(Q42825786)

8 November 2017

title

Regulation of insulin/insulin-like growth factor-1 signaling by proteasome-mediated degradation of insulin receptor substrate-2. (English)

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8 November 2017

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Rui L

1

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8 November 2017

Fisher TL

series ordinal

2

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8 November 2017

Thomas J

series ordinal

3

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8 November 2017

White MF

series ordinal

4

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8 November 2017

language of work or name

English

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publication date

23 August 2001

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Journal of Biological Chemistry

8 November 2017

published in

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8 November 2017

volume

276

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8 November 2017

issue

43

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8 November 2017

page(s)

40362-40367

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The IRS-signalling system during insulin and cytokine action

8 November 2017

cites work

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https://api.crossref.org/works/10.1074%2FJBC.M105332200

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Signaling pathways in insulin action: molecular targets of insulin resistance

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Cellular mechanisms of insulin resistance

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Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1.

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Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene.

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Disruption of IRS-2 causes type 2 diabetes in mice

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Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene

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Regulation of the insulin signalling pathway by cellular protein-tyrosine phosphatases

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Mechanisms of TNF-alpha-induced insulin resistance

21 January 2018

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Tumor necrosis factor-alpha-induced insulin resistance in 3T3-L1 adipocytes is accompanied by a loss of insulin receptor substrate-1 and GLUT4 expression without a loss of insulin receptor-mediated signal transduction.

21 January 2018

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Persistent activation of phosphatidylinositol 3-kinase causes insulin resistance due to accelerated insulin-induced insulin receptor substrate-1 degradation in 3T3-L1 adipocytes

21 January 2018

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Insulin-induced insulin receptor substrate-1 degradation is mediated by the proteasome degradation pathway.

21 January 2018

1 reference

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Insulin-like growth factor I-induced degradation of insulin receptor substrate 1 is mediated by the 26S proteasome and blocked by phosphatidylinositol 3'-kinase inhibition

21 January 2018

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The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B

21 January 2018

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Intracellular proteolysis

21 January 2018

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The ubiquitin-proteasome pathway: the complexity and myriad functions of proteins death

21 January 2018

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The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro

21 January 2018

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Signal-induced ubiquitination of IkappaBalpha by the F-box protein Slimb/beta-TrCP

21 January 2018

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Substrate targeting in the ubiquitin system

21 January 2018

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Target of rapamycin (TOR): balancing the opposing forces of protein synthesis and degradation

21 January 2018

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Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway

21 January 2018

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Immunopurified mammalian target of rapamycin phosphorylates and activates p70 S6 kinase alpha in vitro

21 January 2018

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Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation.

21 January 2018

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Differential regulation of insulin receptor substrates-1 and -2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse

21 January 2018

1 reference

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Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice

21 January 2018

1 reference

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Alterations of proteasome activities in skeletal muscle tissue of diabetic rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105332200

The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307)

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105332200

Phosphorylation of insulin receptor substrate-1 on multiple serine residues, 612, 632, 662, and 731, modulates insulin action

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105332200

IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105332200

Serine/threonine phosphorylation of IRS-1 triggers its degradation: possible regulation by tyrosine phosphorylation

21 January 2018

1 reference

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IRS-2 pathways integrate female reproduction and energy homeostasis

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1074/JBC.M105332200

1 reference

8 November 2017

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