(Q43174214)

English

Design of new secreted phospholipase A2 inhibitors based on docking calculations by modifying the pharmacophore segments of the FPL67047XX inhibitor

scientific article published on 4 February 2010

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

15 November 2017

Design of new secreted phospholipase A2 inhibitors based on docking calculations by modifying the pharmacophore segments of the FPL67047XX inhibitor (English)

1 reference

Europe PubMed Central

PubMed publication ID

15 November 2017

Thomas Mavromoustakos

2

1 reference

Europe PubMed Central

PubMed publication ID

15 November 2017

author name string

Varnavas D Mouchlis

1

1 reference

Europe PubMed Central

PubMed publication ID

15 November 2017

George Kokotos

3

1 reference

Europe PubMed Central

PubMed publication ID

15 November 2017

publication date

4 February 2010

1 reference

Europe PubMed Central

PubMed publication ID

15 November 2017

Journal of Computer - Aided Molecular Design

1 reference

Europe PubMed Central

PubMed publication ID

15 November 2017

24

1 reference

Europe PubMed Central

PubMed publication ID

15 November 2017

2

1 reference

Europe PubMed Central

PubMed publication ID

15 November 2017

107-115

1 reference

Europe PubMed Central

PubMed publication ID

15 November 2017

https://scigraph.springernature.com/pub.10.1007/s10822-010-9319-7

0 references

The phospholipase A2 superfamily and its group numbering system

1 reference

https://api.crossref.org/works/10.1007%2FS10822-010-9319-7

21 January 2018

Platelet-activating factor acetylhydrolases in health and disease

1 reference

https://api.crossref.org/works/10.1007%2FS10822-010-9319-7

21 January 2018

Increasing molecular diversity of secreted phospholipases A(2) and their receptors and binding proteins

1 reference

https://api.crossref.org/works/10.1007%2FS10822-010-9319-7

21 January 2018

PhospholipaseA2: a key regulator of inflammatory signalling and a connector to fibrosis development in atherosclerosis

1 reference

https://api.crossref.org/works/10.1007%2FS10822-010-9319-7

21 January 2018

Roles of secretory phospholipases A(2) in inflammatory diseases and trauma

1 reference

https://api.crossref.org/works/10.1007%2FS10822-010-9319-7

21 January 2018

Studies on disease-modifying antirheumatic drugs: synthesis of novel quinoline and quinazoline derivatives and their anti-inflammatory effect

1 reference

https://api.crossref.org/works/10.1007%2FS10822-010-9319-7

21 January 2018

Bioisosterism: a useful strategy for molecular modification and drug design

1 reference

https://api.crossref.org/works/10.1007%2FS10822-010-9319-7

21 January 2018

Discovery of new non-phospholipid inhibitors of the secretory phospholipases A2

1 reference

https://pubmed.ncbi.nlm.nih.gov/20130961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Implications of a consensus recognition site for phosphatidylcholine separate from the active site in cobra venom phospholipases A2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20130961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Highly specific and broadly potent inhibitors of mammalian secreted phospholipases A2

1 reference

https://pubmed.ncbi.nlm.nih.gov/20130961

12 December 2020

based on heuristic

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Indole inhibitors of human nonpancreatic secretory phospholipase A2. 3. Indole-3-glyoxamides

1 reference

https://pubmed.ncbi.nlm.nih.gov/20130961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Future role for selective phospholipase A2 inhibitors in the prevention of atherosclerotic cardiovascular disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/20130961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Importance of group X-secreted phospholipase A2 in allergen-induced airway inflammation and remodeling in a mouse asthma model

1 reference

https://pubmed.ncbi.nlm.nih.gov/20130961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure and properties of a human non-pancreatic phospholipase A2

1 reference

https://pubmed.ncbi.nlm.nih.gov/20130961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structures of free and inhibited human secretory phospholipase A2 from inflammatory exudate

1 reference

https://pubmed.ncbi.nlm.nih.gov/20130961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A review of protein-small molecule docking methods

1 reference

https://pubmed.ncbi.nlm.nih.gov/20130961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Leukotrienes: Mediators of Immediate Hypersensitivity Reactions and Inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20130961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phospholipase A2 biochemistry

1 reference

https://pubmed.ncbi.nlm.nih.gov/20130961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phospholipase A2 inhibitors as potential anti-inflammatory agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/20130961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

D-Tyrosine as a chiral precusor to potent inhibitors of human nonpancreatic secretory phospholipase A2 (IIa) with antiinflammatory activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/20130961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biochemistry and physiology of mammalian secreted phospholipases A2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20130961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aromatic-aromatic interaction: a mechanism of protein structure stabilization

1 reference

https://pubmed.ncbi.nlm.nih.gov/20130961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potent inhibitors of secretory phospholipase A2: synthesis and inhibitory activities of indolizine and indene derivatives

1 reference

https://pubmed.ncbi.nlm.nih.gov/20130961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High-resolution X-ray crystallography reveals precise binding interactions between human nonpancreatic secreted phospholipase A2 and a highly potent inhibitor (FPL67047XX)

