(Q43261458)

English

Decreasing the infusion rate reduces the proarrhythmic risk of NS-7: confirming the relevance of short-term variability of repolarisation in predicting drug-induced torsades de pointes

scientific article published in June 2005

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

17 November 2017

Decreasing the infusion rate reduces the proarrhythmic risk of NS-7: confirming the relevance of short-term variability of repolarisation in predicting drug-induced torsades de pointes (English)

1 reference

Europe PubMed Central

PMC publication ID

17 November 2017

Morten B Thomsen

2

1 reference

Europe PubMed Central

PMC publication ID

17 November 2017

author name string

Elke Detre

1

1 reference

Europe PubMed Central

PMC publication ID

17 November 2017

Jet D Beekman

3

1 reference

Europe PubMed Central

PMC publication ID

17 November 2017

Karl-Uwe Petersen

4

1 reference

Europe PubMed Central

PMC publication ID

17 November 2017

Marc A Vos

5

1 reference

Europe PubMed Central

PMC publication ID

17 November 2017

language of work or name

0 references

publication date

1 June 2005

1 reference

Europe PubMed Central

PMC publication ID

17 November 2017

British Journal of Pharmacology

1 reference

Europe PubMed Central

PMC publication ID

17 November 2017

145

1 reference

Europe PubMed Central

PMC publication ID

17 November 2017

3

1 reference

Europe PubMed Central

PMC publication ID

17 November 2017

397-404

1 reference

Europe PubMed Central

PMC publication ID

17 November 2017

Increased short-term variability of repolarization predicts d-sotalol-induced torsades de pointes in dogs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576153

25 May 2018

Electrophysiological effects of ranolazine, a novel antianginal agent with antiarrhythmic properties

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576153

25 May 2018

Drug-induced prolongation of the QT interval

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576153

25 May 2018

Assessing predictors of drug-induced torsade de pointes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576153

25 May 2018

Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576153

25 May 2018

Interaction of different potassium channels in cardiac repolarization in dog ventricular preparations: role of repolarization reserve

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576153

25 May 2018

Cellular mechanisms underlying the long QT syndrome.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576153

25 May 2018

Chronic amiodarone evokes no torsade de pointes arrhythmias despite QT lengthening in an animal model of acquired long-QT syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576153

25 May 2018

Azimilide and dofetilide produce similar electrophysiological and proarrhythmic effects in a canine model of Torsade de Pointes arrhythmias

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576153

25 May 2018

Effective plasma concentration of a novel Na+/Ca2+ channel blocker NS-7 for its cerebroprotective actions in rats with a transient middle cerebral artery occlusion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576153

25 May 2018

Na+ and high-voltage-activated Ca2+ channel blocking actions of NS-7, a novel neuroprotective agent, in NG108-15 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576153

25 May 2018

An improved method to correct the QT interval of the electrocardiogram for changes in heart rate.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576153

25 May 2018

A subpopulation of cells with unique electrophysiological properties in the deep subepicardium of the canine ventricle. The M cell

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576153

25 May 2018

Arrhythmogenic activities of antiarrhythmic drugs in conscious hypokalemic dogs with atrioventricular block: comparison between quinidine, lidocaine, flecainide, propranolol and sotalol.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576153

25 May 2018

The potential for QT prolongation and pro-arrhythmia by non-anti-arrhythmic drugs: clinical and regulatory implications. Report on a Policy Conference of the European Society of Cardiology.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576153

16 June 2018

In vivo experimental approach for the risk assessment of fluoroquinolone antibacterial agents-induced long QT syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576153

15 August 2018

Electrophysiological safety of sertindole in dogs with normal and remodeled hearts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576153

15 August 2018

Cisapride-induced transmural dispersion of repolarization and torsade de pointes in the canine left ventricular wedge preparation during epicardial stimulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576153

15 August 2018

Neuroprotective effects of NS-7, voltage-gated Na+/Ca2+ channel blocker in a rodent model of transient focal ischaemia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576153

15 August 2018

Neuroprotective effect of NS-7, a novel Na+ and Ca2+ channel blocker, in a focal ischemic model in the rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576153

15 August 2018

Cardiac electrophysiological modulation by NS-7, a novel neuroprotective drug, of guinea pig ventricular muscles

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576153

15 August 2018

Divergent proarrhythmic potential of macrolide antibiotics despite similar QT prolongation: fast phase 3 repolarization prevents early afterdepolarizations and torsade de pointes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576153

15 August 2018

Calmodulin inhibitor W-7 unmasks a novel electrocardiographic parameter that predicts initiation of torsade de pointes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576153

15 August 2018

A novel voltage-sensitive Na(+) and Ca(2+) channel blocker, NS-7, prevents suppression of cyclic AMP-dependent protein kinase and reduces infarct area in the acute phase of cerebral ischemia in rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576153

15 August 2018

Electrophysiological and neurochemical evidence for voltage-dependent Ca(2+) channel blockade by a novel neuroprotective agent NS-7.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576153

15 August 2018

Electrophysiological parameters indicative of sudden cardiac death in the dog with chronic complete AV-block

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576153

15 August 2018

Evaluation of the acute electrophysiologic effects of intravenous dronedarone, an amiodarone-like agent, with special emphasis on ventricular repolarization and acquired torsade de pointes arrhythmias.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576153

15 August 2018

Enhanced susceptibility for acquired torsade de pointes arrhythmias in the dog with chronic, complete AV block is related to cardiac hypertrophy and electrical remodeling

1 reference

https://pubmed.ncbi.nlm.nih.gov/15778734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of blockade of voltage-sensitive Ca(2+)/Na(+) channels by a novel phenylpyrimidine derivative, NS-7, on CREB phosphorylation in focal cerebral ischemia in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/15778734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Temporal repolarization lability differences among genotyped patients with the long QT syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/15778734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Instability and triangulation of the action potential predict serious proarrhythmia, but action potential duration prolongation is antiarrhythmic

1 reference

https://pubmed.ncbi.nlm.nih.gov/15778734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Systemic administration of calmodulin antagonist W-7 or protein kinase A inhibitor H-8 prevents torsade de pointes in rabbits

1 reference

https://pubmed.ncbi.nlm.nih.gov/15778734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Further observations to elucidate the role of interventricular dispersion of repolarization and early afterdepolarizations in the genesis of acquired torsade de pointes arrhythmias: a comparison between almokalant and d-sotalol using the dog as its

1 reference

https://pubmed.ncbi.nlm.nih.gov/15778734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Taking the "idio" out of "idiosyncratic": predicting torsades de pointes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15778734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preferential inhibition by a novel Na(+)/Ca(2+) channel blocker NS-7 of severe to mild hypoxic injury in rat cerebrocortical slices: A possible involvement of a highly voltage-dependent blockade of Ca(2+) channel

1 reference

https://pubmed.ncbi.nlm.nih.gov/15778734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase 2 prolongation, in the absence of instability and triangulation, antagonizes class III proarrhythmia

1 reference

https://pubmed.ncbi.nlm.nih.gov/15778734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proarrhythmic effects of the class III agent almokalant: importance of infusion rate, QT dispersion, and early afterdepolarisations

1 reference

https://pubmed.ncbi.nlm.nih.gov/15778734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/SJ.BJP.0706203

1 reference

Europe PubMed Central

PMC publication ID

17 November 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 November 2017

ResearchGate publication ID

0 references

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