(Q43064864)

English

Discovery of a potent, orally active 11beta-hydroxysteroid dehydrogenase type 1 inhibitor for clinical study: identification of (S)-2-((1S,2S,4R)-bicyclo[2.2.1]heptan-2-ylamino)-5-isopropyl-5-methylthiazol-4(5H)-one (AMG 221).

scientific article published in June 2010

Statements

Discovery of a potent, orally active 11beta-hydroxysteroid dehydrogenase type 1 inhibitor for clinical study: identification of (S)-2-((1S,2S,4R)-bicyclo[2.2.1]heptan-2-ylamino)-5-isopropyl-5-methylthiazol-4(5H)-one (AMG 221). (English)
Murielle M Véniant
Randall W Hungate
Michael D Bartberger
Renée Komorowski
Michelle M Chen
David J St Jean
Martin A Henriksson
Meredith Williams
Jerk Vallgårda
Christopher Fotsch

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