(Q42701804)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25961927%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

title

The BET bromodomain inhibitor JQ1 suppresses growth of pancreatic ductal adenocarcinoma in patient-derived xenograft models (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25961927%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

1 reference

1 reference

1 reference

invasive ductal carcinoma

1 reference

pancreatic ductal adenocarcinoma

inferred from title

1 reference

pancreatic ductal carcinoma

inferred from title

1 reference

P L Garcia

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25961927%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

A L Miller

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25961927%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

K M Kreitzburg

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25961927%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

L N Council

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25961927%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

T L Gamblin

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25961927%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

J D Christein

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25961927%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

M J Heslin

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25961927%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

J P Arnoletti

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25961927%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

J H Richardson

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25961927%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

D Chen

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25961927%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

C A Hanna

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25961927%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

S L Cramer

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25961927%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

E S Yang

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25961927%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

J Qi

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25961927%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

J E Bradner

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25961927%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

K J Yoon

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25961927%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

language of work or name

English

0 references

publication date

11 May 2015

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25961927%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25961927%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

volume

35

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25961927%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

page(s)

833-845

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25961927%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

issue

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25961927%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/onc.2015.126

7 March 2020

exact match

0 references

cites work

Cancer statistics, 2014

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.126

Preoperative/neoadjuvant therapy in pancreatic cancer: a systematic review and meta-analysis of response and resection percentages

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.126

Assessing clinical benefit in the treatment of pancreas cancer: gemcitabine compared to 5-fluorouracil

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.126

Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.126

KRAS: feeding pancreatic cancer proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.126

Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.126

Core signaling pathways in human pancreatic cancers revealed by global genomic analyses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.126

Dormant cancer cells contribute to residual disease in a model of reversible pancreatic cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.126

BET bromodomain inhibition as a therapeutic strategy to target c-Myc

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.126

Targeting MYC dependence in cancer by inhibiting BET bromodomains

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.126

Inhibition of bromodomain proteins for the treatment of human diffuse large B-cell lymphoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.126

An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.126

c-Myc inhibition prevents leukemia initiation in mice and impairs the growth of relapsed and induction failure pediatric T-ALL cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.126

Selective inhibition of tumor oncogenes by disruption of super-enhancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.126

BET bromodomain inhibition of MYC-amplified medulloblastoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.126

Selective inhibition of BET bromodomains

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.126

Targeting MYCN in neuroblastoma by BET bromodomain inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.126

Inhibition of BET bromodomain targets genetically diverse glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.126

Development and histopathological characterization of tumorgraft models of pancreatic ductal adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.126

BET bromodomain inhibition targets both c-Myc and IL7R in high-risk acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.126

BET inhibition as a single or combined therapeutic approach in primary paediatric B-precursor acute lymphoblastic leukaemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.126

The machinery of macroautophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.126

Therapeutic targeting of c-Myc in T-cell acute lymphoblastic leukemia, T-ALL

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.126

Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.126

Regulation of MYC expression and differential JQ1 sensitivity in cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.126

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.126

Myc is required for activation of the ATM-dependent checkpoints in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.126

Enhancement of c-Myc degradation by BLM helicase leads to delayed tumor initiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.126

c-Myc activates BRCA1 gene expression through distal promoter elements in breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.126

MYC regulation of CHK1 and CHK2 promotes radioresistance in a stem cell-like population of nasopharyngeal carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.126

A DNA microarray screen for genes involved in c-MYC and N-MYC oncogenesis in human tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.126

Characterization of the c-MYC-regulated transcriptome by SAGE: identification and analysis of c-MYC target genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.126

HIF-1alpha induces genetic instability by transcriptionally downregulating MutSalpha expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.126

A global transcriptional regulatory role for c-Myc in Burkitt's lymphoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.126

Decreased origin usage and initiation of DNA replication in haploinsufficient HCT116 Ku80+/- cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.126

