(Q43002523)

12 November 2017

Methyl pyruvate stimulates pancreatic beta-cells by a direct effect on KATP channels, and not as a mitochondrial substrate (English)

1 reference

12 November 2017

Martina Düfer

1

1 reference

12 November 2017

Peter Krippeit-Drews

2

1 reference

12 November 2017

Linas Buntinas

3

1 reference

12 November 2017

Detlef Siemen

4

1 reference

12 November 2017

Gisela Drews

5

1 reference

12 November 2017

language of work or name

English

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publication date

1 December 2002

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12 November 2017

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12 November 2017

368

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12 November 2017

Pt 3

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12 November 2017

817-825

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Methyl pyruvate initiates membrane depolarization and insulin release by metabolic factors other than ATP

12 November 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223048

Differential regulation of [Ca2+]i oscillations in mouse pancreatic islets by glucose, alpha-ketoisocaproic acid, glyceraldehyde and glycolytic intermediates

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223048

Contrasting effects of alloxan on islets and single mouse pancreatic beta-cells

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223048

Overexpression of monocarboxylate transporter and lactate dehydrogenase alters insulin secretory responses to pyruvate and lactate in beta cells

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223048

Ca2+-activated K channel of the BK-type in the inner mitochondrial membrane of a human glioma cell line

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223048

Defective pancreatic beta-cell glycolytic signaling in hepatocyte nuclear factor-1alpha-deficient mice

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223048

Direct effects of diazoxide on mitochondria in pancreatic B-cells and on isolated liver mitochondria

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223048

In vitro and in vivo insulinotropic action of methyl pyruvate.

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223048

Activation of stimulus-secretion coupling in pancreatic beta-cells by specific products of glucose metabolism. Evidence for privileged signaling by glycolysis.

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223048

Substrate-dependent changes in mitochondrial function, intracellular free calcium concentration and membrane channels in pancreatic beta-cells

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223048

Low lactate dehydrogenase and high mitochondrial glycerol phosphate dehydrogenase in pancreatic beta-cells. Potential role in nutrient sensing.

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223048

A new generation of Ca2+ indicators with greatly improved fluorescence properties

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223048

Dual effect of glucose on cytoplasmic Ca2+ in single pancreatic beta-cells

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223048

Effects of putative activators of K+ channels in mouse pancreatic beta-cells

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223048

Electrophysiology of the pancreatic beta-cell

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223048

ATP-sensitive K+ channel in the mitochondrial inner membrane

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223048

The stimulus-secretion coupling of glucose-induced insulin release. Effect of exogenous pyruvate on islet function

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223048

Inhibition of mitochondrial function affects cellular Ca2+ handling in pancreatic B-cells

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223048

Histochemical evidence for pathways insulin cells use to oxidize glycolysis-derived NADH.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223048

Identification and properties of a novel intracellular (mitochondrial) ATP-sensitive potassium channel in brain.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223048

Parallel oscillations of intracellular calcium activity and mitochondrial membrane potential in mouse pancreatic B-cells.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223048

Mitochondrial glutamate acts as a messenger in glucose-induced insulin exocytosis.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223048

Energetic requirement of carbachol-induced Ca2+ signaling in single mouse beta-cells

16 August 2018

1 reference

12 December 2020

The effect of oxamate on glycolysis in intact ascites tumor cells I. Kinetic evidence for a dual glycolytic system

1 reference

12 December 2020

Effects of alpha-ketocarboxylic acids and 4-pentenoic acid on insulin secretion from the perfused rat pancreas

1 reference

12 December 2020

Properties and calcium-dependent inactivation of calcium currents in cultured mouse pancreatic B-cells

1 reference

12 December 2020

Reconstitution and partial purification of the glibenclamide-sensitive, ATP-dependent K+ channel from rat liver and beef heart mitochondria

1 reference

12 December 2020

Dependence on NADH produced during glycolysis for beta-cell glucose signaling

1 reference

12 December 2020

Amperometric detection of quantal secretion from patch-clamped rat pancreatic beta-cells

1 reference

12 December 2020

Insulinotropic action of methyl pyruvate: secretory, cationic, and biosynthetic aspects

1 reference

12 December 2020

Insulinotropic action of methyl pyruvate: enzymatic and metabolic aspects

1 reference

12 December 2020

Influence of pyruvic acid methyl ester on rat pancreatic islets. Effects on insulin secretion, phosphoinositide hydrolysis, and sensitization of the beta cell

1 reference

12 December 2020

Role of NADH shuttle system in glucose-induced activation of mitochondrial metabolism and insulin secretion

1 reference

12 December 2020

Direct effects of tolbutamide on mitochondrial function, intracellular Ca2+ and exocytosis in pancreatic beta-cells

1 reference

12 December 2020

Identifiers

DOI

10.1042/BJ20020657

1 reference

12 November 2017

1 reference

12 November 2017

1 reference