(Q42799900)

7 November 2017

Point mutants of c-raf-1 RBD with elevated binding to v-Ha-Ras (English)

1 reference

7 November 2017

Fridman M

1

1 reference

7 November 2017

Maruta H

2

1 reference

7 November 2017

Gonez J

3

1 reference

7 November 2017

Walker F

4

1 reference

7 November 2017

Treutlein H

5

1 reference

7 November 2017

Zeng J

6

1 reference

7 November 2017

Burgess A

7

1 reference

7 November 2017

language of work or name

English

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publication date

1 September 2000

1 reference

Journal of Biological Chemistry

7 November 2017

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7 November 2017

275

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7 November 2017

39

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7 November 2017

30363-30371

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The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue

7 November 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003193200

Identification of murine homologues of the Drosophila son of sevenless gene: potential activators of ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003193200

Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003193200

Ras effectors and their role in mitogenesis and oncogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003193200

Increasing complexity of Ras signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003193200

Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003193200

Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003193200

Complexes of Ras.GTP with Raf-1 and mitogen-activated protein kinase kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003193200

Serine- and threonine-specific protein kinase activities of purified gag-mil and gag-raf proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003193200

Raf-1 forms a stable complex with Mek1 and activates Mek1 by serine phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003193200

Mammalian Ras interacts directly with the serine/threonine kinase Raf

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003193200

Solution structure of the Ras-binding domain of c-Raf-1 and identification of its Ras interaction surface

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003193200

A single amino acid change in Raf-1 inhibits Ras binding and alters Raf-1 function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003193200

Protein-protein recognition: an experimental and computational study of the R89K mutation in Raf and its effect on Ras binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003193200

Nuclear magnetic resonance and molecular dynamics studies on the interactions of the Ras-binding domain of Raf-1 with wild-type and mutant Ras proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003193200

Ras/Rap effector specificity determined by charge reversal

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003193200

Mitogenic signaling of Ras is regulated by differential interaction with Raf isozymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003193200

Rapid Ca2+-mediated activation of Rap1 in human platelets

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003193200

Activation of the small GTPase Ral in platelets.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003193200

Minimal Ras-binding domain of Raf1 can be used as an activation-specific probe for Ras.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003193200

Quantitative analysis of the complex between p21ras and the Ras-binding domain of the human Raf-1 protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003193200

Dominant inhibitory Ras mutants selectively inhibit the activity of either cellular or oncogenic Ras.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003193200

Selection of phage-displayed fab antibodies on the active conformation of ras yields a high affinity conformation-specific antibody preventing the binding of c-Raf kinase to Ras.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003193200

Solubilization and purification of enzymatically active glutathione S-transferase (pGEX) fusion proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003193200

Recombinant proteins can be isolated from E. coli cells by repeated cycles of freezing and thawing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003193200

Intrinsic GTPase activity distinguishes normal and oncogenic ras p21 molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003193200

Activation of the Ras/mitogen-activated protein kinase pathway by kinase-defective epidermal growth factor receptors results in cell survival but not proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003193200

Epidermal growth factor regulates the exchange rate of guanine nucleotides on p21ras in fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003193200

Discrimination of amino acids mediating Ras binding from noninteracting residues affecting raf activation by double mutant analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003193200

Conformation of the Ras-binding domain of Raf studied by molecular dynamics and free energy simulations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003193200

Purification of baculovirus-expressed recombinant Ras and Rap proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003193200

The p21 ras C-terminus is required for transformation and membrane association

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003193200

Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003193200

All ras proteins are polyisoprenylated but only some are palmitoylated

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003193200

Protein isoprenylation and methylation at carboxyl-terminal cysteine residues

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003193200

Cloning and characterization of a mammalian prenyl protein-specific protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003193200

Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003193200

Ras p21 proteins with high or low GTPase activity can efficiently transform NIH/3T3 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003193200

Guanosine triphosphatase activating protein (GAP) interacts with the p21 ras effector binding domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003193200

Mutant ras-encoded proteins with altered nucleotide binding exert dominant biological effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003193200

Function and regulation of ras.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003193200

Insulin and epidermal growth factor receptors regulate distinct pools of Grb2-SOS in the control of Ras activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003193200

Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003193200

Epidermal-growth-factor receptors generate Ras.GTP more efficiently than insulin receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003193200

Critical binding and regulatory interactions between Ras and Raf occur through a small, stable N-terminal domain of Raf and specific Ras effector residues

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003193200

The interaction of Ras with GTPase-activating proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003193200

Conformational transitions in p21ras and in its complexes with the effector protein Raf-RBD and the GTPase activating protein GAP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003193200

Regional polysterism in the GTP-bound form of the human c-Ha-Ras protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003193200

Equilibrium and kinetic measurements reveal rapidly reversible binding of Ras to Raf.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003193200

The differential effects of the Gly-60 to Ala mutation on the interaction of H-Ras p21 with different downstream targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003193200

Functional consequences of monoglucosylation of Ha-Ras at effector domain amino acid threonine 35.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003193200

Inhibition of Ras/Raf interaction by anti-oncogenic mutants of neurofibromin, the neurofibromatosis type 1 (NF1) gene product, in cell-free systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003193200

The significance of DNA and protein adducts in human biomonitoring studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003193200

Quantitative structure-activity analysis correlating Ras/Raf interaction in vitro to Raf activation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003193200

Selective inhibition of Ras interaction with its particular effector by synthetic peptides corresponding to the Ras effector region

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003193200

Transient Kinetic Studies on the Interaction of Ras and the Ras-Binding Domain of c-Raf-1 Reveal Rapid Equilibration of the Complex†

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M003193200

21 January 2018

Identifiers

DOI

10.1074/JBC.M003193200

1 reference

7 November 2017

1 reference