Repression of cyclin D1: a novel function of MYC

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.126

Myc represses the p21(WAF1/CIP1) promoter and interacts with Sp1/Sp3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.126

N-Myc is a downstream target of RET signaling and is required for transcriptional regulation of p18(Ink4c) by the transforming mutant RET(C634R).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.126

p19ARF directly and differentially controls the functions of c-Myc independently of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.126

Identification of CDK4 as a target of c-MYC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.126

c-Myc cooperates with activated Ras to induce the cdc2 promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.126

Cdc25 cell-cycle phosphatase as a target of c-myc

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.126

Efficacy of BET bromodomain inhibition in Kras-mutant non-small cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.126

CDC25 phosphatases as potential human oncogenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.126

Expression and functional significance of CDC25B in human pancreatic ductal adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.126

Characterisation of Cdc25B localisation and nuclear export during the cell cycle and in response to stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.126

BET bromodomain inhibitors block growth of pancreatic cancer cells in three-dimensional collagen

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.126

Sensitivity of human lung adenocarcinoma cell lines to targeted inhibition of BET epigenetic signaling proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.126

Small-molecule inhibition of BRDT for male contraception

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.126

A metastatic nude-mouse model of human pancreatic cancer constructed orthotopically with histologically intact patient specimens

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.126

Multi-color palette of fluorescent proteins for imaging the tumor microenvironment of orthotopic tumorgraft mouse models of clinical pancreatic cancer specimens

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.126

Efficacy of Salmonella typhimurium A1-R versus chemotherapy on a pancreatic cancer patient-derived orthotopic xenograft (PDOX).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.126

Metastatic recurrence in a pancreatic cancer patient derived orthotopic xenograft (PDOX) nude mouse model is inhibited by neoadjuvant chemotherapy in combination with fluorescence-guided surgery with an anti-CA 19-9-conjugated fluorophore

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.126

Efficacy of tumor-targeting Salmonella typhimurium A1-R in combination with anti-angiogenesis therapy on a pancreatic cancer patient-derived orthotopic xenograft (PDOX) and cell line mouse models.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.126

Direct multiplexed measurement of gene expression with color-coded probe pairs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.126

Investigation of the Alamar Blue (resazurin) fluorescent dye for the assessment of mammalian cell cytotoxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.126

Cluster analysis and display of genome-wide expression patterns

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.126

Myc suppression of the p21 Cip1 Cdk inhibitor influences the outcome of the p53 response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.126

c-MYC activation in primary and metastatic ductal adenocarcinoma of the pancreas: incidence, mechanisms, and clinical significance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.126

An epigenomic approach to therapy for tamoxifen-resistant breast cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.126

c-Myc represses transcription in vivo by a novel mechanism dependent on the initiator element and Myc box II

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.126

E2F1 and c-Myc in cell growth and death.

31 March 2020

1 reference

12 December 2020

Imageable fluorescent metastasis resulting in transgenic GFP mice orthotopically implanted with human-patient primary pancreatic cancer specimens.

1 reference

12 December 2020

Knockdown of Cdc25B in renal cell carcinoma is associated with decreased malignant features

1 reference

12 December 2020

Cytoplasmic accumulation of cdc25B phosphatase in mitosis triggers centrosomal microtubule nucleation in HeLa cells

1 reference

12 December 2020

Non-invasive fluorescent-protein imaging of orthotopic pancreatic-cancer-patient tumorgraft progression in nude mice.

1 reference

12 December 2020

Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67

1 reference

12 December 2020

Tumor-suppressive pathways in pancreatic carcinoma.

1 reference

12 December 2020

Bcl2 and p53 protein expression in metastatic carcinoma of unknown primary origin: biological and clinical implications. A Hellenic Co-operative Oncology Group study.

1 reference

12 December 2020

Identifiers

DOI

10.1038/ONC.2015.126

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25961927%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

7 March 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25961927%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

1 reference