(Q43273249)

18 November 2017

title

Neuroprotective effect of KB-R7943 against glutamate excitotoxicity is related to mild mitochondrial depolarization (English)

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18 November 2017

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T P Storozhevykh

1

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18 November 2017

Ya E Senilova

2

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18 November 2017

T Brustovetsky

3

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18 November 2017

V G Pinelis

4

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18 November 2017

N Brustovetsky

5

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18 November 2017

publication date

22 September 2009

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18 November 2017

published in

Neurochemical Research

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18 November 2017

volume

35

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18 November 2017

issue

2

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18 November 2017

page(s)

323-335

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Mitochondria control ampa/kainate receptor-induced cytoplasmic calcium deregulation in rat cerebellar granule cells.

18 November 2017

cites work

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12 December 2020

The novel Na+/Ca2+ exchange inhibitor KB-R7943 protects CA1 neurons in rat hippocampal slices against hypoxic/hypoglycemic injury

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12 December 2020

Glutamate impairs neuronal calcium extrusion while reducing sodium gradient

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12 December 2020

Calcium-induced cytochrome c release from CNS mitochondria is associated with the permeability transition and rupture of the outer membrane

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12 December 2020

Reverse mode Na+/Ca2+ exchangers trigger the release of Ca2+ from intracellular Ca2+ stores in cultured rat embryonic cortical neurons

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12 December 2020

Oligomeric BAX induces mitochondrial permeability transition and complete cytochrome c release without oxidative stress

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12 December 2020

Secondary Ca2+ overload indicates early neuronal injury which precedes staining with viability indicators.

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12 December 2020

A novel isothiourea derivative selectively inhibits the reverse mode of Na+/Ca2+ exchange in cells expressing NCX1

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12 December 2020

Preventing NAD(+) depletion protects neurons against excitotoxicity: bioenergetic effects of mild mitochondrial uncoupling and caloric restriction

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12 December 2020

Brain edema induced by in vitro ischemia: causal factors and neuroprotection

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12 December 2020

Na(+) and Ca(2+) homeostasis pathways, cell death and protection after oxygen-glucose-deprivation in organotypic hippocampal slice cultures

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12 December 2020

Effects of Na+-Ca2+ exchanger activity on the alpha-amino-3-hydroxy-5-methyl-4-isoxazolone-propionate-induced Ca2+ influx in cerebellar Purkinje neurons

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12 December 2020

Na+/Ca2+ exchange as a drug target--insights from molecular pharmacology and genetic engineering

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12 December 2020

Imaging the permeability pore transition in single mitochondria

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12 December 2020

Role of uncoupled and non-coupled oxidations in maintenance of safely low levels of oxygen and its one-electron reductants

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12 December 2020

Pharmacology of KB-R7943: a Na+-Ca2+ exchange inhibitor.

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12 December 2020

Li+ protects nerve cells against destabilization of Ca2+ homeostasis and delayed death caused by removal of external Na+

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12 December 2020

Important role of reverse Na(+)-Ca(2+) exchange in spinal cord white matter injury at physiological temperature

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12 December 2020

Differential contribution of plasmalemmal Na/Ca exchange isoforms to sodium-dependent calcium influx and NMDA excitotoxicity in depolarized neurons.

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12 December 2020

KB-R7943 inhibits store-operated Ca(2+) entry in cultured neurons and astrocytes.

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12 December 2020

A reevaluation of the role of mitochondria in neuronal Ca2+ homeostasis

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12 December 2020

Contribution of Na(+)/Ca(2+) exchange to excessive Ca(2+) loading in dendrites and somata of CA1 neurons in acute slice

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12 December 2020

The plasma membrane Na+/Ca2+ exchange inhibitor KB-R7943 is also a potent inhibitor of the mitochondrial Ca2+ uniporter.

