977.2008

Acute respiratory failure due to pneumocystis pneumonia in patients without human immunodeficiency virus infection: outcome and associated features

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00977.2008

Dysfunctional Smad Signaling Contributes to Abnormal Smooth Muscle Cell Proliferation in Familial Pulmonary Arterial Hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00977.2008

p38 MAP kinase pathway regulates angiotensin II-induced contraction of rat vascular smooth muscle

21 January 2018

1 reference

12 December 2020

Production of endogenous nitric oxide in chronic obstructive pulmonary disease and patients with cor pulmonale. Correlates with echo-Doppler assessment

1 reference

12 December 2020

Hypoxia activates jun-N-terminal kinase, extracellular signal-regulated protein kinase, and p38 kinase in pulmonary arteries

1 reference

12 December 2020

Reduced hypoxic pulmonary vascular remodeling by nitric oxide from the endothelium

1 reference

12 December 2020

Chronic hypoxia induces constitutive p38 mitogen-activated protein kinase activity that correlates with enhanced cellular proliferation in fibroblasts from rat pulmonary but not systemic arteries

1 reference

12 December 2020

Nitric oxide regulates basal systemic and pulmonary vascular resistance in healthy humans

1 reference

12 December 2020

Role of nitric oxide in the local regulation of pulmonary vascular resistance in humans

1 reference

12 December 2020

Serotonin activates the mitogen-activated protein kinase pathway in vascular smooth muscle: use of the mitogen-activated protein kinase kinase inhibitor PD098059

1 reference

12 December 2020

Exhaled nitric oxide during exercise in primary pulmonary hypertension and pulmonary fibrosis

1 reference

12 December 2020

Role of inhibition of nitric oxide production in monocrotaline-induced pulmonary hypertension

1 reference

12 December 2020

Mitogen-activated protein kinase activation: an alternate signaling pathway for sustained vascular smooth muscle contraction

1 reference

12 December 2020

Chronic hypoxia decreases nitric oxide production and endothelial nitric oxide synthase in newborn pig lungs

1 reference

12 December 2020

Biochemical reaction products of nitric oxide as quantitative markers of primary pulmonary hypertension

1 reference

12 December 2020

The role of p38 mitogen-activated protein kinase in hypoxia-induced vascular cell proliferation: an interspecies comparison

1 reference

12 December 2020

Increased oxidative stress in lambs with increased pulmonary blood flow and pulmonary hypertension: role of NADPH oxidase and endothelial NO synthase

1 reference

12 December 2020

p38 MAP kinase: essential role in hypoxia-mediated human pulmonary artery fibroblast proliferation

1 reference

12 December 2020

10.1152/AJPHEART.00977.2008

Identifiers

DOI

1 reference

4 November 2017

1 reference

4 November 2017

PubMed publication ID

19201999

1 reference