(Q42708880)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24134204%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

title

A novel DYRK1B inhibitor AZ191 demonstrates that DYRK1B acts independently of GSK3β to phosphorylate cyclin D1 at Thr(286), not Thr(288) (English)

1 reference

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28 February 2020

0 references

6

1 reference

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28 February 2020

author name string

Anne L Ashford

1

1 reference

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28 February 2020

David Oxley

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24134204%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Jason Kettle

3

1 reference

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28 February 2020

Kevin Hudson

4

1 reference

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28 February 2020

Sylvie Guichard

5

1 reference

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28 February 2020

Pamela A Lochhead

7

1 reference

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28 February 2020

language of work or name

English

0 references

publication date

1 January 2014

1 reference

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28 February 2020

1 reference

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28 February 2020

volume

457

1 reference

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28 February 2020

issue

1

1 reference

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28 February 2020

page(s)

43-56

1 reference

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Identification of the autophosphorylation sites and characterization of their effects in the protein kinase DYRK1A

28 February 2020

cites work

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130461

Activation-loop autophosphorylation is mediated by a novel transitional intermediate form of DYRKs

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130461

Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130461

Mirk/dyrk1B is a Rho-induced kinase active in skeletal muscle differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130461

Cloning and characterization of DYRK1B, a novel member of the DYRK family of protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130461

Intersex-like (IXL) is a cell survival regulator in pancreatic cancer with 19q13 amplification

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130461

The selectivity of protein kinase inhibitors: a further update

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130461

Harmine specifically inhibits protein kinase DYRK1A and interferes with neurite formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130461

Specific inhibition of cyclin-dependent kinases and cell proliferation by harmine

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130461

Transforming p21ras mutants and c-Ets-2 activate the cyclin D1 promoter through distinguishable regions

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130461

D-type cyclin-dependent kinase activity in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130461

Cyclin D1 inhibits cell proliferation through binding to PCNA and cdk2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130461

Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130461

Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130461

Phosphorylation-dependent regulation of cyclin D1 nuclear export and cyclin D1-dependent cellular transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130461

Histone deacetylase inhibitor, trichostatin A induces ubiquitin-dependent cyclin D1 degradation in MCF-7 breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130461

Glycogen synthase kinase 3 has a limited role in cell cycle regulation of cyclin D1 levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130461

Rapid turnover of cell-cycle regulators found in Mirk/dyrk1B transfectants

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130461

Mirk/dyrk1B kinase destabilizes cyclin D1 by phosphorylation at threonine 288.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130461

ERK1/2 and p38 cooperate to delay progression through G1 by promoting cyclin D1 protein turnover.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130461

ERK1/2 and p38 cooperate to induce a p21CIP1-dependent G1 cell cycle arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130461

Extracellular signal-regulated kinases 1/2 are serum-stimulated "Bim(EL) kinases" that bind to the BH3-only protein Bim(EL) causing its phosphorylation and turnover

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130461

CDK1, not ERK1/2 or ERK5, is required for mitotic phosphorylation of BIMEL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130461

BIM(EL), an intrinsically disordered protein, is degraded by 20S proteasomes in the absence of poly-ubiquitylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130461

Sequence-specific and phosphorylation-dependent proline isomerization: a potential mitotic regulatory mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130461

Structures of the Dsk2 UBL and UBA domains and their complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130461

Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130461

The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130461

Cyclin D1 is a nuclear protein required for cell cycle progression in G1

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130461

The cyclin-dependent kinase inhibitor p27Kip1 is stabilized in G(0) by Mirk/dyrk1B kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130461

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130461

Mirk/Dyrk1B mediates survival during the differentiation of C2C12 myoblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130461

Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130461

Inactivation of mirk/dyrk1b kinase targets quiescent pancreatic cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130461

Ovarian cancer cells, not normal cells, are damaged by Mirk/Dyrk1B kinase inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130461

Involvement of GSK-3beta and DYRK1B in differentiation-inducing factor-3-induced phosphorylation of cyclin D1 in HeLa cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130461

The kinase DYRK phosphorylates protein-synthesis initiation factor eIF2Bepsilon at Ser539 and the microtubule-associated protein tau at Thr212: potential role for DYRK as a glycogen synthase kinase 3-priming kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130461

Phosphorylation of Ser640 in Muscle Glycogen Synthase by DYRK Family Protein Kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130461

Mirk regulates the exit of colon cancer cells from quiescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130461

Mirk/Dyrk1B, a novel therapeutic target, mediates cell survival in non-small cell lung cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130461

Mirk/Dyrk1B maintains the viability of quiescent pancreatic cancer cells by reducing levels of reactive oxygen species

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130461

Distinct Initiation and Maintenance Mechanisms Cooperate to Induce G1 Cell Cycle Arrest in Response to DNA Damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130461

21 January 2018

Identifiers

DOI

10.1042/BJ20130461

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24134204%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24134204%20AND%20SRC:MED&resulttype=core&format=json