(Q42740555)

English

Optimization of the physicochemical and pharmacokinetic attributes in a 6-azauracil series of P2X7 receptor antagonists leading to the discovery of the clinical candidate CE-224,535.

scientific article published on 24 April 2011

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scholarly article

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31 January 2020

Optimization of the physicochemical and pharmacokinetic attributes in a 6-azauracil series of P2X7 receptor antagonists leading to the discovery of the clinical candidate CE-224,535 (English)

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31 January 2020

pharmacokinetics

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based on heuristic

inferred from title

Allen Duplantier

1

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author name string

Mark A Dombroski

2

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Chakrapani Subramanyam

3

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Aimee M Beaulieu

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Shang-Poa Chang

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Christopher A Gabel

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Crystal Jordan

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Amit S Kalgutkar

8

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Kenneth G Kraus

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Jeff M Labasi

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Christopher Mussari

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David G Perregaux

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Rick Shepard

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Timothy J Taylor

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Kristen A Trevena

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Carrie Whitney-Pickett

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Kwansik Yoon

17

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publication date

24 April 2011

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Bioorganic & Medicinal Chemistry Letters

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21

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3708-3711

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Identifiers

10.1016/J.BMCL.2011.04.077

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