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12 December 2020

Lithium desensitizes brain mitochondria to calcium, antagonizes permeability transition, and diminishes cytochrome C release

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12 December 2020

Protection of ischemic rat spinal cord white matter: Dual action of KB-R7943 on Na+/Ca2+ exchange and L-type Ca2+ channels

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12 December 2020

Mechanical strain injury increases intracellular sodium and reverses Na+/Ca2+ exchange in cortical astrocytes

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12 December 2020

Glutamate-induced neuron death requires mitochondrial calcium uptake

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12 December 2020

Ionic mechanisms of anoxic injury in mammalian CNS white matter: role of Na+ channels and Na(+)-Ca2+ exchanger.

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12 December 2020

Topics on the Na+/Ca2+ exchanger: pharmacological characterization of Na+/Ca2+ exchanger inhibitors

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12 December 2020

Reverse Na+/Ca2+ exchange contributes to glutamate-induced intracellular Ca2+ concentration increases in cultured rat forebrain neurons

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12 December 2020

Mitochondria are morphologically and functionally heterogeneous within cells.

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12 December 2020

Critical role of sodium in cytosolic [Ca2+] elevations in cultured hippocampal CA1 neurons during anoxic depolarization

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12 December 2020

Uncoupling: new approaches to an old problem of bioenergetics

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12 December 2020

Mitochondrial transport of cations: channels, exchangers, and permeability transition.

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12 December 2020

The leading role of mitochondrial depolarization in the mechanism of glutamate-induced disruptions in Ca2+ homeostasis.

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12 December 2020

Mitochondrial control of acute glutamate excitotoxicity in cultured cerebellar granule cells.

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12 December 2020

Na+/Ca2+ exchange and regulation of cytoplasmic concentration of calcium in rat cerebellar neurons treated with glutamate.

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12 December 2020

The Na+/Ca2+ exchange inhibitor KB-R7943 potently blocks TRPC channels.

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12 December 2020

Changes in calcium dynamics following the reversal of the sodium-calcium exchanger have a key role in AMPA receptor-mediated neurodegeneration via calpain activation in hippocampal neurons

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12 December 2020

Properties of AMPA receptors expressed in rat cerebellar granule cell cultures: Ca2+ influx studies

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12 December 2020

Protection against ischemic brain injury by inhibition of mitochondrial oxidative stress

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12 December 2020

The optimal dosage and window of opportunity to maintain mitochondrial homeostasis following traumatic brain injury using the uncoupler FCCP.

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12 December 2020

Exporting calcium from cells

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12 December 2020

Direction-independent block of bi-directional Na+/Ca2+ exchange current by KB-R7943 in guinea-pig cardiac myocytes

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12 December 2020

Inhibition of different pathways influencing Na(+) homeostasis protects organotypic hippocampal slice cultures from hypoxic/hypoglycemic injury.

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12 December 2020

The difference between mechanisms of kainate and glutamate excitotoxicity in vitro: osmotic lesion versus mitochondrial depolarization

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12 December 2020

In depolarized and glucose-deprived neurons, Na+ influx reverses plasmalemmal K+-dependent and K+-independent Na+/Ca2+ exchangers and contributes to NMDA excitotoxicity

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12 December 2020

Increased tolerance to ischemic neuronal damage by knockdown of Na+-Ca2+ exchanger isoform 1

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12 December 2020

SEA0400, a novel and selective inhibitor of the Na+-Ca2+ exchanger, attenuates reperfusion injury in the in vitro and in vivo cerebral ischemic models.

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12 December 2020

Blockade of NMDA channels in acutely isolated rat hippocampal neurons by the Na+/Ca2+ exchange inhibitor KB-R7943.

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12 December 2020

Sodium/calcium exchange: its physiological implications

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12 December 2020

Role of Na+-K+-Cl- cotransport and Na+/Ca2+ exchange in mitochondrial dysfunction in astrocytes following in vitro ischemia

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12 December 2020

Measurements of mitochondrial pH in cultured cortical neurons clarify contribution of mitochondrial pore to the mechanism of glutamate-induced delayed Ca2+ deregulation

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12 December 2020

10.1007/S11064-009-0058-X

Identifiers

DOI

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Dimensions Publication ID

18 November 2017

1012229830

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