(Q43000484)

12 November 2017

Hormone-triggered conformational changes within the insulin-receptor ectodomain: requirement for transmembrane anchors (English)

1 reference

12 November 2017

transmembrane protein

0 references

1 reference

Flörke RR

1

1 reference

12 November 2017

Schnaith K

2

1 reference

12 November 2017

Passlack W

3

1 reference

12 November 2017

Wichert M

4

1 reference

12 November 2017

Kuehn L

5

1 reference

12 November 2017

Fabry M

6

1 reference

12 November 2017

Federwisch M

7

1 reference

12 November 2017

Reinauer H

8

1 reference

12 November 2017

language of work or name

English

0 references

publication date

1 November 2001

1 reference

12 November 2017

1 reference

12 November 2017

360

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12 November 2017

Pt 1

1 reference

12 November 2017

189-198

1 reference

Structure and function of the type 1 insulin-like growth factor receptor.

12 November 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222217

High affinity insulin binding by soluble insulin receptor extracellular domain fused to a leucine zipper

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222217

The insulin receptor: from protein sequence to structure.

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222217

Structural studies of the detergent-solubilized and vesicle-reconstituted insulin receptor

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222217

Structural analysis of receptor tyrosine kinases

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222217

Crystal structure of the first three domains of the type-1 insulin-like growth factor receptor

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222217

Signal transduction mechanism of insulin and insulin-like growth factor-1.

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222217

Conformational changes of the insulin receptor upon insulin binding and activation as monitored by fluorescence spectroscopy.

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222217

Fusion of insulin receptor ectodomains to immunoglobulin constant domains reproduces high-affinity insulin binding in vitro

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222217

The IRS-signalling system in insulin and cytokine action

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222217

Transmembrane signaling by an insulin receptor lacking a cytoplasmic beta-subunit domain

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222217

Optimizing transmembrane domain helicity accelerates insulin receptor internalization and lateral mobility

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222217

The insulin receptor: structure, function, and signaling

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222217

Transmembrane domain interactions are necessary for negative cooperativity of the insulin receptor

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222217

Mapping of an NH2-terminal ligand binding site of the insulin receptor by alanine scanning mutagenesis

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222217

The structural basis of insulin and insulin-like growth factor-I receptor binding and negative co-operativity, and its relevance to mitogenic versus metabolic signalling.

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222217

Signalling through the insulin receptor and the insulin-like growth factor-I receptor

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222217

Signaling-competent receptor chimeras allow mapping of major insulin receptor binding domain determinants

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222217

How do protein kinases discriminate between serine/threonine and tyrosine? Structural insights from the insulin receptor protein-tyrosine kinase.

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222217

On the tertiary structure of the extracellular domains of the epidermal growth factor and insulin receptors.

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222217

The insulin receptor. Structural basis for high affinity ligand binding

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222217

Anisotropy decay of fluorescence as an experimental approach to protein dynamics

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222217

Properties of the insulin receptor ectodomain

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222217

Properties of a human insulin receptor with a COOH-terminal truncation. I. Insulin binding, autophosphorylation, and endocytosis

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222217

Secretion of soluble functional insulin receptors by transfected NIH3T3 cells.

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222217

Signal transduction by receptors with tyrosine kinase activity

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222217

A model for the quaternary structure of human placental insulin receptor deduced from electron microscopy

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222217

Insulin receptor tyrosine kinase structure and function

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222217

Detection of a new hormone contact site within the insulin receptor ectodomain by the use of a novel photoreactive insulin

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222217

Structural organization of the human insulin receptor ectodomain.

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222217

Substitution of the insulin receptor transmembrane domain with the c-neu/erbB2 transmembrane domain constitutively activates the insulin receptor kinase in vitro

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222217

Identification of determinants that confer ligand specificity on the insulin receptor

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222217

Subnanosecond motions of tryptophan residues in proteins

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222217

Substitution of the insulin receptor transmembrane domain with that of glycophorin A inhibits insulin action.

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222217

Deletion of 343 amino acids from the carboxyl terminus of the beta-subunit of the insulin receptor inhibits insulin signaling

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222217

Single-molecule imaging of human insulin receptor ectodomain and its Fab complexes

16 August 2018

1 reference

12 December 2020

A model for insulin binding to the insulin receptor

1 reference

12 December 2020

Membrane topology of insulin receptors reconstituted into lipid vesicles

1 reference

12 December 2020

An irregularity in the transmembrane domain helix correlates with the rate of insulin receptor internalization

1 reference

12 December 2020

Transmembrane domain inversion blocks ER release and insulin receptor signaling

1 reference

12 December 2020

Role of the transmembrane domain and flanking amino acids in internalization and down-regulation of the insulin receptor

1 reference

12 December 2020

Analog binding properties of insulin receptor mutants. Identification of amino acids interacting with the COOH terminus of the B-chain of the insulin molecule

1 reference

12 December 2020

Quaternary structure of the insulin-insulin receptor complex

1 reference

12 December 2020

Specificity of insulin and insulin-like growth factor I receptors investigated using chimeric mini-receptors. Role of C-terminal of receptor alpha subunit

1 reference

12 December 2020

Ligand-induced conformational change in the minimized insulin receptor

1 reference

12 December 2020

The subunit structure of the high affinity insulin receptor. Evidence for a disulfide-linked receptor complex in fat cell and liver plasma membranes

1 reference

12 December 2020

Isolation of functional alpha beta heterodimers from the purified human placental alpha 2 beta 2 heterotetrameric insulin receptor complex. A structural basis for insulin binding heterogeneity

1 reference

12 December 2020

Isolation of a proteolytically derived domain of the insulin receptor containing the major site of cross-linking/binding

1 reference

12 December 2020

Truncation of the ectodomain of the human insulin receptor results in secretion of a soluble insulin binding protein from transfected CHO cells

1 reference

12 December 2020

Structural requirements for signal transduction of the insulin receptor

1 reference

12 December 2020

Differential insertion of insulin receptor complexes into Triton X-114 bilayer membranes. Evidence for a differential accessibility of the membrane-exposed receptor domain

1 reference

12 December 2020

10.1042/0264-6021:3600189

Identifiers

DOI

1 reference

12 November 2017

1 reference

12 November 2017

PubMed publication ID

11696007

1 reference