(Q42991440)

English

The role of ATP citrate-lyase in the metabolic regulation of plasma lipids. Hypolipidaemic effects of SB-204990, a lactone prodrug of the potent ATP citrate-lyase inhibitor SB-201076.

scientific article published on August 1998

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

The role of ATP citrate-lyase in the metabolic regulation of plasma lipids. Hypolipidaemic effects of SB-204990, a lactone prodrug of the potent ATP citrate-lyase inhibitor SB-201076. (English)

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

0 references

author name string

Pearce NJ

1

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

Yates JW

2

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

Berkhout TA

3

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

Jackson B

4

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

Tew D

5

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

Boyd H

6

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

Camilleri P

7

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

Sweeney P

8

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

Gribble AD

9

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

Shaw A

10

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

Groot PH

11

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

language of work or name

0 references

publication date

1 August 1998

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

Biochemical Journal

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

334 ( Pt 1)

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

113-119

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

Hypolipidaemic properties of a potent and bioavailable alkylsulphinyl-diphenylimidazole ACAT inhibitor (RP 73163) in animals fed diets low in cholesterol

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219669

26 May 2018

More direct evidence for a malonyl-CoA-carnitine palmitoyltransferase I interaction as a key event in pancreatic beta-cell signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219669

26 May 2018

Regulatory role for hepatic low density lipoprotein receptors in vivo in the dog

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219669

26 May 2018

The use of a non-ionic detergent (Triton WR 1339) to determine rates of triglyceride entry into the circulation of the rat under different physiological conditions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219669

26 May 2018

Fatty acid synthesis in adipose tissue incubated in tritiated water

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219669

26 May 2018

Intrahepatic assembly of very low density lipoproteins. Varied synthetic response of individual apolipoproteins to fasting.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219669

26 May 2018

Contributions of fatty acid and sterol synthesis to triglyceride and cholesterol secretion by the perfused rat liver in genetic hyperlipemia and obesity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219669

26 May 2018

CS-514, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase: tissue-selective inhibition of sterol synthesis and hypolipidemic effect on various animal species

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219669

26 May 2018

Secretion and storage of newly synthesized hepatic triacylglycerol fatty acids in vivo in different nutritional states and in diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219669

26 May 2018

Cholesterol is required for secretion of very-low-density lipoprotein by rat liver

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219669

26 May 2018

Cholesterol is required for the secretion of the very-low-density lipoprotein: in vivo studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219669

26 May 2018

Rat ATP citrate-lyase. Molecular cloning and sequence analysis of a full-length cDNA and mRNA abundance as a function of diet, organ, and age

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219669

26 May 2018

Assembly and secretion of hepatic very-low-density lipoprotein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219669

26 May 2018

The effect of (-)-hydroxycitrate on the activity of the low-density-lipoprotein receptor and 3-hydroxy-3-methylglutaryl-CoA reductase levels in the human hepatoma cell line Hep G2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219669

26 May 2018

Lowering of plasma cholesterol levels in animals by lovastatin and simvastatin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219669

26 May 2018

The discovery and development of HMG-CoA reductase inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219669

26 May 2018

Cloning and expression of a human ATP-citrate lyase cDNA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219669

26 May 2018

A possible role for malonyl-CoA in the regulation of hepatic fatty acid oxidation and ketogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219669

26 May 2018

5-(Tetradecyloxy)-2-furancarboxylic acid and related hypolipidemic fatty acid-like alkyloxyarylcarboxylic acids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219669

26 May 2018

Metabolic regulation as a control for lipid disorders. I. Influence of (—)-hydroxycitrate on experimentally induced obesity in the rodent

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219669

26 May 2018

Acute effects in vivo of anti-insulin serum on rates of fatty acid synthesis and activities of acetyl-coenzyme A carboxylase and pyruvate dehydrogenase in liver and epididymal adipose tissue of fed rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219669

26 May 2018

Regulation of cholesterol synthesis in the liver and mammary gland of the lactating rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219669

16 August 2018

Tricarballylate and hydroxycitrate: substrate and inhibitor of ATP: citrate oxaloacetate lyase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219669

16 August 2018

ATP-citrate lyase from rat liver. Characterisation of the citryl-enzyme complexes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219669

16 August 2018

Inhibition of cholesterol synthesis by (-)-hydroxycitrate in perfused rat liver. Evidence for an extramitochondrial mevalonate synthesis from acetyl coenzyme A

1 reference

https://pubmed.ncbi.nlm.nih.gov/9693110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

3-β-Hydroxysterol synthesis by the liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/9693110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of triglyceride-lowering effect of an HMG-CoA reductase inhibitor in a hypertriglyceridemic animal model, the Zucker obese rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/9693110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ATP-citrate lyase as a target for hypolipidemic intervention. Design and synthesis of 2-substituted butanedioic acids as novel, potent inhibitors of the enzyme

1 reference

https://pubmed.ncbi.nlm.nih.gov/9693110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased hepatic production of very low density lipoproteins following activation of fatty acid oxidation by Ro 22-0654

1 reference

https://pubmed.ncbi.nlm.nih.gov/9693110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Measurement of rates of cholesterol synthesis using tritiated water

1 reference

https://pubmed.ncbi.nlm.nih.gov/9693110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of fatty acid synthesis decreases very low density lipoprotein secretion in the hamster

1 reference

https://pubmed.ncbi.nlm.nih.gov/9693110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of (—)-Hydroxycitrate on Fatty Acid Synthesis by Rat Liver in Vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/9693110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of lipogenesis in rat liver by (-)-hydroxycitrate

1 reference

https://pubmed.ncbi.nlm.nih.gov/9693110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

36 Hydroxycitrate

1 reference

https://pubmed.ncbi.nlm.nih.gov/9693110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hupolipidemic activity of (--)-hydroxycitrate

1 reference

https://pubmed.ncbi.nlm.nih.gov/9693110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interactions between fatty acid synthesis, oxidation, and esterification in the production of triglyceride-rich lipoproteins by the liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/9693110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of enzymes which interact with citrate by (--)hydroxycitrate and 1,2,3,-tricarboxybenzene

1 reference

https://pubmed.ncbi.nlm.nih.gov/9693110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SR-12813 lowers plasma cholesterol in beagle dogs by decreasing cholesterol biosynthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/9693110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1042/BJ3340113

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

ResearchGate publication ID

0 references

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