(Q43159277)

English

Reciprocal relationship between O6-methylguanine-DNA methyltransferase P140K expression level and chemoprotection of hematopoietic stem cells

scientific article published in August 2008

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

15 November 2017

Reciprocal relationship between O6-methylguanine-DNA methyltransferase P140K expression level and chemoprotection of hematopoietic stem cells (English)

1 reference

Europe PubMed Central

PMC publication ID

15 November 2017

author name string

Michael D Milsom

1

1 reference

Europe PubMed Central

PMC publication ID

15 November 2017

Moran Jerabek-Willemsen

2

1 reference

Europe PubMed Central

PMC publication ID

15 November 2017

Chad E Harris

3

1 reference

Europe PubMed Central

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15 November 2017

Axel Schambach

4

1 reference

Europe PubMed Central

PMC publication ID

15 November 2017

Emily Broun

5

1 reference

Europe PubMed Central

PMC publication ID

15 November 2017

Jeff Bailey

6

1 reference

Europe PubMed Central

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15 November 2017

Michael Jansen

7

1 reference

Europe PubMed Central

PMC publication ID

15 November 2017

David Schleimer

8

1 reference

Europe PubMed Central

PMC publication ID

15 November 2017

Kalpana Nattamai

9

1 reference

Europe PubMed Central

PMC publication ID

15 November 2017

Jamie Wilhelm

10

1 reference

Europe PubMed Central

PMC publication ID

15 November 2017

Amanda Watson

11

1 reference

Europe PubMed Central

PMC publication ID

15 November 2017

Hartmut Geiger

12

1 reference

Europe PubMed Central

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15 November 2017

Geoffrey P Margison

13

1 reference

Europe PubMed Central

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15 November 2017

Thomas Moritz

14

1 reference

Europe PubMed Central

PMC publication ID

15 November 2017

Christopher Baum

15

1 reference

Europe PubMed Central

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15 November 2017

Jürgen Thomale

16

1 reference

Europe PubMed Central

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15 November 2017

David A Williams

17

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Europe PubMed Central

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15 November 2017

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publication date

1 August 2008

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Europe PubMed Central

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15 November 2017

Cancer Research

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Europe PubMed Central

PMC publication ID

15 November 2017

68

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Europe PubMed Central

PMC publication ID

15 November 2017

15

1 reference

Europe PubMed Central

PMC publication ID

15 November 2017

6171-6180

1 reference

Europe PubMed Central

PMC publication ID

15 November 2017

Rac guanosine triphosphatases represent integrating molecular therapeutic targets for BCR-ABL-induced myeloproliferative disease

1 reference

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Insertional mutagenesis in gene therapy and stem cell biology

1 reference

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Stable differentiation and clonality of murine long-term hematopoiesis after extended reduced-intensity selection for MGMT P140K transgene expression

1 reference

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Vector design for expression of O6-methylguanine-DNA methyltransferase in hematopoietic cells

1 reference

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25 May 2018

Live and let die: in vivo selection of gene-modified hematopoietic stem cells via MGMT-mediated chemoprotection

1 reference

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Correlation between O6-methylguanine-DNA methyltransferase and survival in inoperable newly diagnosed glioblastoma patients treated with neoadjuvant temozolomide

1 reference

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25 May 2018

Cell-culture assays reveal the importance of retroviral vector design for insertional genotoxicity

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Lomeguatrib, a potent inhibitor of O6-alkylguanine-DNA-alkyltransferase: phase I safety, pharmacodynamic, and pharmacokinetic trial and evaluation in combination with temozolomide in patients with advanced solid tumors

1 reference

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25 May 2018

Phase I trial of temozolomide plus O6-benzylguanine for patients with recurrent or progressive malignant glioma

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25 May 2018

Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma

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LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1

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Myeloablation is not required to select and maintain expression of the drug-resistance gene, mutant MGMT, in primary and secondary recipients

1 reference

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High-level ectopic HOXB4 expression confers a profound in vivo competitive growth advantage on human cord blood CD34+ cells, but impairs lymphomyeloid differentiation

