(Q42905427)

English

A Simple Liquid Chromatography-Tandem Mass Spectrometry Method to Determine Relative Plasma Exposures of Drug Metabolites across Species for Metabolite Safety Assessments

scientific article published on September 16, 2010

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

10 November 2017

A simple liquid chromatography-tandem mass spectrometry method to determine relative plasma exposures of drug metabolites across species for metabolite safety assessments (English)

1 reference

Europe PubMed Central

PubMed publication ID

10 November 2017

A Simple Liquid Chromatography-Tandem Mass Spectrometry Method to Determine Relative Plasma Exposures of Drug Metabolites across Species for Metabolite Safety Assessments (English)

1 reference

10.1124/DMD.110.034637

https://api.crossref.org/works/10.1124/DMD.110.034637

14 July 2024

exposure assessment

1 reference

based on heuristic

inferred from title

liquid chromatography-tandem mass spectrometry

1 reference

based on heuristic

inferred from title

author name string

Hongying Gao

1

1 reference

Europe PubMed Central

PubMed publication ID

10 November 2017

Shibing Deng

2

1 reference

Europe PubMed Central

PubMed publication ID

10 November 2017

R. Scott Obach

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20847138

14 July 2024

language of work or name

1 reference

National Center for Biotechnology Information

PubMed publication ID

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=20847138

14 July 2024

publication date

16 September 2010

1 reference

Europe PubMed Central

PubMed publication ID

10 November 2017

full work available at URL

http://intl-dmd.aspetjournals.org/cgi/content/abstract/38/12/2147

online access status

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20847138

14 July 2024

https://syndication.highwire.org/content/doi/10.1124/dmd.110.034637

1 reference

10.1124/DMD.110.034637

https://api.crossref.org/works/10.1124/DMD.110.034637

14 July 2024

Drug Metabolism and Disposition

1 reference

Europe PubMed Central

PubMed publication ID

10 November 2017

38

1 reference

Europe PubMed Central

PubMed publication ID

10 November 2017

12

1 reference

Europe PubMed Central

PubMed publication ID

10 November 2017

2147-2156

1 reference

Europe PubMed Central

PubMed publication ID

10 November 2017

Interpretation and considerations on the safety evaluation of human drug metabolites

1

1 reference

10.1124/DMD.110.034637

https://api.crossref.org/works/10.1124/DMD.110.034637

14 July 2024

Drug metabolites in safety testing

2

1 reference

10.1124/DMD.110.034637

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14 July 2024

A regulatory perspective on issues and approaches in characterizing human metabolites

3

1 reference

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Metabolites in safety testing: "MIST" for the clinical pharmacologist

4

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Method for rapid metabolite profiling of drug candidates in fresh hepatocytes using liquid chromatography coupled with a hybrid quadrupole linear ion trap

5

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Performance of columns packed with the new shell particles, Kinetex-C18.

6

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Product ion scanning using a Q‐q‐Qlinear ion trap (Q TRAPTM) mass spectrometer

7

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Determination of mean valproic acid serum level by assay of a single pooled sample

8

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14 July 2024

Drug metabolites in safety testing

9

1 reference

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Plasma-pooling methods to increase throughput for in vivo pharmacokinetic screening

10

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14 July 2024

Safety assessment of drug metabolites: Characterization of chemically stable metabolites

11

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Monitoring phospholipids for assessment of ion enhancement and ion suppression in ESI and APCI LC/MS/MS for chlorpheniramine in human plasma and the importance of multiple source matrix effect evaluations

12

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Which human metabolites have we MIST? Retrospective analysis, practical aspects, and perspectives for metabolite identification and quantification in pharmaceutical development.

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Simultaneously quantifying parent drugs and screening for metabolites in plasma pharmacokinetic samples using selected reaction monitoring information-dependent acquisition on a QTrap instrument

14

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Liquid chromatography-mass spectrometry/mass spectrometry method development for drug metabolism studies: Examining lipid matrix ionization effects in plasma

15

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Metabolites in safety testing

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A novel approach to perform metabolite screening during the quantitative LC-MS/MS analyses of in vitro metabolic stability samples using a hybrid triple-quadrupole linear ion trap mass spectrometer

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Seeing through the mist: abundance versus percentage. Commentary on metabolites in safety testing

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Metabolites and safety: What are the concerns, and how should we address them?

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Identification of 3,N4-propanodeoxycytidine 5'-monophosphate formed by the reaction of acrolein with deoxycytidine 5'-monophosphate

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Obtaining exposures of metabolites in preclinical species through plasma pooling and quantitative NMR: addressing metabolites in safety testing (MIST) guidance without using radiolabeled compounds and chemically synthesized metabolite standards.

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A holistic strategy for characterizing the safety of metabolites through drug discovery and development

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Use of a quadrupole linear ion trap mass spectrometer in metabolite identification and bioanalysis

24

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Rapid screening and characterization of drug metabolites using a multiple ion monitoring-dependent MS/MS acquisition method on a hybrid triple quadrupole-linear ion trap mass spectrometer

25

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LC-MS/MS-based approach for obtaining exposure estimates of metabolites in early clinical trials using radioactive metabolites as reference standards

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Identifiers

10.1124/DMD.110.034637

1 reference

Europe PubMed Central

PubMed publication ID

10 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

10 November 2017

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