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F-box and WD repeat domain containing 7
mammalian protein found in Rattus norvegicus
F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
Fbxw7
F-box and WD-40 domain protein 7
F-box/WD repeat-containing protein 7
In more languages
edit
Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
17 November 2021
UniProt protein ID
D3Z902
subclass of
protein
1 reference
stated in
UniProt
retrieved
25 October 2017
UniProt protein ID
D3Z902
part of
WD40/YVTN repeat-like-containing domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/D3Z902
WD40-repeat-containing domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/D3Z902
F-box-like domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/D3Z902
F-box protein
1 reference
based on heuristic
inferred from protein domain or family
WD40 repeat, protein family
1 reference
based on heuristic
inferred from protein domain or family
WD40 repeat, conserved site, protein family
1 reference
based on heuristic
inferred from protein domain or family
G-protein beta WD-40 repeat, protein family
1 reference
based on heuristic
inferred from protein domain or family
found in taxon
brown rat
1 reference
stated in
UniProt
retrieved
17 November 2021
UniProt protein ID
D3Z902
encoded by
Fbxw7
1 reference
stated in
UniProt
retrieved
17 November 2021
UniProt protein ID
D3Z902
molecular function
ubiquitin binding
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D3Z902
determination method
IBA
cyclin binding
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D3Z902
determination method
IEA
protein-macromolecule adaptor activity
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D3Z902
determination method
IEA
ubiquitin protein ligase binding
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D3Z902
determination method
IEA
identical protein binding
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D3Z902
determination method
IEA
phosphothreonine residue binding
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D3Z902
determination method
IEA
ubiquitin-protein transferase activator activity
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D3Z902
determination method
IEA
cell component
nucleus
determination method
IEA
1 reference
retrieved
27 March 2018
stated in
GOA
curator
UniProt
UniProt protein ID
D3Z902
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=D3Z902&geneProductId=UniProtKB:D3Z902
determination method
IEA
nucleus
determination method
IBA
IEA
3 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
D3Z902
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D3Z902
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D3Z902
determination method
IEA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D3Z902
determination method
IBA
nucleolus
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D3Z902
determination method
IEA
cytoplasm
determination method
IBA
1 reference
retrieved
10 September 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=D3Z902&geneProductId=UniProtKB:D3Z902
determination method
IBA
mitochondrion
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D3Z902
determination method
IEA
endoplasmic reticulum
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D3Z902
determination method
IEA
Golgi apparatus
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D3Z902
determination method
IEA
perinuclear region of cytoplasm
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D3Z902
determination method
IEA
cytoplasm
determination method
IBA
IEA
2 references
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D3Z902
determination method
IEA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D3Z902
determination method
IBA
SCF ubiquitin ligase complex
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D3Z902
determination method
IEA
Parkin-FBXW7-Cul1 ubiquitin ligase complex
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D3Z902
determination method
IEA
biological process
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
determination method
ISS
1 reference
retrieved
27 March 2018
stated in
The Fbw7 tumor suppressor regulates nuclear factor E2-related factor 1 transcription factor turnover through proteasome-mediated proteolysis
GOA
curator
UniProt
UniProt protein ID
D3Z902
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=D3Z902&geneProductId=UniProtKB:D3Z902
determination method
ISS
vasculogenesis
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D3Z902
determination method
IEA
Notch signaling pathway
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D3Z902
determination method
IEA
ubiquitin recycling
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D3Z902
determination method
IBA
lung development
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D3Z902
determination method
IEA
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
determination method
IEA
ISS
2 references
retrieved
8 April 2019
stated in
The Fbw7 tumor suppressor regulates nuclear factor E2-related factor 1 transcription factor turnover through proteasome-mediated proteolysis
GOA
curator
UniProt
UniProt protein ID
D3Z902
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D3Z902
determination method
ISS
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D3Z902
determination method
IEA
protein destabilization
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D3Z902
determination method
IEA
proteasome-mediated ubiquitin-dependent protein catabolic process
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D3Z902
determination method
IBA
regulation of cell migration involved in sprouting angiogenesis
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D3Z902
determination method
IEA
positive regulation of proteasomal protein catabolic process
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D3Z902
determination method
IEA
negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D3Z902
determination method
IEA
positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D3Z902
determination method
IEA
negative regulation of osteoclast development
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D3Z902
determination method
IEA
sister chromatid cohesion
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D3Z902
determination method
IEA
negative regulation of gene expression
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D3Z902
determination method
IEA
protein ubiquitination
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D3Z902
determination method
IEA
positive regulation of protein ubiquitination
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D3Z902
determination method
IEA
negative regulation of DNA endoreduplication
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D3Z902
determination method
IEA
positive regulation of epidermal growth factor-activated receptor activity
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D3Z902
determination method
IEA
protein stabilization
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D3Z902
determination method
IEA
positive regulation of ubiquitin-protein transferase activity
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D3Z902
determination method
IEA
positive regulation of ERK1 and ERK2 cascade
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D3Z902
determination method
IEA
regulation of autophagy of mitochondrion
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D3Z902
determination method
IEA
positive regulation of protein targeting to mitochondrion
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D3Z902
determination method
IEA
positive regulation of ubiquitin-dependent protein catabolic process
determination method
IEA
1 reference
retrieved
14 January 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=D3Z902&geneProductId=UniProtKB:D3Z902
determination method
IEA
regulation of circadian rhythm
determination method
IEA
ISS
2 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
D3Z902
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D3Z902
determination method
ISS
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D3Z902
determination method
IEA
positive regulation of ubiquitin-dependent protein catabolic process
determination method
IEA
ISS
2 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
D3Z902
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D3Z902
determination method
ISS
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D3Z902
determination method
IEA
rhythmic process
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
D3Z902
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:D3Z902
determination method
IEA
has part(s)
WD40 repeat
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/D3Z902
WD40 repeat, conserved site
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/D3Z902
G-protein beta WD-40 repeat
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/D3Z902
F-box domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/D3Z902
Identifiers
RefSeq protein ID
XP_003749359
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
100360914
XP_006232617
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
100360914
XP_038959666
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
100360914
XP_038959667
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
100360914
XP_038959668
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
100360914
XP_038959669
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
100360914
XP_038959670
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
100360914
XP_038959671
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
100360914
XP_038959672
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
100360914
UniProt protein ID
D3Z902
1 reference
stated in
UniProt
retrieved
17 November 2021
UniProt protein ID
D3Z902
Ensembl protein ID
ENSRNOP00000074892
1 reference
stated in
ensembl Release 106
Ensembl protein ID
ENSRNOP00000074892
ENSRNOP00000015280
1 reference
stated in
ensembl Release 106
Ensembl protein ID
ENSRNOP00000015280
ENSRNOP00000050193
1 reference
stated in
ensembl Release 106
Ensembl protein ID
ENSRNOP00000050193
ENSRNOP00000090758
1 reference
stated in
ensembl Release 106
Ensembl protein ID
ENSRNOP00000090758
Sitelinks
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