(Q43262474)

17 November 2017

Identification of the active metabolite of ticlopidine from rat in vitro metabolites (English)

1 reference

17 November 2017

Kenji Yoneda

1

1 reference

17 November 2017

Ryou Iwamura

2

1 reference

17 November 2017

Hiroko Kishi

3

1 reference

17 November 2017

Yoichi Mizukami

4

1 reference

17 November 2017

Kimiko Mogami

5

1 reference

17 November 2017

Sei Kobayashi

6

1 reference

17 November 2017

language of work or name

English

0 references

publication date

17 May 2004

1 reference

British Journal of Pharmacology

17 November 2017

1 reference

17 November 2017

142

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17 November 2017

3

1 reference

17 November 2017

551-557

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Inactivation of the human P2Y12 receptor by thiol reagents requires interaction with both extracellular cysteine residues, Cys17 and Cys270.

17 November 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574971

The metabolism of clopidogrel is catalyzed by human cytochrome P450 3A and is inhibited by atorvastatin

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574971

Structure and stereochemistry of the active metabolite of clopidogrel

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574971

Molecular identification and characterization of the platelet ADP receptor targeted by thienopyridine antithrombotic drugs

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574971

Identification of the platelet ADP receptor targeted by antithrombotic drugs

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574971

Antiplatelet action of R-99224, an active metabolite of a novel thienopyridine-type G(i)-linked P2T antagonist, CS-747

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574971

ADP is the cognate ligand for the orphan G protein-coupled receptor SP1999

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574971

The in vivo pharmacological profile of CS-747, a novel antiplatelet agent with platelet ADP receptor antagonist properties

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574971

ADP can induce aggregation of human platelets via both P2Y(1) and P(2T) receptors

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574971

Ticlopidine and clopidogrel

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574971

Coactivation of two different G protein-coupled receptors is essential for ADP-induced platelet aggregation

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574971

Molecular basis for ADP-induced platelet activation. I. Evidence for three distinct ADP receptors on human platelets

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574971

Ticlopidine hydrochloride: Relationship between dose, kinetics, plasma concentration and effect on platelet function

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574971

Ticlopidine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in platelet-dependent disease states

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574971

Functionally thrombasthenic state in normal platelets following the administration of ticlopidine

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574971

A randomized trial comparing ticlopidine hydrochloride with aspirin for the prevention of stroke in high-risk patients. Ticlopidine Aspirin Stroke Study Group

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574971

The Canadian American Ticlopidine Study (CATS) in thromboembolic stroke

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574971

Anti-thrombotic action of ticlopidine, a new platelet aggregation inhibitor

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574971

P2y(12), a new platelet ADP receptor, target of clopidogrel

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574971

ADP receptors of platelets and their inhibition

15 August 2018

1 reference

12 December 2020

Effect of ticlopidine on human platelet responsiveness ex vivo: comparison with aspirin

1 reference

12 December 2020

Effect of ticlopidine on platelet aggregation, adherence to damaged vessels, thrombus formation and platelet survival

1 reference

12 December 2020

Ticlopidine selectively inhibits human platelet responses to adenosine diphosphate

1 reference

12 December 2020

Importance of hepatic metabolism in the antiaggregating activity of the thienopyridine clopidogrel

1 reference

12 December 2020

The antiaggregating activity of clopidogrel is due to a metabolic activation by the hepatic cytochrome P450-1A

1 reference

12 December 2020

Evidence for two distinct G-protein-coupled ADP receptors mediating platelet activation

1 reference

12 December 2020

Identification and biological activity of the active metabolite of clopidogrel

1 reference

12 December 2020

Identifiers

DOI

10.1038/SJ.BJP.0705808

1 reference

17 November 2017

1 reference

17 November 2017

PubMed publication ID

15148251

1 reference