(Q43087622)

English

The endothelin receptor antagonist bosentan restores gut oxygen delivery and reverses intestinal mucosal acidosis in porcine endotoxin shock.

scientific article published in May 1998

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9659167%20AND%20SRC:MED&resulttype=core&format=json

13 November 2019

The endothelin receptor antagonist bosentan restores gut oxygen delivery and reverses intestinal mucosal acidosis in porcine endotoxin shock (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9659167%20AND%20SRC:MED&resulttype=core&format=json

13 November 2019

1 reference

based on heuristic

inferred from title

1

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9659167%20AND%20SRC:MED&resulttype=core&format=json

13 November 2019

6

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9659167%20AND%20SRC:MED&resulttype=core&format=json

13 November 2019

author name string

M Wanecek

2

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9659167%20AND%20SRC:MED&resulttype=core&format=json

13 November 2019

M Goiny

3

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9659167%20AND%20SRC:MED&resulttype=core&format=json

13 November 2019

E Weitzberg

4

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9659167%20AND%20SRC:MED&resulttype=core&format=json

13 November 2019

A Rudehill

5

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9659167%20AND%20SRC:MED&resulttype=core&format=json

13 November 2019

A Sollevi

7

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9659167%20AND%20SRC:MED&resulttype=core&format=json

13 November 2019

language of work or name

0 references

publication date

1 May 1998

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9659167%20AND%20SRC:MED&resulttype=core&format=json

13 November 2019

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9659167%20AND%20SRC:MED&resulttype=core&format=json

13 November 2019

42

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9659167%20AND%20SRC:MED&resulttype=core&format=json

13 November 2019

5

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9659167%20AND%20SRC:MED&resulttype=core&format=json

13 November 2019

696-702

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9659167%20AND%20SRC:MED&resulttype=core&format=json

13 November 2019

Pulmonary clearance of circulating endothelin-1 in dogs in vivo: exclusive role of ETB receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1727119

25 May 2018

Bosentan-improved cardiopulmonary vascular performance and increased plasma levels of endothelin-1 in porcine endotoxin shock

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1727119

25 May 2018

Determinants of intestinal barrier failure in critical illness

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1727119

25 May 2018

Splanchnic ischaemia/reperfusion and multiple organ failure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1727119

25 May 2018

Gut intramucosal pH and intraluminal PO2 in a porcine model of peritonitis or haemorrhage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1727119

25 May 2018

Pharmacological characterization of bosentan, a new potent orally active nonpeptide endothelin receptor antagonist

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1727119

25 May 2018

Splanchnic tonometry: a review of physiology, methodology, and clinical applications

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1727119

25 May 2018

Effects of bosentan (Ro 47-0203), an ETA-, ETB-receptor antagonist, on regional haemodynamic responses to endothelins in conscious rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1727119

25 May 2018

Dysregulation of the veno-arterial response in the superior mesenteric artery during endotoxic shock

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1727119

25 May 2018

Endotoxemia causes ileal mucosal acidosis in the absence of mucosal hypoxia in a normodynamic porcine model of septic shock

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1727119

25 May 2018

Nitric oxide: pathophysiological mechanisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1727119

25 May 2018

The Role of the l-arginine: Nitric Oxide Pathway in Circulatory Shock

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1727119

25 May 2018

Endothelin-1 and endotoxemia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1727119

25 May 2018

Splanchnic and total body oxygen consumption differences in septic and injured patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1727119

25 May 2018

Endotoxin promotes the translocation of bacteria from the gut.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1727119

25 May 2018

Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium-derived relaxing factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1727119

25 May 2018

Early detection of gastrointestinal mucosal ischemia in porcine E. coli sepsis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1727119

25 May 2018

Elevated plasma levels of endothelin in patients with sepsis syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1727119

25 May 2018

Gastrointestinal mucosal injury in experimental models of shock, trauma, and sepsis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1727119

25 May 2018

Elevated plasma endothelin-1 concentrations are associated with the severity of illness in patients with sepsis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1727119

25 May 2018

Gastric intramucosal pH as a therapeutic index of tissue oxygenation in critically ill patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1727119

25 May 2018

Gut failure and translocation following burn and sepsis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1727119

25 May 2018

Long-lasting vasoconstriction and efficient regional extraction of endothelin-1 in human splanchnic and renal tissues.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1727119

25 May 2018

Splanchnic homeostasis during endotoxin challenge in the pig as assessed by microdialysis and tonometry.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1727119

