(Q43042024)

English

2'-deoxy-4'-azido nucleoside analogs are highly potent inhibitors of hepatitis C virus replication despite the lack of 2'-alpha-hydroxyl groups

scientific article published on 14 November 2007

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

12 November 2017

2'-deoxy-4'-azido nucleoside analogs are highly potent inhibitors of hepatitis C virus replication despite the lack of 2'-alpha-hydroxyl groups (English)

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Europe PubMed Central

PubMed publication ID

12 November 2017

Hepatitis C virus

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based on heuristic

inferred from title

author name string

Klaus Klumpp

1

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Europe PubMed Central

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12 November 2017

Genadiy Kalayanov

2

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12 November 2017

Han Ma

3

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12 November 2017

Sophie Le Pogam

4

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12 November 2017

Vincent Leveque

5

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12 November 2017

Wen-Rong Jiang

6

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12 November 2017

Nicole Inocencio

7

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12 November 2017

Anniek De Witte

8

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12 November 2017

Sonal Rajyaguru

9

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12 November 2017

Ezra Tai

10

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12 November 2017

Sushmita Chanda

11

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12 November 2017

Michael R Irwin

12

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12 November 2017

Christian Sund

13

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12 November 2017

Anna Winqist

14

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12 November 2017

Tatiana Maltseva

15

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12 November 2017

Staffan Eriksson

16

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12 November 2017

Elena Usova

17

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12 November 2017

Mark Smith

18

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12 November 2017

Andre Alker

19

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12 November 2017

Isabel Najera

20

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12 November 2017

Nick Cammack

21

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12 November 2017

Joseph A Martin

22

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12 November 2017

Nils Gunnar Johansson

23

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12 November 2017

David B Smith

24

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12 November 2017

language of work or name

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publication date

14 November 2007

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12 November 2017

Journal of Biological Chemistry

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12 November 2017

283

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12 November 2017

4

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12 November 2017

2167-2175

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12 November 2017

Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection

1 reference

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21 January 2018

Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial

1 reference

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21 January 2018

Baseline factors prognostic of sustained virological response in patients with HIV-hepatitis C virus co-infection

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21 January 2018

Diagnosis, management, and treatment of hepatitis C

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https://api.crossref.org/works/10.1074%2FJBC.M708929200

21 January 2018

Novel protease and polymerase inhibitors for the treatment of hepatitis C virus infection

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21 January 2018

The novel nucleoside analog R1479 (4'-azidocytidine) is a potent inhibitor of NS5B-dependent RNA synthesis and hepatitis C virus replication in cell culture

1 reference

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21 January 2018

Design, synthesis, and antiviral properties of 4'-substituted ribonucleosides as inhibitors of hepatitis C virus replication: the discovery of R1479.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708929200

21 January 2018

Application of the phosphoramidate ProTide approach to 4'-azidouridine confers sub-micromolar potency versus hepatitis C virus on an inactive nucleoside.

1 reference

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21 January 2018

Choosing the right sugar: how polymerases select a nucleotide substrate

1 reference

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21 January 2018

Structural Analysis of the Hepatitis C Virus RNA Polymerase in Complex with Ribonucleotides

1 reference

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21 January 2018

Expression of human mitochondrial thymidine kinase in Escherichia coli: correlation between the enzymatic activity of pyrimidine nucleoside analogues and their inhibitory effect on bacterial growth

1 reference

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21 January 2018

Cloning and characterization of full-length mouse thymidine kinase 2: the N-terminal sequence directs import of the precursor protein into mitochondria

1 reference

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21 January 2018

Structure and function of cellular deoxyribonucleoside kinases

1 reference

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21 January 2018

In vitro selected Con1 subgenomic replicons resistant to 2'-C-methyl-cytidine or to R1479 show lack of cross resistance

1 reference

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21 January 2018

Characterization of the metabolic activation of hepatitis C virus nucleoside inhibitor beta-D-2'-Deoxy-2'-fluoro-2'-C-methylcytidine (PSI-6130) and identification of a novel active 5'-triphosphate species

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708929200

21 January 2018

Crystal structures of B-DNA with incorporated 2'-deoxy-2'-fluoro-arabino-furanosyl thymines: implications of conformational preorganization for duplex stability

1 reference

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21 January 2018

Molecular structures of two new anti-HIV nucleoside analogs: 9-(2,3-dideoxy-2-fluoro-beta-D-threo-pentofuranosyl)adenine and 9-(2,3-dideoxy-2-fluoro-beta-D-threo-pentofuranosyl)hypoxanthine

1 reference

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21 January 2018

Recent progress in the development of inhibitors of the hepatitis C virus RNA-dependent RNA polymerase

1 reference

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21 January 2018

First example of phosphoramidate approach applied to a 4'-substituted purine nucleoside (4'-azidoadenosine): conversion of an inactive nucleoside to a submicromolar compound versus hepatitis C virus

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708929200

21 January 2018

Inhibitory Effect of 2'-Substituted Nucleosides on Hepatitis C Virus Replication Correlates with Metabolic Properties in Replicon Cells

1 reference

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21 January 2018

Determination of the DNA sugar pucker using 13C NMR spectroscopy

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708929200

21 January 2018

Expression and purification of untagged full-length HCV NS5B RNA-dependent RNA polymerase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708929200

21 January 2018

Canonical 3'-deoxyribonucleotides as a chain terminator for HCV NS5B RNA-dependent RNA polymerase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708929200

21 January 2018

A 7-deaza-adenosine analog is a potent and selective inhibitor of hepatitis C virus replication with excellent pharmacokinetic properties

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708929200

21 January 2018

Inhibition of influenza virus transcription by 2'-deoxy-2'-fluoroguanosine

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708929200

21 January 2018

Inhibition of the subgenomic hepatitis C virus replicon in huh-7 cells by 2'-deoxy-2'-fluorocytidine.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708929200

21 January 2018

Design, synthesis, and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methylcytidine, a potent inhibitor of hepatitis C virus replication

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708929200

21 January 2018

The importance of being ribose at the cleavage site in the Tetrahymena ribozyme reaction

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708929200

21 January 2018

Characterization of cell lines carrying self-replicating hepatitis C virus RNAs

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708929200

21 January 2018

Effects of ribavirin on red blood cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708929200

21 January 2018

Structure of human dCK suggests strategies to improve anticancer and antiviral therapy

1 reference

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21 January 2018

Identifiers

10.1074/JBC.M708929200

1 reference

Europe PubMed Central

PubMed publication ID

12 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

12 November 2017

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