(Q42746975)

6 November 2017

title

Nrf2/HO-1 pathway activation by manganese is associated with reactive oxygen species and ubiquitin-proteasome pathway, not MAPKs signaling (English)

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ubiquitin-proteasome system

6 November 2017

main subject

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reactive oxygen species

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Huangyuan Li

1

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6 November 2017

Siying Wu

2

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6 November 2017

Nian Shi

3

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6 November 2017

Shuangqing Lian

4

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6 November 2017

Wei Lin

5

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6 November 2017

language of work or name

English

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publication date

7 March 2011

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Journal of Applied Toxicology

6 November 2017

published in

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6 November 2017

volume

31

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6 November 2017

issue

7

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6 November 2017

page(s)

690-697

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Nrf2, a Cap'n'Collar transcription factor, regulates induction of the heme oxygenase-1 gene

6 November 2017

cites work

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Manganese: brain transport and emerging research needs

21 January 2018

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Manganese: recent advances in understanding its transport and neurotoxicity

21 January 2018

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Proteasome inhibition is associated with manganese-induced oxidative injury in PC12 cells

21 January 2018

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Nrf2 is essential for protection against acute pulmonary injury in mice

21 January 2018

1 reference

An important function of Nrf2 in combating oxidative stress: detoxification of acetaminophen

21 January 2018

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Manganese-induced potentiation of in vitro proinflammatory cytokine production by activated microglial cells is associated with persistent activation of p38 MAPK.

21 January 2018

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Manganese modulation of MAPK pathways: effects on upstream mitogen activated protein kinase kinases and mitogen activated kinase phosphatase-1 in microglial cells

21 January 2018

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Manganese-induced neurotoxicity is differentially enhanced by glutathione depletion in astrocytoma and neuroblastoma cells

21 January 2018

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Oxidative basis of manganese neurotoxicity

21 January 2018

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The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated hydroxyanisole and ethoxyquin

21 January 2018

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Manganese-induced apoptosis in PC12 cells.

21 January 2018

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Anti-apoptotic and pro-apoptotic effect of NEPP11 on manganese-induced apoptosis and JNK pathway activation in PC12 cells.

21 January 2018

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Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages

21 January 2018

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An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements

21 January 2018

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Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

21 January 2018

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Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles

21 January 2018

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Molecular mechanism activating Nrf2-Keap1 pathway in regulation of adaptive response to electrophiles

21 January 2018

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Induction of COX-2 in human airway cells by manganese: role of PI3K/PKB, p38 MAPK, PKCs, Src, and glutathione depletion

21 January 2018

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Nrf2 signaling in coordinated activation of antioxidant gene expression

21 January 2018

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Evolutionary conserved N-terminal domain of Nrf2 is essential for the Keap1-mediated degradation of the protein by proteasome

21 January 2018

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Mechanism of action of sulforaphane: inhibition of p38 mitogen-activated protein kinase isoforms contributing to the induction of antioxidant response element-mediated heme oxygenase-1 in human hepatoma HepG2 cells

21 January 2018

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Transcriptional regulation of the NAD(P)H:quinone oxidoreductase 1 and glutathione S-transferase ya genes by mercury, lead, and copper.

21 January 2018

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Enhanced expression of the transcription factor Nrf2 by cancer chemopreventive agents: role of antioxidant response element-like sequences in the nrf2 promoter

21 January 2018

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Stabilization of Nrf2 by tBHQ confers protection against oxidative stress-induced cell death in human neural stem cells

21 January 2018

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Carbon monoxide produced by heme oxygenase-1 in response to nitrosative stress induces expression of glutamate-cysteine ligase in PC12 cells via activation of phosphatidylinositol 3-kinase and Nrf2 signaling

21 January 2018

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Regulation of heme oxygenase-1 expression through the phosphatidylinositol 3-kinase/Akt pathway and the Nrf2 transcription factor in response to the antioxidant phytochemical carnosol

21 January 2018

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Manganese induces oxidative impairment in cultured rat astrocytes.

21 January 2018

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Inhibition and genetic deficiency of p38 MAPK up-regulates heme oxygenase-1 gene expression via Nrf2.

21 January 2018

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Regulatory mechanisms controlling gene expression mediated by the antioxidant response element

21 January 2018

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Increased protein stability as a mechanism that enhances Nrf2-mediated transcriptional activation of the antioxidant response element. Degradation of Nrf2 by the 26 S proteasome

21 January 2018

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The pathways and molecular mechanisms regulating Nrf2 activation in response to chemical stress

21 January 2018

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Nerve growth factor protects against 6-hydroxydopamine-induced oxidative stress by increasing expression of heme oxygenase-1 in a phosphatidylinositol 3-kinase-dependent manner

21 January 2018

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Nrf2 degradation by the ubiquitin proteasome pathway is inhibited by KIAA0132, the human homolog to INrf2

21 January 2018

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Degradation of transcription factor Nrf2 via the ubiquitin-proteasome pathway and stabilization by cadmium

21 January 2018

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Activation of MAP kinases by hexavalent chromium, manganese and nickel in human lung epithelial cells

21 January 2018

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Proteasomal inhibition induced by manganese ethylene-bis-dithiocarbamate: relevance to Parkinson's disease

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/JAT.1654

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6 November 2017

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