(Q43002647)

English

Mechanism of action of interleukin-2 (IL-2)-Bax, an apoptosis-inducing chimaeric protein targeted against cells expressing the IL-2 receptor

scientific article published in February 2003

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

Mechanism of action of interleukin-2 (IL-2)-Bax, an apoptosis-inducing chimaeric protein targeted against cells expressing the IL-2 receptor (English)

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

author name string

Rami Aqeilan

1

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

Rotem Kedar

2

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

Ahmi Ben-Yehudah

3

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

Haya Lorberboum-Galski

4

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

language of work or name

0 references

publication date

1 February 2003

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

Biochemical Journal

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

370

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

Pt 1

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

129-140

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

Arsenic trioxide induces apoptosis in human T-cell leukemia virus type 1- and type 2-infected cells by a caspase-3-dependent mechanism involving Bcl-2 cleavage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223140

26 May 2018

Formation of nuclear Bax/p53 complexes is associated with chemotherapy induced apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223140

26 May 2018

Structure of Bax: coregulation of dimer formation and intracellular localization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223140

26 May 2018

Bax is a transcriptional target and mediator of c-myc-induced apoptosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223140

26 May 2018

Surfing the p53 network

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223140

26 May 2018

Caspases disrupt the nuclear-cytoplasmic barrier

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223140

26 May 2018

Cleavage of Bax enhances its cell death function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223140

26 May 2018

Susceptibility of HIV-1-TAT transfected cells to undergo apoptosis. Biochemical mechanisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223140

26 May 2018

Regulation of the p53 tumor suppressor protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223140

26 May 2018

Inhibition of caspase cascade by HTLV-I tax through induction of NF-kappaB nuclear translocation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223140

26 May 2018

Induction of Bcl-x(L) expression by human T-cell leukemia virus type 1 Tax through NF-kappaB in apoptosis-resistant T-cell transfectants with Tax.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223140

26 May 2018

BCL-2 family members and the mitochondria in apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223140

26 May 2018

p53 suppresses the activation of the Bcl-2 promoter by the Brn-3a POU family transcription factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223140

26 May 2018

Conformation of the Bax C-terminus regulates subcellular location and cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223140

26 May 2018

A link between cell cycle and cell death: Bax and Bcl-2 modulate Cdk2 activation during thymocyte apoptosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223140

26 May 2018

Nuclear translocation and increased expression of Bax and disturbance in cell cycle progression without prominent apoptosis induced by hyperthermia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223140

26 May 2018

Mitochondria and apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223140

26 May 2018

Caspases: enemies within

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223140

26 May 2018

Phosphorylation of p53: a novel pathway for p53 inactivation in human T-cell lymphotropic virus type 1-transformed cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223140

26 May 2018

BAX frameshift mutations in cell lines derived from human haemopoietic malignancies are associated with resistance to apoptosis and microsatellite instability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223140

26 May 2018

Bax directly induces release of cytochrome c from isolated mitochondria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223140

26 May 2018

Hematopoietic malignancies demonstrate loss-of-function mutations of BAX

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223140

26 May 2018

Inhibition of p53 transactivation function by the human T-cell lymphotropic virus type 1 Tax protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223140

26 May 2018

Heterodimerization-independent functions of cell death regulatory proteins Bax and Bcl-2 in yeast and mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223140

26 May 2018

Movement of Bax from the cytosol to mitochondria during apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223140

26 May 2018

Comparison of the ion channel characteristics of proapoptotic BAX and antiapoptotic BCL-2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223140

26 May 2018

The anti-apoptosis function of Bcl-2 can be genetically separated from its inhibitory effect on cell cycle entry

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223140

26 May 2018

Bcl-2 and Bax function independently to regulate cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223140

26 May 2018

Inhibition of Bax channel-forming activity by Bcl-2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223140

26 May 2018

Repression of bax gene expression by the HTLV-1 Tax protein: implications for suppression of apoptosis in virally infected cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223140

26 May 2018

Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223140

26 May 2018

The cell death inhibitor Bcl-2 and its homologues influence control of cell cycle entry

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223140

26 May 2018

Benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone (Z-VAD.FMK) inhibits apoptosis by blocking the processing of CPP32.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223140

26 May 2018

Stabilization of wild-type p53 in human T-lymphocytes transformed by HTLV-I.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223140

26 May 2018

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223140

26 May 2018

Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223140

26 May 2018

p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223140

26 May 2018

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223140

26 May 2018

Multiple Bcl-2 family members demonstrate selective dimerizations with Bax

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223140

26 May 2018

Cytotoxic activity of an interleukin 2-Pseudomonas exotoxin chimeric protein produced in Escherichia coli

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223140

26 May 2018

A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223140

26 May 2018

Suppression of interleukin-2 and interleukin-2 receptor expression in Jurkat cells stably expressing the human immunodeficiency virus Tat protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223140

26 May 2018

N-terminal cleavage of bax by calpain generates a potent proapoptotic 18-kDa fragment that promotes bcl-2-independent cytochrome C release and apoptotic cell death.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223140

16 August 2018

Phase I trial of a ligand fusion-protein (DAB389IL-2) in lymphomas expressing the receptor for interleukin-2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223140

16 August 2018

Radioimmunotherapy of interleukin-2R alpha-expressing adult T-cell leukemia with Yttrium-90-labeled anti-Tac.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223140

16 August 2018

DAB389IL2 diphtheria fusion toxin produces clinical responses in tumor stage cutaneous T cell lymphoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/12405905

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bcl-2 and Bax proteins are present in interphase nuclei of mammalian cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12405905

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial control of apoptosis: the role of cytochrome c

1 reference

https://pubmed.ncbi.nlm.nih.gov/12405905

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nuclear targeting of Bax during apoptosis in human colorectal cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12405905

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The use of antibodies against the IL-2 receptor in transplantation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12405905

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin 2-Bax: a novel prototype of human chimeric proteins for targeted therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/12405905

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural association of Bax with nuclear matrix and cytomatrix revealed by embedment-free immunogold electron microscopy

1 reference

https://pubmed.ncbi.nlm.nih.gov/12405905

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GnRH-Bik/Bax/Bak chimeric proteins target and kill adenocarcinoma cells; the general use of pro-apoptotic proteins of the Bcl-2 family as novel killing components of targeting chimeric proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/12405905

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A small-scale procedure for preparation of nuclear extracts that support efficient transcription and pre-mRNA splicing

1 reference

https://pubmed.ncbi.nlm.nih.gov/12405905

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-2-PE40 is cytotoxic for activated T lymphocytes expressing IL-2 receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/12405905

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gain-of-function p53 mutations enhance alteration of the T-cell receptor following X-irradiation, independently of the cell cycle and cell survival

1 reference

https://pubmed.ncbi.nlm.nih.gov/12405905

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1042/BJ20020958

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

ResearchGate publication ID

0 references

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