(Q42835600)

English

Pharmacokinetics and pharmacodynamics of single rising intravenous doses (0.5 mg-10 mg) and determination of absolute bioavailability of the dipeptidyl peptidase-4 inhibitor linagliptin (BI 1356) in healthy male subjects

scientific article published on December 2010

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scholarly article

1 reference

Europe PubMed Central

8 November 2017

Pharmacokinetics and pharmacodynamics of single rising intravenous doses (0.5 mg-10 mg) and determination of absolute bioavailability of the dipeptidyl peptidase-4 inhibitor linagliptin (BI 1356) in healthy male subjects (English)

1 reference

Europe PubMed Central

8 November 2017

1 reference

ChEBI release 2020-05-28

bioavailability

1 reference

based on heuristic

inferred from title

pharmacokinetics

1 reference

based on heuristic

inferred from title

pharmacodynamics

1 reference

based on heuristic

inferred from title

author name string

Silke Retlich

1

1 reference

Europe PubMed Central

8 November 2017

Vincent Duval

2

1 reference

Europe PubMed Central

8 November 2017

Arne Ring

3

1 reference

Europe PubMed Central

8 November 2017

Arne Ring

4

1 reference

Europe PubMed Central

8 November 2017

Alexander Staab

5

1 reference

Europe PubMed Central

8 November 2017

Silke Hüttner

6

1 reference

Europe PubMed Central

8 November 2017

Arvid Jungnik

7

1 reference

Europe PubMed Central

8 November 2017

Ulrich Jaehde

8

1 reference

Europe PubMed Central

8 November 2017

Klaus A Dugi

9

1 reference

Europe PubMed Central

8 November 2017

Ulrike Graefe-Mody

10

1 reference

Europe PubMed Central

8 November 2017

language of work or name

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based on heuristic

inferred from title

publication date

1 December 2010

1 reference

Europe PubMed Central

8 November 2017

Clinical Pharmacokinetics

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Europe PubMed Central

8 November 2017

49

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Europe PubMed Central

8 November 2017

12

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Europe PubMed Central

8 November 2017

829-840

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Europe PubMed Central

8 November 2017

https://scigraph.springernature.com/pub.10.2165/11536620-000000000-00000

0 references

(R)-8-(3-amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione (BI 1356), a novel xanthine-based dipeptidyl peptidase 4 inhibitor, has a superior potency and longer duration of action compared wi

1 reference

https://pubmed.ncbi.nlm.nih.gov/21053992

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bioavailability and its assessment.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21053992

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of glucagon-like peptide 1 on fasting glycemia in type 2 diabetic patients treated with insulin after sulfonylurea secondary failure.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21053992

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The absolute oral bioavailability and population-based pharmacokinetic modelling of a novel dipeptidylpeptidase-IV inhibitor, vildagliptin, in healthy volunteers.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21053992

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucagon-like peptide-1 (7-36)amide and glucose-dependent insulinotropic polypeptide secretion in response to nutrient ingestion in man: acute post-prandial and 24-h secretion patterns.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21053992

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasma dipeptidyl peptidase-IV activity in patients with type-2 diabetes mellitus correlates positively with HbAlc levels, but is not acutely affected by food intake.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21053992

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetic, pharmacodynamic, and tolerability profiles of the dipeptidyl peptidase-4 inhibitor alogliptin: a randomized, double-blind, placebo-controlled, multiple-dose study in adult patients with type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/21053992

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Concentration-dependent plasma protein binding of the novel dipeptidyl peptidase 4 inhibitor BI 1356 due to saturable binding to its target in plasma of mice, rats and humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/21053992

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics, pharmacodynamics and tolerability of multiple oral doses of linagliptin, a dipeptidyl peptidase-4 inhibitor in male type 2 diabetes patients.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21053992

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

8-(3-(R)-aminopiperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydropurine-2,6-dione (BI 1356), a highly potent, selective, long-acting, and orally bioavailable DPP-4 inhibitor for the treatment of type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/21053992

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hyperglycaemia increases dipeptidyl peptidase IV activity in diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/21053992

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Additive insulinotropic effects of exogenous synthetic human gastric inhibitory polypeptide and glucagon-like peptide-1-(7-36) amide infused at near-physiological insulinotropic hormone and glucose concentrations

1 reference

https://pubmed.ncbi.nlm.nih.gov/21053992

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of human serum dipeptidyl peptidase IV (CD26) and analysis of its autoantibodies in patients with rheumatoid arthritis and other autoimmune diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/21053992

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A nonlabeled method to evaluate cortisol production rate by modeling plasma CBG-free cortisol disposition.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21053992

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Benazeprilat disposition and effect in dogs revisited with a pharmacokinetic/pharmacodynamic modeling approach.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21053992

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Estimation of the absolute bioavailability of rivastigmine in patients with mild to moderate dementia of the Alzheimer's type

1 reference

https://pubmed.ncbi.nlm.nih.gov/21053992

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Safety, tolerability, pharmacokinetics, and pharmacodynamics of single oral doses of BI 1356, an inhibitor of dipeptidyl peptidase 4, in healthy male volunteers

1 reference

https://pubmed.ncbi.nlm.nih.gov/21053992

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucagon-like peptide-1 7-36: a physiological incretin in man.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21053992

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetic/pharmacodynamic modelling of the disposition and effect of benazepril and benazeprilat in cats

1 reference

https://pubmed.ncbi.nlm.nih.gov/21053992

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dipeptidyl peptidase IV inhibition for the treatment of type 2 diabetes: potential importance of selectivity over dipeptidyl peptidases 8 and 9.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21053992

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quasi-equilibrium pharmacokinetic model for drugs exhibiting target-mediated drug disposition.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21053992

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in type 2 (non-insulin-dependent) diabetic patients.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21053992

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preoperative serum CD26 levels: diagnostic efficiency and predictive value for colorectal cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/21053992

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics of cefixime after oral and intravenous doses in dogs: bioavailability assessment for a drug showing nonlinear serum protein binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/21053992

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impact of target-mediated drug disposition on Linagliptin pharmacokinetics and DPP-4 inhibition in type 2 diabetic patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/21053992

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucose-lowering activity of the dipeptidyl peptidase-4 inhibitor saxagliptin in drug-naive patients with type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/21053992

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of Single Oral Doses of Sitagliptin, a Dipeptidyl Peptidase-4 Inhibitor, on Incretin and Plasma Glucose Levels after an Oral Glucose Tolerance Test in Patients with Type 2 Diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/21053992

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.2165/11536620-000000000-00000

1 reference

Europe PubMed Central

8 November 2017

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0 references

1 reference

Europe PubMed Central

8 November 2017

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