(Q42909224)

English

Platelet alpha IIb-beta 3 integrin engagement induces the tyrosine phosphorylation of Cbl and its association with phosphoinositide 3-kinase and Syk.

scientific article published on November 2000

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11042121%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

Platelet alpha IIb-beta 3 integrin engagement induces the tyrosine phosphorylation of Cbl and its association with phosphoinositide 3-kinase and Syk (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11042121%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

phosphorylation

1 reference

based on heuristic

inferred from title

Christilla Bachelot-Loza

3

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11042121%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

author name string

A Saci

1

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11042121%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

F Rendu

2

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11042121%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

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1 November 2000

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11042121%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

Biochemical Journal

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11042121%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

351 Pt 3

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11042121%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

669-676

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11042121%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

c-Cbl localizes to actin lamellae and regulates lamellipodia formation and cell morphology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221406

27 May 2018

SYK is upstream of phosphoinositide 3-kinase in B cell receptor signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221406

27 May 2018

Integrin cytoplasmic tyrosine motif is required for outside-in alphaIIbbeta3 signalling and platelet function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221406

27 May 2018

The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221406

27 May 2018

Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221406

27 May 2018

Cbl-mediated negative regulation of the Syk tyrosine kinase. A critical role for Cbl phosphotyrosine-binding domain binding to Syk phosphotyrosine 323

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221406

27 May 2018

Cbl: complex formation and functional implications

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221406

27 May 2018

A beta 1 integrin signaling pathway involving Src-family kinases, Cbl and PI-3 kinase is required for macrophage spreading and migration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221406

27 May 2018

The c-Cbl oncoprotein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221406

27 May 2018

Oncogenic forms of Cbl abrogate the anchorage requirement but not the growth factor requirement for proliferation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221406

27 May 2018

A type II phosphoinositide 3-kinase is stimulated via activated integrin in platelets. A source of phosphatidylinositol 3-phosphate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221406

27 May 2018

The Cbl protooncogene product: from an enigmatic oncogene to center stage of signal transduction.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221406

27 May 2018

Integrin signaling: the platelet paradigm

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221406

27 May 2018

c-Cbl is tyrosine-phosphorylated by interleukin-4 and enhances mitogenic and survival signals of interleukin-4 receptor by linking with the phosphatidylinositol 3'-kinase pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221406

27 May 2018

Differential signaling after beta1 integrin ligation is mediated through binding of CRKL to p120(CBL) and p110(HEF1)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221406

27 May 2018

Platelet activation and signal transduction by convulxin, a C-type lectin from Crotalus durissus terrificus (tropical rattlesnake) venom via the p62/GPVI collagen receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221406

27 May 2018

Molecular mechanisms of platelet adhesion and activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221406

27 May 2018

The proto-oncogene product p120(cbl) links c-Src and phosphatidylinositol 3'-kinase to the integrin signaling pathway.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221406

27 May 2018

Tyrosine phosphorylation of the product of the c-cbl protooncogene is [corrected] induced after integrin stimulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221406

27 May 2018

p120c-cbl is present in human blood platelets and is differentially involved in signaling by thrombopoietin and thrombin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221406

27 May 2018

Structural and functional diversity of phosphoinositide 3-kinases.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221406

27 May 2018

Outside-in integrin signal transduction. Alpha IIb beta 3-(GP IIb IIIa) tyrosine phosphorylation induced by platelet aggregation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221406

27 May 2018

Post-receptor events associated with thrombin-induced platelet activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221406

27 May 2018

Phosphoinositide 3-kinase inhibition spares actin assembly in activating platelets but reverses platelet aggregation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221406

27 May 2018

Integrins and signal transduction pathways: the road taken

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221406

27 May 2018

Anti-GPIIb/IIIa antibodies: powerful tools to investigate function and regulation of an integrin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221406

27 May 2018

Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221406

27 May 2018

v-cbl, an oncogene from a dual-recombinant murine retrovirus that induces early B-lineage lymphomas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221406

