(Q42826655)

8 November 2017

title

Mishandling of the therapeutic peptide glucagon generates cytotoxic amyloidogenic fibrils (English)

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8 November 2017

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Satomi Onoue

1

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8 November 2017

Keiichi Ohshima

2

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8 November 2017

Kazuhiro Debari

3

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8 November 2017

Keitatsu Koh

4

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8 November 2017

Seiji Shioda

5

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8 November 2017

Sumiko Iwasa

6

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8 November 2017

Kazuhisa Kashimoto

7

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8 November 2017

Takehiko Yajima

8

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8 November 2017

publication date

1 July 2004

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8 November 2017

published in

Pharmaceutical Research

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8 November 2017

volume

21

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8 November 2017

issue

7

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8 November 2017

page(s)

1274-1283

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Immunization against Alzheimer's beta -amyloid plaques via EFRH phage administration

8 November 2017

cites work

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Thioflavine T interaction with synthetic Alzheimer's disease beta-amyloid peptides: detection of amyloid aggregation in solution

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12 December 2020

Formation and Structure of Gels and Fibrils from Glucagon

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12 December 2020

The neuromodulatory effects of VIP/PACAP on PC-12 cells are associated with their N-terminal structures

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Amyloid deposits and amyloidosis: the beta-fibrilloses (second of two parts).

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12 December 2020

Computed circular dichroism spectra for the evaluation of protein conformation

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Aggregation pathway of recombinant human keratinocyte growth factor and its stabilization

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Amino acid composition of salmon calcitonin.

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12 December 2020

Conformational transitions and fibrillation mechanism of human calcitonin as studied by high-resolution solid-state 13C NMR

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Neurotoxicity of a prion protein fragment

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12 December 2020

Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients

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12 December 2020

Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo

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12 December 2020

Effects of non-covalent self-association on the subcutaneous absorption of a therapeutic peptide.

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12 December 2020

Monoclonal antibodies inhibit in vitro fibrillar aggregation of the Alzheimer beta-amyloid peptide

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12 December 2020

Cytotoxic T lymphocyte-assisted suicide. Caspase 3 activation is primarily the result of the direct action of granzyme B.

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12 December 2020

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

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12 December 2020

The reaction of glucagon with its receptor: evidence for discrete regions of activity and binding in the glucagon molecule

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12 December 2020

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12 December 2020

The neuropeptide PACAP attenuates beta-amyloid (1-42)-induced toxicity in PC12 cells

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12 December 2020

Immunomodulation of the human prion peptide 106-126 aggregation

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12 December 2020

Cross- protein structures. I. Insulin fibrils

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12 December 2020

Binding of the dye congo red to the amyloid protein pig insulin reveals a novel homology amongst amyloid-forming peptide sequences

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12 December 2020

Comparison of the aggregation properties, secondary structure and apoptotic effects of wild-type, Flemish and Dutch N-terminally truncated amyloid beta peptides

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12 December 2020

Amyloidogenic determinant as a substrate recognition motif of insulin-degrading enzyme

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12 December 2020

Cyclic nucleotides suppress tumor necrosis factor alpha-mediated apoptosis by inhibiting caspase activation and cytochrome c release in primary hepatocytes via a mechanism independent of Akt activation

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12 December 2020

Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins

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12 December 2020

Medicine: danger--misfolding proteins.

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12 December 2020

Enhancement of MTT, a tetrazolium salt, exocytosis by amyloid beta-protein and chloroquine in cultured rat astrocytes

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Quantitative evaluation of congo red binding to amyloid-like proteins with a beta-pleated sheet conformation

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12 December 2020

Two simple methods for quantifying low-affinity dye-substrate binding.

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12 December 2020

Amyloid deposits and amyloidosis. The beta-fibrilloses (first of two parts).

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12 December 2020

Solid-phase peptide synthesis

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12 December 2020

Structure of Porcine Secretin. The Amino Acid Sequence

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12 December 2020

X-ray analysis of glucagon and its relationship to receptor binding

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12 December 2020

Alzheimer's disease--from cause to cure?

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12 December 2020

PACAP protects neuronal PC12 cells from the cytotoxicity of human prion protein fragment 106-126.

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12 December 2020

Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis

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12 December 2020

Beta-structure in human amylin and two designer beta-peptides: CD and NMR spectroscopic comparisons suggest soluble beta-oligomers and the absence of significant populations of beta-strand dimers

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12 December 2020

Steroid hormones block amyloid fibril-induced 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) formazan exocytosis: relationship to neurotoxicity.

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12 December 2020

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12 December 2020

Cyclic-AMP inhibits nitric oxide-induced apoptosis in human osteoblast: the regulation of caspase-3, -6, -9 and the release of cytochrome c in nitric oxide-induced apoptosis by cAMP.

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12 December 2020

10.1023/B:PHAM.0000033016.36825.2C

Identifiers

DOI

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8 November 2017

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