(Q42830960)

English

Akt stimulates the transactivation potential of the RelA/p65 Subunit of NF-kappa B through utilization of the Ikappa B kinase and activation of the mitogen-activated protein kinase p38.

scientific article published on 20 March 2001

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scholarly article

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Europe PubMed Central

8 November 2017

Akt stimulates the transactivation potential of the RelA/p65 Subunit of NF-kappa B through utilization of the Ikappa B kinase and activation of the mitogen-activated protein kinase p38. (English)

1 reference

Europe PubMed Central

8 November 2017

1 reference

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author name string

L V Madrid

1

1 reference

Europe PubMed Central

8 November 2017

M W Mayo

2

1 reference

Europe PubMed Central

8 November 2017

J Y Reuther

3

1 reference

Europe PubMed Central

8 November 2017

A S Baldwin

4

1 reference

Europe PubMed Central

8 November 2017

language of work or name

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publication date

20 March 2001

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Europe PubMed Central

8 November 2017

Journal of Biological Chemistry

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Europe PubMed Central

8 November 2017

276

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Europe PubMed Central

8 November 2017

18934-18940

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Europe PubMed Central

8 November 2017

22

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Europe PubMed Central

8 November 2017

Mechanisms and consequences of activation of protein kinase B/Akt

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101103200

21 January 2018

Cellular survival: a play in three Akts

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101103200

21 January 2018

The akt kinase: molecular determinants of oncogenicity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101103200

21 January 2018

Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101103200

21 January 2018

AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101103200

21 January 2018

Akt is a direct target of the phosphatidylinositol 3-kinase. Activation by growth factors, v-src and v-Ha-ras, in Sf9 and mammalian cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101103200

21 January 2018

Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-kappaB.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101103200

21 January 2018

HER-2/neu blocks tumor necrosis factor-induced apoptosis via the Akt/NF-kappaB pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101103200

21 January 2018

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101103200

21 January 2018

Regulation of cell death protease caspase-9 by phosphorylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101103200

21 January 2018

Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101103200

21 January 2018

Regulation of neuronal survival by the serine-threonine protein kinase Akt

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101103200

21 January 2018

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101103200

21 January 2018

Direct control of the Forkhead transcription factor AFX by protein kinase B

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101103200

21 January 2018

Negative regulation of the forkhead transcription factor FKHR by Akt.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101103200

21 January 2018

NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101103200

21 January 2018

NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101103200

21 January 2018

Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-kappaB p65/RelA subunit

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101103200

21 January 2018

Induction of NF-kappaB by the Akt/PKB kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101103200

21 January 2018

NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101103200

21 January 2018

The NF-kappa B and I kappa B proteins: new discoveries and insights

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101103200

21 January 2018

Mapping of the inducible IkappaB phosphorylation sites that signal its ubiquitination and degradation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101103200

21 January 2018

Bridging the gap: composition, regulation, and physiological function of the IkappaB kinase complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101103200

21 January 2018

IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101103200

21 January 2018

The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101103200

21 January 2018

Activation of nuclear factor-kappaB-dependent transcription by tumor necrosis factor-alpha is mediated through phosphorylation of RelA/p65 on serine 529.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101103200

21 January 2018

Phosphorylation of NF-kappa B p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101103200

21 January 2018

The transcriptional activity of NF-kappaB is regulated by the IkappaB-associated PKAc subunit through a cyclic AMP-independent mechanism

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101103200

21 January 2018

Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101103200

21 January 2018

Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-kappaB-dependent gene transcription

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101103200

21 January 2018

Activation of transcription factor NF-kappaB and p38 mitogen-activated protein kinase is mediated by distinct and separate stress effector pathways

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101103200

21 January 2018

IkappaBalpha degradation and nuclear factor-kappaB DNA binding are insufficient for interleukin-1beta and tumor necrosis factor-alpha-induced kappaB-dependent transcription. Requirement for an additional activation pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101103200

21 January 2018

Kinase regulation in inflammatory response

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101103200

21 January 2018

Tumor necrosis factor alpha-induced phosphorylation of RelA/p65 on Ser529 is controlled by casein kinase II

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101103200

21 January 2018

IkappaB kinases phosphorylate NF-kappaB p65 subunit on serine 536 in the transactivation domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101103200

21 January 2018

A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101103200

21 January 2018

Protein kinase B and rac are activated in parallel within a phosphatidylinositide 3OH-kinase-controlled signaling pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101103200

21 January 2018

Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101103200

21 January 2018

Requirement of NF-kappaB activation to suppress p53-independent apoptosis induced by oncogenic Ras.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101103200

21 January 2018

Oncogenic Ras enhances NF-kappaB transcriptional activity through Raf-dependent and Raf-independent mitogen-activated protein kinase signaling pathways

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101103200

21 January 2018

p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways are required for nuclear factor-kappaB p65 transactivation mediated by tumor necrosis factor.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101103200

21 January 2018

Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101103200

21 January 2018

The pyridinyl imidazole inhibitor SB203580 blocks phosphoinositide-dependent protein kinase activity, protein kinase B phosphorylation, and retinoblastoma hyperphosphorylation in interleukin-2-stimulated T cells independently of p38 mitogen-activate

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101103200

21 January 2018

Transcriptional activation by NF-kappaB requires multiple coactivators

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101103200

21 January 2018

The Akt proto-oncogene links Ras to Pak and cell survival signals

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101103200

21 January 2018

p38 MAPK and NF-kappa B collaborate to induce interleukin-6 gene expression and release. Evidence for a cytoprotective autocrine signaling pathway in a cardiac myocyte model system

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101103200

21 January 2018

Identifiers

10.1074/JBC.M101103200

1 reference

Europe PubMed Central

8 November 2017

1 reference

Europe PubMed Central

8 November 2017

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