(Q42732429)

6 November 2017

title

Gamma-secretase inhibitors target tumor-initiating cells in a mouse model of ERBB2 breast cancer (English)

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Erb-b2 receptor tyrosine kinase 2

6 November 2017

main subject

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M Kondratyev

1

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6 November 2017

A Kreso

2

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6 November 2017

R M Hallett

3

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6 November 2017

A Girgis-Gabardo

4

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6 November 2017

M E Barcelon

5

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6 November 2017

D Ilieva

6

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6 November 2017

C Ware

7

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6 November 2017

P K Majumder

8

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6 November 2017

J A Hassell

9

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6 November 2017

language of work or name

English

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publication date

13 June 2011

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6 November 2017

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6 November 2017

volume

31

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6 November 2017

issue

1

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6 November 2017

page(s)

93-103

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Notch signaling regulates mammary stem cell function and luminal cell-fate commitment.

6 November 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.212

The canonical Notch/RBP-J signaling pathway controls the balance of cell lineages in mammary epithelium during pregnancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.212

Hematopoietic stem cell fate is established by the Notch-Runx pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.212

Mammary cancer in humans and mice: a tutorial for comparative pathology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.212

Patterns of resistance and incomplete response to docetaxel by gene expression profiling in breast cancer patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.212

The tumor suppressor p53 regulates polarity of self-renewing divisions in mammary stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.212

Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.212

Targeting the Notch1 and mTOR pathways in a mouse T-ALL model

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.212

In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.212

Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.212

Downregulation of Notch pathway by a gamma-secretase inhibitor attenuates AKT/mammalian target of rapamycin signaling and glucose uptake in an ERBB2 transgenic breast cancer model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.212

Notch pathway inhibition depletes stem-like cells and blocks engraftment in embryonal brain tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.212

Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.212

Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.212

Cyclin D1 kinase activity is required for the self-renewal of mammary stem and progenitor cells that are targets of MMTV-ErbB2 tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.212

Implications of the cancer stem-cell hypothesis for breast cancer prevention and therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.212

Gamma-secretase inhibitor prevents Notch3 activation and reduces proliferation in human lung cancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.212

The canonical Notch signaling pathway: unfolding the activation mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.212

The Pea3 Ets transcription factor regulates differentiation of multipotent progenitor cells during mammary gland development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.212

Apoptosis in T cell acute lymphoblastic leukemia cells after cell cycle arrest induced by pharmacological inhibition of notch signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.212

Intrinsic resistance of tumorigenic breast cancer cells to chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.212

Enrichment of a population of mammary gland cells that form mammospheres and have in vivo repopulating activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.212

Progression to Malignancy in the Polyoma Middle T Oncoprotein Mouse Breast Cancer Model Provides a Reliable Model for Human Diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.212

Identification of tumorsphere- and tumor-initiating cells in HER2/Neu-induced mammary tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.212

The epithelial-mesenchymal transition generates cells with properties of stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.212

Inhibition of NOTCH signaling by gamma secretase inhibitor engages the RB pathway and elicits cell cycle exit in T-cell acute lymphoblastic leukemia cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.212

Transcriptome analysis of the normal human mammary cell commitment and differentiation process

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.212

Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.212

Pathway pathology: histological differences between ErbB/Ras and Wnt pathway transgenic mammary tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.212

Matrix metalloproteinase 7 controls pancreatic acinar cell transdifferentiation by activating the Notch signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.212

Novel activating mutations in the neu proto-oncogene involved in induction of mammary tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.212

Mutations affecting conserved cysteine residues within the extracellular domain of Neu promote receptor dimerization and activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.212

Clonal characterization of mouse mammary luminal epithelial and myoepithelial cells separated by fluorescence-activated cell sorting

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.212

Down-regulation of the Notch pathway mediated by a gamma-secretase inhibitor induces anti-tumour effects in mouse models of T-cell leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.212

Antagonistic roles of Notch and p63 in controlling mammary epithelial cell fates

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.212

Scale-up of breast cancer stem cell aggregate cultures to suspension bioreactors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.212

Large-scale expansion of mammary epithelial stem cell aggregates in suspension bioreactors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.212

Regulation of NOTCH signaling by reciprocal inhibition of HES1 and Deltex 1 and its role in osteosarcoma invasiveness

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.212

Metalloproteinases and cell fate: Notch just ADAMs anymore

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.212

The pea3 subfamily ets genes are required for HER2/Neu-mediated mammary oncogenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.212

31 March 2020

Identifiers

DOI

10.1038/ONC.2011.212

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Dimensions Publication ID

6 November 2017

1028785747

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1 reference