(Q43059453)

20484629

13 November 2017

title

Tyk2/STAT3 signaling mediates beta-amyloid-induced neuronal cell death: implications in Alzheimer's disease (English)

1 reference

13 November 2017

0 references

1 reference

1

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15 May 2020

Zhenguo Wu

9

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15 May 2020

A K Fu

2

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15 May 2020

author name string

Fanny C F Ip

3

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15 May 2020

Ho-Keung Ng

4

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15 May 2020

Guylène Page

6

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15 May 2020

Jerry H Wang

7

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15 May 2020

Kwok-On Lai

8

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15 May 2020

Nancy Y Ip

10

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15 May 2020

Jacques Hugon

5

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15 May 2020

language of work or name

English

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publication date

1 May 2010

1 reference

20484629

13 November 2017

published in

Journal of Neuroscience

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15 May 2020

volume

30

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15 May 2020

issue

20

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15 May 2020

page(s)

6873-6881

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describes a project that uses

15 May 2020

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6632652/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Gp-41-mediated astrocyte inducible nitric oxide synthase mRNA expression: involvement of interleukin-1beta production by microglia

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Nitric oxide synthases: targets for therapeutic strategies in neurological diseases

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Proteolytic processing and cell biological functions of the amyloid precursor protein

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Roles of STAT3 defined by tissue-specific gene targeting

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Tyk2 plays a restricted role in IFN alpha signaling, although it is required for IL-12-mediated T cell function

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Progressive, age-related behavioral impairments in transgenic mice carrying both mutant amyloid precursor protein and presenilin-1 transgenes

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Generation of aggregated beta-amyloid in the rat hippocampus impairs synaptic transmission and plasticity and causes memory deficits

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Reelin in plaques of beta-amyloid precursor protein and presenilin-1 double-transgenic mice

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Cyclooxygenase (COX)-2 and cell cycle activity in a transgenic mouse model of Alzheimer's disease neuropathology.

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Activation of c-Jun N-terminal kinase and p38 in an Alzheimer's disease model is associated with amyloid deposition.

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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

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Akt/GSK3beta serine/threonine kinases: evidence for a signalling pathway mediated by familial Alzheimer's disease mutations

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Modulation of the JNK and p38 pathways by cdk5 protein kinase in a transgenic mouse model of Alzheimer's disease

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Cyclin-dependent kinase 5 phosphorylates signal transducer and activator of transcription 3 and regulates its transcriptional activity

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Glia and their cytokines in progression of neurodegeneration

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Activation of cytokine signaling through leukemia inhibitory factor receptor (LIFR)/gp130 attenuates ischemic brain injury in rats

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Current advances on different kinases involved in tau phosphorylation, and implications in Alzheimer's disease and tauopathies

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Circulating biomarkers of cognitive decline and dementia

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Differential role of Jak-STAT signaling in retinal degenerations

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Characterization of amyloid deposition in the APPswe/PS1dE9 mouse model of Alzheimer disease.

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Plaques, tangles, and memory loss in mouse models of neurodegeneration.

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Requirement of catalytically active Tyk2 and accessory signals for the induction of TRAIL mRNA by IFN-beta

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The GSK3 hypothesis of Alzheimer's disease

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Transcriptional regulation of beta-secretase by p25/cdk5 leads to enhanced amyloidogenic processing

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Neuroprotective and neurotoxic properties of glial cells in the pathogenesis of Alzheimer's disease

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Amyloid beta peptide toxicity in differentiated PC12 cells: calpain-calpastatin, caspase, and membrane damage

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Inflammatory aspects of Alzheimer disease and other neurodegenerative disorders

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Amyloid-beta causes memory impairment by disturbing the JAK2/STAT3 axis in hippocampal neurons.

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The role of neuroimmunomodulation in Alzheimer's disease.

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Processing of Alzheimer beta/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation

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Amyloid beta protein-induced neuronal cell death: neurotoxic properties of aggregated amyloid beta protein

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12 December 2020

Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation

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12 December 2020

A vector for expressing foreign genes in the brains and hearts of transgenic mice

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Hyperaccumulation of FAD-linked presenilin 1 variants in vivo.

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12 December 2020

Aggregated amyloid-beta protein induces cortical neuronal apoptosis and concomitant "apoptotic" pattern of gene induction.

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Amyloid beta-peptide stimulates nitric oxide production in astrocytes through an NFkappaB-dependent mechanism

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12 December 2020

10.1523/JNEUROSCI.0519-10.2010

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6632652&resulttype=core&format=json

15 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6632652&resulttype=core&format=json

15 May 2020

20484629

1 reference