(Q42863806)

8 November 2017

title

Identification of 2-oxo-N-(phenylmethyl)-4-imidazolidinecarboxamide antagonists of the P2X(7) receptor (English)

1 reference

8 November 2017

Identification of 2-oxo-N-(phenylmethyl)-4-imidazolidinecarboxamide antagonists of the P2X7 receptor (English)

1 reference

https://api.crossref.org/works/10.1016/J.BMCL.2010.09.101

30 July 2024

author name string

Lee Abberley

1

1 reference

8 November 2017

Aude Bebius

2

1 reference

8 November 2017

Andy Billinton

4

1 reference

8 November 2017

Elena Fonfria

7

1 reference

8 November 2017

Sadhana Patel

12

1 reference

8 November 2017

Tiziana Scoccitti

14

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8 November 2017

Beverley Smith

15

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8 November 2017

Paul J. Beswick

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20934331

30 July 2024

Katharine L. Collis

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20934331

30 July 2024

David K. Dean

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20934331

30 July 2024

Robert J. Gleave

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20934331

30 July 2024

Stephen J. Medhurst

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20934331

30 July 2024

Anton D. Michel

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20934331

30 July 2024

Andrew P. Moses

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20934331

30 July 2024

Shilina A. Roman

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20934331

30 July 2024

Jon G. A. Steadman

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20934331

30 July 2024

Daryl S. Walter

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20934331

30 July 2024

language of work or name

English

0 references

publication date

22 September 2010

1 reference

full work available at URL

8 November 2017

https://api.elsevier.com/content/article/PII:S0960894X10014101?httpAccept=text/xml

1 reference

https://api.crossref.org/works/10.1016/J.BMCL.2010.09.101

https://api.elsevier.com/content/article/PII:S0960894X10014101?httpAccept=text/plain

30 July 2024

1 reference

https://api.crossref.org/works/10.1016/J.BMCL.2010.09.101

Bioorganic & Medicinal Chemistry Letters

30 July 2024

published in

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8 November 2017

volume

20

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8 November 2017

issue

22

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8 November 2017

page(s)

6370-6374

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Tissue distribution of the P2X7 receptor

8 November 2017

cites work

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Extracellular ATP induces a large nonselective conductance in macrophage plasma membranes

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The P2X7 receptor: a key player in IL-1 processing and release

30 July 2024

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Purinergic signalling in neuron-glia interactions

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Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain

30 July 2024

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A-740003 [N-(1-{[(cyanoimino)(5-quinolinylamino) methyl]amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide], a novel and selective P2X7 receptor antagonist, dose-dependently reduces neuropathic pain in the rat

30 July 2024

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Characterization of N-(adamantan-1-ylmethyl)-5-[(3R-amino-pyrrolidin-1-yl)methyl]-2-chloro-benzamide, a P2X7 antagonist in animal models of pain and inflammation

30 July 2024

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Discovery and biological evaluation of novel cyanoguanidine P2X(7) antagonists with analgesic activity in a rat model of neuropathic pain

30 July 2024

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Structure-activity relationship studies on a series of novel, substituted 1-benzyl-5-phenyltetrazole P2X7 antagonists

30 July 2024

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Selective P2X(7) receptor antagonists for chronic inflammation and pain

30 July 2024

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The P2X7receptor as a therapeutic target

30 July 2024

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Synthesis and structure-activity relationships of a series of (1H-pyrazol-4-yl)acetamide antagonists of the P2X7 receptor

30 July 2024

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Structure-activity relationships and in vivo activity of (1H-pyrazol-4-yl)acetamide antagonists of the P2X(7) receptor

30 July 2024

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Discovery and structure-activity relationships of a series of pyroglutamic acid amide antagonists of the P2X7 receptor

30 July 2024

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Ligand efficiency indices for effective drug discovery

30 July 2024

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The influence of drug-like concepts on decision-making in medicinal chemistry

30 July 2024

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Rapid assessment of a novel series of selective CB(2) agonists using parallel synthesis protocols: A Lipophilic Efficiency (LipE) analysis

30 July 2024

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Utility of metabolic stability screening: comparison of in vitro and in vivo clearance

30 July 2024

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Studies on angiotensin converting enzyme inhibitors. 4. Synthesis and angiotensin converting enzyme inhibitory activities of 3-acyl-1-alkyl-2-oxoimidazolidine-4-carboxylic acid derivatives

30 July 2024

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Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics

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Structure-brain exposure relationships

30 July 2024

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Evaluation of the MDR-MDCK cell line as a permeability screen for the blood-brain barrier.

30 July 2024

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Evaluation of various dissolution media for predicting in vivo performance of class I and II drugs

30 July 2024

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An animal model of chronic inflammatory pain: pharmacological and temporal differentiation from acute models

30 July 2024

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P2X7 receptors in the nervous system

30 July 2024

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30 July 2024

Identifiers

1 reference

8 November 2017

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