1 reference

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Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin

1 reference

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25 May 2018

Protection and in vivo selection of hematopoietic stem cells using temozolomide, O6-benzylguanine, and an alkyltransferase-expressing retroviral vector

1 reference

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25 May 2018

Phase I trial of carmustine plus O6-benzylguanine for patients with recurrent or progressive malignant glioma

1 reference

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25 May 2018

Direct reversal of DNA damage by mutant methyltransferase protein protects mice against dose-intensified chemotherapy and leads to in vivo selection of hematopoietic stem cells

1 reference

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25 May 2018

O6-alkylguanine-DNA alkyltransferase assay.

1 reference

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25 May 2018

O(6)-(4-bromothenyl)guanine improves the therapeutic index of temozolomide against A375M melanoma xenografts.

1 reference

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25 May 2018

Retroviral-mediated expression of the P140A, but not P140A/G156A, mutant form of O6-methylguanine DNA methyltransferase protects hematopoietic cells against O6-benzylguanine sensitization to chloroethylnitrosourea treatment.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4337843

25 May 2018

Isolation of human O6-alkylguanine-DNA alkyltransferase mutants highly resistant to inactivation by O6-benzylguanine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4337843

25 May 2018

Implication of localization of human DNA repair enzyme O6-methylguanine-DNA methyltransferase at active transcription sites in transcription-repair coupling of the mutagenic O6-methylguanine lesion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4337843

25 May 2018

Selection for G156A O6-methylguanine DNA methyltransferase gene-transduced hematopoietic progenitors and protection from lethality in mice treated with O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea.

1 reference

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25 May 2018

Plasmid-based transgenic mouse model for studying in vivo mutations

1 reference

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25 May 2018

Intensive 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU), NSC #4366650 and cryopreserved autologous marrow transplantation for refractory cancer. A phase I-II study

1 reference

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25 May 2018

O6 alkylguanine-DNA alkyltransferase activity in human myeloid cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4337843

25 May 2018

Intensive 1,3-bis (2-chloroethyl)-1-nitrosourea (BCNU) monochemotherapy and autologous marrow transplantation for malignant glioma

1 reference

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25 May 2018

Phase I trial of temozolomide (CCRG 81045: M&B 39831: NSC 362856)

1 reference

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25 May 2018

Modulation of mammalian O6-alkylguanine-DNA alkyltransferase in vivo by O6-benzylguanine and its effect on the sensitivity of a human glioma tumor to 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea.

1 reference

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3 July 2018

O6-methylguanine-DNA-methyltransferase (MGMT) gene therapy targeting haematopoietic stem cells: studies addressing safety issues

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Polyclonal chemoprotection against temozolomide in a large-animal model of drug resistance gene therapy

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15 August 2018

Hematoprotection and enrichment of transduced cells in vivo after gene transfer of MGMT(P140K) into hematopoietic stem cells

1 reference

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Down-regulation of DNA repair in human CD34(+) progenitor cells corresponds to increased drug sensitivity and apoptotic response

1 reference

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15 August 2018

Correlation of tumor O6 methylguanine-DNA methyltransferase levels with survival of malignant astrocytoma patients treated with bis-chloroethylnitrosourea: a Southwest Oncology Group study

1 reference

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15 August 2018

Equal potency of gammaretroviral and lentiviral SIN vectors for expression of O6-methylguanine-DNA methyltransferase in hematopoietic cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18676840

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutagenic potential of temozolomide in bone marrow cells in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/18676840

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alteration of arginine-128 to alanine abolishes the ability of human O6-alkylguanine-DNA alkyltransferase to repair methylated DNA but has no effect on its reaction with O6-benzylguanine

1 reference

https://pubmed.ncbi.nlm.nih.gov/18676840

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hematopoietic Cell Regulation by Rac1 and Rac2 Guanosine Triphosphatases

1 reference

https://pubmed.ncbi.nlm.nih.gov/18676840

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1158/0008-5472.CAN-08-0320

1 reference

Europe PubMed Central

PMC publication ID

15 November 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 November 2017

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