(Q42844930)

English

Redesign of the substrate specificity of Escherichia coli aspartate aminotransferase to that of Escherichia coli tyrosine aminotransferase by homology modeling and site-directed mutagenesis

scientific article published on September 1995

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scholarly article

1 reference

Europe PubMed Central

8 November 2017

Redesign of the substrate specificity of Escherichia coli aspartate aminotransferase to that of Escherichia coli tyrosine aminotransferase by homology modeling and site-directed mutagenesis (English)

1 reference

Europe PubMed Central

8 November 2017

Escherichia coli

1 reference

based on heuristic

inferred from title

author name string

J J Onuffer

1

1 reference

Europe PubMed Central

8 November 2017

J F Kirsch

2

1 reference

Europe PubMed Central

8 November 2017

publication date

1 September 1995

1 reference

Europe PubMed Central

8 November 2017

Protein Science

1 reference

Europe PubMed Central

8 November 2017

4

1 reference

Europe PubMed Central

8 November 2017

1750-1757

1 reference

Europe PubMed Central

8 November 2017

9

1 reference

Europe PubMed Central

8 November 2017

The use of natural and unnatural amino acid substrates to define the substrate specificity differences of Escherichia coli aspartate and tyrosine aminotransferases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2143225

27 May 2018

Aminotransferases: demonstration of homology and division into evolutionary subgroups.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2143225

27 May 2018

Structure of the complex between pyridoxal 5'-phosphate and the tyrosine 225 to phenylalanine mutant of Escherichia coli aspartate aminotransferase determined by isotope-edited classical Raman difference spectroscopy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2143225

27 May 2018

Crystal structures of Escherichia coli aspartate aminotransferase in two conformations. Comparison of an unliganded open and two liganded closed forms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2143225

27 May 2018

Alternating arginine-modulated substrate specificity in an engineered tyrosine aminotransferase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2143225

27 May 2018

Mechanism of action of aspartate aminotransferase proposed on the basis of its spatial structure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2143225

27 May 2018

Measurement of protein by spectrophotometry at 205 nm.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2143225

27 May 2018

Engineering an enzyme by site-directed mutagenesis to be resistant to chemical oxidation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2143225

27 May 2018

Designing substrate specificity by protein engineering of electrostatic interactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2143225

27 May 2018

Rapid and efficient site-specific mutagenesis without phenotypic selection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2143225

27 May 2018

Role of arginine-292 in the substrate specificity of aspartate aminotransferase as examined by site-directed mutagenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2143225

27 May 2018

Large increases in general stability for subtilisin BPN' through incremental changes in the free energy of unfolding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2143225

27 May 2018

Redesign of the coenzyme specificity of a dehydrogenase by protein engineering

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2143225

27 May 2018

Engineering subtilisin and its substrates for efficient ligation of peptide bonds in aqueous solution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2143225

27 May 2018

The open/closed conformational equilibrium of aspartate aminotransferase. Studies in the crystalline state and with a fluorescent probe in solution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2143225

27 May 2018

Activity and structure of the active-site mutants R386Y and R386F of Escherichia coli aspartate aminotransferase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2143225

27 May 2018

The tyrosine-225 to phenylalanine mutation of Escherichia coli aspartate aminotransferase results in an alkaline transition in the spectrophotometric and kinetic pKa values and reduced values of both kcat and Km.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2143225

27 May 2018

Engineering the substrate specificity of glutathione reductase toward that of trypanothione reduction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2143225

27 May 2018

Converting trypsin to chymotrypsin: the role of surface loops

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2143225

27 May 2018

Amino Acid Biosynthesis and its Regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2143225

27 May 2018

Replacement of an interdomain residue Val39 of Escherichia coli aspartate aminotransferase affects the catalytic competence without altering the substrate specificity of the enzyme.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2143225

27 May 2018

Computational approach towards the three-dimensional structure of E. coli tyrosine aminotransferase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2143225

27 May 2018

Characterization of the apparent negative co-operativity induced in Escherichia coli aspartate aminotransferase by the replacement of Asp222 with alanine. Evidence for an extremely slow conformational change

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2143225

16 August 2018

Three-dimensional structure of a mutant E. coli aspartate aminotransferase with increased enzymic activity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2143225

16 August 2018

Why ion pair reversal by protein engineering is unlikely to succeed

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2143225

3 November 2018

Glutamic-aspartic transaminase. IX. Equilibria with glutamate and alpha-ketoglutarate

1 reference

https://pubmed.ncbi.nlm.nih.gov/8528073

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteases of enhanced stability: characterization of a thermostable variant of subtilisin

1 reference

https://pubmed.ncbi.nlm.nih.gov/8528073

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A specific, highly active malate dehydrogenase by redesign of a lactate dehydrogenase framework

1 reference

https://pubmed.ncbi.nlm.nih.gov/8528073

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[Arg292----Val] or [Arg292----Leu] mutation enhances the reactivity of Escherichia coli aspartate aminotransferase with aromatic amino acids

1 reference

https://pubmed.ncbi.nlm.nih.gov/8528073

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Improvement in the alkaline stability of subtilisin using an efficient random mutagenesis and screening procedure

1 reference

https://pubmed.ncbi.nlm.nih.gov/8528073

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evolutionary relationships among aminotransferases. Tyrosine aminotransferase, histidinol-phosphate aminotransferase, and aspartate aminotransferase are homologous proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/8528073

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A single amino acid substitution in lactate dehydrogenase improves the catalytic efficiency with an alternative coenzyme

1 reference

https://pubmed.ncbi.nlm.nih.gov/8528073

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Design and synthesis of new enzymes based on the lactate dehydrogenase framework

1 reference

https://pubmed.ncbi.nlm.nih.gov/8528073

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Converting trypsin to chymotrypsin: residue 172 is a substrate specificity determinant

1 reference

https://pubmed.ncbi.nlm.nih.gov/8528073

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A designed peptide ligase for total synthesis of ribonuclease A with unnatural catalytic residues

1 reference

https://pubmed.ncbi.nlm.nih.gov/8528073

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1002/PRO.5560040910

1 reference

Europe PubMed Central

8 November 2017

1 reference

Europe PubMed Central

8 November 2017

1 reference

Europe PubMed Central

8 November 2017

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