27 May 2018

The sequences of the human and mouse c-cbl proto-oncogenes show v-cbl was generated by a large truncation encompassing a proline-rich domain and a leucine zipper-like motif

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221406

27 May 2018

Tyrosine phosphorylation and association of FcgammaRII and p72(Syk) are not limited to the FcgammaRII signalling pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/11042121

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of platelet glycoprotein IIb-IIIa (alpha IIb-beta 3 integrin) in thrombin-induced synthesis of phosphatidylinositol 3',4'-bisphosphate

1 reference

https://pubmed.ncbi.nlm.nih.gov/11042121

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adhesion receptor activation of phosphatidylinositol 3-kinase. von Willebrand factor stimulates the cytoskeletal association and activation of phosphatidylinositol 3-kinase and pp60c-src in human platelets

1 reference

https://pubmed.ncbi.nlm.nih.gov/11042121

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of the protein tyrosine kinase pp72syk by platelet agonists and the integrin alpha IIb beta 3

1 reference

https://pubmed.ncbi.nlm.nih.gov/11042121

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphoinositide 3-kinase gamma and p85/phosphoinositide 3-kinase in platelets. Relative activation by thrombin receptor or beta-phorbol myristate acetate and roles in promoting the ligand-binding function of alphaIIbbeta3 integrin

1 reference

https://pubmed.ncbi.nlm.nih.gov/11042121

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of Fc gamma RIIA gene polymorphism in human platelet activation by monoclonal antibodies

1 reference

https://pubmed.ncbi.nlm.nih.gov/11042121

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The alpha2beta1 integrin is a necessary co-receptor for collagen-induced activation of Syk and the subsequent phosphorylation of phospholipase Cgamma2 in platelets

1 reference

https://pubmed.ncbi.nlm.nih.gov/11042121

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

D3 phosphoinositides and outside-in integrin signaling by glycoprotein IIb-IIIa mediate platelet actin assembly and filopodial extension induced by phorbol 12-myristate 13-acetate

1 reference

https://pubmed.ncbi.nlm.nih.gov/11042121

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct T cell activation by chimeric single chain Fv-Syk promotes Syk-Cbl association and Cbl phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/11042121

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The product of the proto-oncogene c-cbl: a negative regulator of the Syk tyrosine kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/11042121

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Negative regulation of mitogen-activated protein kinase activation by integrin alphaIIbbeta3 in platelets

1 reference

https://pubmed.ncbi.nlm.nih.gov/11042121

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glycoprotein Ib-von Willebrand factor interactions activate tyrosine kinases in human platelets

1 reference

https://pubmed.ncbi.nlm.nih.gov/11042121

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

c-Cbl: a regulator of T cell receptor-mediated signalling

1 reference

https://pubmed.ncbi.nlm.nih.gov/11042121

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a novel integrin signaling pathway involving the kinase Syk and the guanine nucleotide exchange factor Vav1

1 reference

https://pubmed.ncbi.nlm.nih.gov/11042121

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fc receptor-mediated platelet activation is dependent on phosphatidylinositol 3-kinase activation and involves p120(Cbl)

1 reference

https://pubmed.ncbi.nlm.nih.gov/11042121

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphoinositide 3-kinase and integrin signalling are involved in activation of Bruton tyrosine kinase in thrombin-stimulated platelets

1 reference

https://pubmed.ncbi.nlm.nih.gov/11042121

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic and pharmacological analyses of Syk function in alphaIIbbeta3 signaling in platelets

1 reference

https://pubmed.ncbi.nlm.nih.gov/11042121

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective association of the tyrosine kinases Src, Fyn, and Lyn with integrin-rich actin cytoskeletons of activated, nonaggregated platelets

1 reference

https://pubmed.ncbi.nlm.nih.gov/11042121

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1042/0264-6021:3510669

1 reference

Europe PubMed Central

PMC publication ID

10 November 2017

10.1042/BJ3510669

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11042121%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11042121%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11042121%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

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