1 reference

https://pubmed.ncbi.nlm.nih.gov/20130961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The development of a simple empirical scoring function to estimate the binding constant for a protein-ligand complex of known three-dimensional structure

1 reference

https://pubmed.ncbi.nlm.nih.gov/20130961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pi-pi interactions: the geometry and energetics of phenylalanine-phenylalanine interactions in proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/20130961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Leukotrienes: a new class of mediators of immediate hypersensitivity reactions and inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20130961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis and phospholipase A2 inhibitory activity of thielocin B3 derivatives

1 reference

https://pubmed.ncbi.nlm.nih.gov/20130961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interfacial catalysis: the mechanism of phospholipase A2

1 reference

https://pubmed.ncbi.nlm.nih.gov/20130961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phospholipase A2 engineering. X-ray structural and functional evidence for the interaction of lysine-56 with substrates

1 reference

https://pubmed.ncbi.nlm.nih.gov/20130961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phospholipase A2 inhibitors as potential therapeutic agents for the treatment of inflammatory diseases.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20130961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cloning and recombinant expression of phospholipase A2 present in rheumatoid arthritic synovial fluid

1 reference

https://pubmed.ncbi.nlm.nih.gov/20130961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Design and synthesis of some substrate analogue inhibitors of phospholipase A2 and investigations by NMR and molecular modeling into the binding interactions in the enzyme-inhibitor complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/20130961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure of recombinant human rheumatoid arthritic synovial fluid phospholipase A2 at 2.2 A resolution

1 reference

https://pubmed.ncbi.nlm.nih.gov/20130961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure of an engineered porcine phospholipase A2 with enhanced activity at 2.1 A resolution. Comparison with the wild-type porcine and Crotalus atrox phospholipase A2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20130961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A molecular dynamics study of the three-dimensional model of human synovial fluid phospholipase A2--transition state mimic complexes

1 reference

https://pubmed.ncbi.nlm.nih.gov/20130961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Docking of hydrophobic ligands with interaction-based matching algorithms.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20130961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Estimates of the ab initio limit for pi-pi interactions: the benzene dimer

1 reference

https://pubmed.ncbi.nlm.nih.gov/20130961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evaluation of the FLEXX incremental construction algorithm for protein-ligand docking

1 reference

https://pubmed.ncbi.nlm.nih.gov/20130961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prostanoid biosynthesis and mechanisms of action

1 reference

https://pubmed.ncbi.nlm.nih.gov/20130961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bioisosterism: A Rational Approach in Drug Design

1 reference

https://pubmed.ncbi.nlm.nih.gov/20130961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phospholipase A2 inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/20130961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of drug binding affinities by comparative binding energy analysis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20130961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phospholipase A(2).

1 reference

https://pubmed.ncbi.nlm.nih.gov/20130961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interfacial kinetic and binding properties of the complete set of human and mouse groups I, II, V, X, and XII secreted phospholipases A2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20130961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Update on computer-aided drug design

1 reference

https://pubmed.ncbi.nlm.nih.gov/20130961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biology of secretory phospholipase A2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20130961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis and comparison of the antiinflammatory activity of manoalide and cacospongionolide B analogues

1 reference

https://pubmed.ncbi.nlm.nih.gov/20130961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purification and characterization of extracellular phospholipase A2 from human synovial fluid in rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20130961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The crystal structure of the H48Q active site mutant of human group IIA secreted phospholipase A2 at 1.5 A resolution provides an insight into the catalytic mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/20130961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple-docking and affinity fingerprint methods for protein classification and inhibitors selection.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20130961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Principles of docking: An overview of search algorithms and a guide to scoring functions

1 reference

https://pubmed.ncbi.nlm.nih.gov/20130961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

X-ray crystal structure determination and molecular dynamics simulation of prophospholipase A2 inhibited by amide-type substrate analogues

1 reference

https://pubmed.ncbi.nlm.nih.gov/20130961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human extracellular recombinant phospholipase A2 induces an inflammatory response in rabbit joints

1 reference

https://pubmed.ncbi.nlm.nih.gov/20130961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibitors of secretory phospholipase A2 group IIA.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20130961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure-based design of the first potent and selective inhibitor of human non-pancreatic secretory phospholipase A2

1 reference

https://pubmed.ncbi.nlm.nih.gov/20130961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for a Ca2+ channel within the ryanodine receptor complex from cardiac sarcoplasmic reticulum

1 reference

https://pubmed.ncbi.nlm.nih.gov/20130961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Docking-based virtual screening: recent developments.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20130961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Principles of docking: An overview of search algorithms and a guide to scoring functions

1 reference

https://pubmed.ncbi.nlm.nih.gov/20130961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S10822-010-9319-7

1 reference

Europe PubMed Central

PubMed publication ID

15 November 2017

DBLP publication ID

journals/jcamd/MouchlisMK10

1 reference

DBLP Dataset 2021-01-02

28 January 2021

Dimensions Publication ID

0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

15 November 2017

ResearchGate publication ID

0 references

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