25 May 2018

Pathophysiologic role of endothelin-1 in renal function in rats with endotoxin shock.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1727119

25 May 2018

Maintenance of superior mesenteric arterial perfusion prevents increased intestinal mucosal permeability in endotoxic pigs.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1727119

25 May 2018

Endothelins mediate intestinal hypoperfusion during bacteremia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1727119

15 August 2018

The contrasting effects of dopamine and norepinephrine on systemic and splanchnic oxygen utilization in hyperdynamic sepsis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1727119

15 August 2018

Endothelin concentrations in experimental sepsis: profiles of big endothelin and endothelin 1-21 in lethal peritonitis in rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1727119

15 August 2018

Evidence for endothelin-1-mediated vasoconstriction in severe chronic heart failure.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1727119

15 August 2018

Biochemical and functional characterization of endothelin peptides with special reference to vascular effects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1727119

15 August 2018

Effect of different endothelin receptor antagonists and of the novel non-peptide antagonist Ro 46-2005 on endothelin levels in rat plasma

1 reference

https://pubmed.ncbi.nlm.nih.gov/9659167

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early gut ischemia in experimental fecal peritonitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/9659167

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intra-operative gut mucosal hypoperfusion is associated with increased post-operative complications and cost

1 reference

https://pubmed.ncbi.nlm.nih.gov/9659167

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasma levels of TNF-alpha, endothelin-1 and thrombomodulin in patients with sepsis

1 reference

https://pubmed.ncbi.nlm.nih.gov/9659167

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alternations in liver hemodynamics in an intact porcine model of endotoxin shock

1 reference

https://pubmed.ncbi.nlm.nih.gov/9659167

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gastric mucosal pH does not reflect changes in splanchnic blood flow after cardiac surgery

1 reference

https://pubmed.ncbi.nlm.nih.gov/9659167

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dobutamine-induced dissociation between changes in splanchnic blood flow and gastric intramucosal pH after cardiac surgery

1 reference

https://pubmed.ncbi.nlm.nih.gov/9659167

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alterations in mucosal morphology and permeability, but no bacterial or endotoxin translocation takes place after intestinal ischemia and early reperfusion in pigs

1 reference

https://pubmed.ncbi.nlm.nih.gov/9659167

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endothelin-1 causes accumulation of leukocytes in the pulmonary circulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/9659167

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of dopexamine on calculated low gastric intramucosal pH following valve replacement

1 reference

https://pubmed.ncbi.nlm.nih.gov/9659167

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endothelin-1 synthesis and receptor-mediated activity in porcine lymph vessels

1 reference

https://pubmed.ncbi.nlm.nih.gov/9659167

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endotoxic shock alters distribution of blood flow within the intestinal wall

1 reference

https://pubmed.ncbi.nlm.nih.gov/9659167

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heterogeneity of gut capillary transit times and impaired gut oxygen extraction in endotoxemic pigs

1 reference

https://pubmed.ncbi.nlm.nih.gov/9659167

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of Ro 47-0203 and PD155080 on the plasma kinetics, receptor binding and vascular effects of endothelin in the pig

1 reference

https://pubmed.ncbi.nlm.nih.gov/9659167

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cardiopulmonary dysfunction during porcine endotoxin shock is effectively counteracted by the endothelin receptor antagonist bosentan

1 reference

https://pubmed.ncbi.nlm.nih.gov/9659167

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reactivity of endothelin-1 on human and canine large veins compared with large arteries in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/9659167

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Splanchnic oxygen consumption in septic and hemorrhagic shock

1 reference

https://pubmed.ncbi.nlm.nih.gov/9659167

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sodium bicarbonate administration affects the diagnostic accuracy of gastrointestinal tonometry in acute mesenteric ischemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/9659167

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Assessment of splanchnic oxygenation by gastric tonometry in patients with acute circulatory failure

1 reference

https://pubmed.ncbi.nlm.nih.gov/9659167

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regional blood flow and oxygen transport in septic shock

1 reference

https://pubmed.ncbi.nlm.nih.gov/9659167

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1136/GUT.42.5.696

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9659167%20AND%20SRC:MED&resulttype=core&format=json

13 November 2019

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9659167%20AND%20SRC:MED&resulttype=core&format=json

13 November 2019

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9659167%20AND%20SRC:MED&resulttype=core&format=json

13 November 2019

ResearchGate publication ID

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