(Q43224448)

English

Simvastatin activates Akt/glycogen synthase kinase-3beta signal and inhibits caspase-3 activation after experimental subarachnoid hemorrhage

scientific article published on 18 December 2009

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Europe PubMed Central

PubMed publication ID

16 November 2017

Simvastatin activates Akt/glycogen synthase kinase-3beta signal and inhibits caspase-3 activation after experimental subarachnoid hemorrhage (English)

1 reference

Europe PubMed Central

PubMed publication ID

16 November 2017

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author name string

Gao Cheng

1

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Europe PubMed Central

PubMed publication ID

16 November 2017

Wang Chunlei

2

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Europe PubMed Central

PubMed publication ID

16 November 2017

Wu Pei

3

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Europe PubMed Central

PubMed publication ID

16 November 2017

Liu Zhen

4

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Europe PubMed Central

PubMed publication ID

16 November 2017

Liu Xiangzhen

5

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Europe PubMed Central

PubMed publication ID

16 November 2017

publication date

18 December 2009

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16 November 2017

Vascular Pharmacology

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Europe PubMed Central

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16 November 2017

52

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Europe PubMed Central

PubMed publication ID

16 November 2017

1-2

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Europe PubMed Central

PubMed publication ID

16 November 2017

77-83

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Europe PubMed Central

PubMed publication ID

16 November 2017

Mechanism of activation of protein kinase B by insulin and IGF-1

1 reference

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Acute vasoconstriction after subarachnoid hemorrhage

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Mechanisms of early brain injury after subarachnoid hemorrhage

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p53 may play an orchestrating role in apoptotic cell death after experimental subarachnoid hemorrhage

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Atorvastatin ameliorates cerebral vasospasm and early brain injury after subarachnoid hemorrhage and inhibits caspase-dependent apoptosis pathway

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Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

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Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

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Activation of the Akt/GSK3beta signaling pathway mediates survival of vulnerable hippocampal neurons after transient global cerebral ischemia in rats

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7 January 2021

Akt/GSK3beta survival signaling is involved in acute brain injury after subarachnoid hemorrhage in rats

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Experimental model of symptomatic vasospasm in rabbits

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Cytosolic redistribution of cytochrome c after transient focal cerebral ischemia in rats.

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Prevention of experimental cerebral vasospasm by intracranial delivery of a nitric oxide donor from a controlled-release polymer: toxicity and efficacy studies in rabbits and rats

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Anti-apoptotic and neuroprotective effects of Tetramethylpyrazine following subarachnoid hemorrhage in rats

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Role of glycogen synthase kinase-3beta in neuronal apoptosis induced by trophic withdrawal

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Health-related quality of life after aneurysmal subarachnoid hemorrhage: impacts of bleeding severity, computerized tomography findings, surgery, vasospasm, and neurological grade.

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Statin use was not associated with less vasospasm or improved outcome after subarachnoid hemorrhage

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Contribution of Src tyrosine kinase to cerebral vasospasm after subarachnoid hemorrhage

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Simvastatin attenuates expression of cytokine-inducible nitric-oxide synthase in embryonic cardiac myoblasts.

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Cell death after exposure to subarachnoid hemolysate correlates inversely with expression of CuZn-superoxide dismutase

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7 January 2021

Subarachnoid hemolysate produces DNA fragmentation in a pattern similar to apoptosis in mouse brain

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7 January 2021

Increased cytochrome c-mediated DNA fragmentation and cell death in manganese-superoxide dismutase-deficient mice after exposure to subarachnoid hemolysate.

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7 January 2021

Simvastatin increases endothelial nitric oxide synthase and ameliorates cerebral vasospasm resulting from subarachnoid hemorrhage

1 reference

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7 January 2021

Systemic administration of simvastatin after the onset of experimental subarachnoid hemorrhage attenuates cerebral vasospasm

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7 January 2021

Simvastatin for the prevention of symptomatic cerebral vasospasm following aneurysmal subarachnoid hemorrhage: a single-institution prospective cohort study

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7 January 2021

Prevention of stroke and dementia by statin therapy: experimental and clinical evidence of their pleiotropic effects.

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Evidence of phosphorylation of Akt and neuronal survival after transient focal cerebral ischemia in mice

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Akt phosphorylation and neuronal survival after traumatic brain injury in mice

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Trends over time in the management of subarachnoid haemorrhage in newcastle: review of 1609 patients.

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Mechanisms of hyperbaric oxygen-induced neuroprotection in a rat model of subarachnoid hemorrhage

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Effect of prior statin use on functional outcome and delayed vasospasm after acute aneurysmal subarachnoid hemorrhage: a matched controlled cohort study.

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Neurovascular protection reduces early brain injury after subarachnoid hemorrhage

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Delayed cell death related to acute cerebral blood flow changes following subarachnoid hemorrhage in the rat brain

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Optimal windows of statin use for immediate infarct limitation: 5'-nucleotidase as another downstream molecule of phosphatidylinositol 3-kinase

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7 January 2021

Intracranial aneurysms

1 reference

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Do statins improve outcomes and reduce the incidence of vasospasm after aneurysmal subarachnoid hemorrhage: a meta-analysis

1 reference

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7 January 2021

Simvastatin attenuation of cerebral vasospasm after subarachnoid hemorrhage in rats via increased phosphorylation of Akt and endothelial nitric oxide synthase

1 reference

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7 January 2021

Effects of acute treatment with pravastatin on cerebral vasospasm, autoregulation, and delayed ischemic deficits after aneurysmal subarachnoid hemorrhage: a phase II randomized placebo-controlled trial

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Effects of acute treatment with statins on cerebral autoregulation in patients after aneurysmal subarachnoid hemorrhage.

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Increase in phosphorylation of Akt and its downstream signaling targets and suppression of apoptosis by simvastatin after traumatic brain injury

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Akt/Bad signaling and motor neuron survival after spinal cord injury

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Comparison between one- and two-hemorrhage models of cerebral vasospasm in rabbits

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7 January 2021

Identifiers

10.1016/J.VPH.2009.12.001

1 reference

Europe PubMed Central

PubMed publication ID

16 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

16 November 2017

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