(Q42780390)

7 November 2017

Single- and multiple-dose pharmacokinetics of bosentan and its interaction with ketoconazole (English)

1 reference

7 November 2017

1 reference

Paul L M van Giersbergen

series ordinal

1

1 reference

7 November 2017

Atef Halabi

series ordinal

2

1 reference

7 November 2017

Jasper Dingemanse

series ordinal

3

1 reference

7 November 2017

language of work or name

English

0 references

publication date

1 June 2002

1 reference

British Journal of Clinical Pharmacology

7 November 2017

1 reference

7 November 2017

53

1 reference

7 November 2017

6

1 reference

7 November 2017

589-595

1 reference

Bosentan and the endothelin system in congestive heart failure.

7 November 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1874330

Update: clinically significant cytochrome P-450 drug interactions

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1874330

Pharmacological characterization of bosentan, a new potent orally active nonpeptide endothelin receptor antagonist

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1874330

Effects of ketoconazole on the polymorphic 4-hydroxylations of S-mephenytoin and debrisoquine

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1874330

The increase in urinary excretion of 6 beta-hydroxycortisol as a marker of human hepatic cytochrome P450IIIA induction

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1874330

Pharmacokinetics of the newer benzodiazepines

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1874330

A novel potent vasoconstrictor peptide produced by vascular endothelial cells

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1874330

Effects of the dual endothelin-receptor antagonist bosentan in patients with pulmonary hypertension: a randomised placebo-controlled study

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1874330

Cytochrome P450 3A4 in vivo ketoconazole competitive inhibition: determination of Ki and dangers associated with high clearance drugs in general.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1874330

Differentiation of intestinal and hepatic cytochrome P450 3A activity with use of midazolam as an in vivo probe: effect of ketoconazole.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1874330

Pharmacokinetics and pharmacodynamics of the endothelin-receptor antagonist bosentan in healthy human subjects.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1874330

Evidence for endothelin-1-mediated vasoconstriction in severe chronic heart failure.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1874330

?ndothelin: new discoveries and rapid progress in the clinic

16 August 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2125.2002.01608.X

The endothelin family of peptides: local hormones with diverse roles in health and disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2125.2002.01608.X

Multiple-dose pharmacokinetics, safety, and tolerability of bosentan, an endothelin receptor antagonist, in healthy male volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2125.2002.01608.X

Simultaneous determination of bosentan and its three major metabolites in various biological matrices and species using narrow bore liquid chromatography with ion spray tandem mass spectrometric detection

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2125.2002.01608.X

Urinary excretion of 6 beta-hydroxycortisol and the time course measurement of enzyme induction in man

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2125.2002.01608.X

Effect of the endothelin-receptor antagonist bosentan on the pharmacokinetics and pharmacodynamics of warfarin

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2125.2002.01608.X

Renal hemodynamics and pharmacokinetics of bosentan with and without cyclosporine A

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2125.2002.01608.X

The effect of ketoconazole on the pharmacokinetics, pharmacodynamics and safety of nisoldipine

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2125.2002.01608.X

Effect of ketoconazole on hepatic oxidative drug metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2125.2002.01608.X

Update of REACH-1 and MERIT-HF clinical trials in heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2125.2002.01608.X

Terfenadine-ketoconazole interaction. Pharmacokinetic and electrocardiographic consequences

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/12047483

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Absorption, excretion, and metabolism of the endothelin receptor antagonist bosentan in healthy male subjects

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/12047483

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1046/J.1365-2125.2002.01608.X

1 reference

7 November 2017

1 reference

7 November 2017

PubMed publication ID

12047483

1 reference