(Q42882505)

9 November 2017

Fragment-based screening by biochemical assays: Systematic feasibility studies with trypsin and MMP12. (English)

1 reference

9 November 2017

Andreas Boettcher

1

1 reference

9 November 2017

Simon Ruedisser

2

1 reference

9 November 2017

Paulus Erbel

3

1 reference

9 November 2017

Daniela Vinzenz

4

1 reference

9 November 2017

Nikolaus Schiering

5

1 reference

9 November 2017

Ulrich Hassiepen

6

1 reference

9 November 2017

Pascal Rigollier

7

1 reference

9 November 2017

Lorenz M Mayr

8

1 reference

9 November 2017

Julian Woelcke

9

1 reference

9 November 2017

20 September 2010

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Journal of Biomolecular Screening

9 November 2017

1 reference

9 November 2017

15

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9 November 2017

1029-1041

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9 November 2017

9

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Fragment-based lead discovery

9 November 2017

1 reference

https://api.crossref.org/works/10.1177%2F1087057110380455

A decade of fragment-based drug design: strategic advances and lessons learned

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110380455

Fragment-based drug discovery: what has it achieved so far?

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110380455

Transforming fragments into candidates: small becomes big in medicinal chemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110380455

A ‘Rule of Three’ for fragment-based lead discovery?

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110380455

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110380455

Fragment screening by biochemical assay.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110380455

Integration of fragment screening and library design

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110380455

Molecular complexity and its impact on the probability of finding leads for drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110380455

Pursuing the leadlikeness concept in pharmaceutical research.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110380455

Fragment-based approach to drug lead discovery: overview and advances in various techniques

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110380455

Protein NMR-based screening in drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110380455

Practical aspects of NMR-based fragment discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110380455

SPR-based fragment screening: advantages and applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110380455

Fragment-based screening using surface plasmon resonance technology

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110380455

Label-free primary screening and affinity ranking of fragment libraries using parallel analysis of protein panels

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110380455

A new strategy for improved secondary screening and lead optimization using high-resolution SPR characterization of compound-target interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110380455

Fragment based drug discovery using fluorescence correlation: spectroscopy techniques: challenges and solutions

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110380455

Fragment-based identification of Hsp90 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110380455

A family of phosphodiesterase inhibitors discovered by cocrystallography and scaffold-based drug design

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110380455

Structure-based design of protein tyrosine phosphatase-1B inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110380455

Fragment-based discovery of BACE1 inhibitors using functional assays

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110380455

An integrated approach to fragment-based lead generation: philosophy, strategy and case studies from AstraZeneca's drug discovery programmes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110380455

Identification of selective, nonpeptidic nitrile inhibitors of cathepsin s using the substrate activity screening method

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110380455

Design and synthesis of novel inhibitors of gelatinase B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110380455

PRO_SELECT: combining structure-based drug design and array-based chemistry for rapid lead discovery. 2. The development of a series of highly potent and selective factor Xa inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110380455

NMR methods in fragment screening: theory and a comparison with other biophysical techniques

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110380455

Fragment-based activity space: smaller is better

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110380455

A fluorescence lifetime-based assay for protease inhibitor profiling on human kallikrein 7.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110380455

Library design for fragment based screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110380455

Stability of screening compounds in wet DMSO.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110380455

Identification of MMP-12 Inhibitors by Using Biosensor-Based Screening of a Fragment Library

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110380455

21 January 2018

Identifiers

DOI

10.1177/1087057110380455

1 reference

9 November 2017

1 reference