(Q43467884)

23 November 2017

title

Synthesis and biological assessment of simplified analogues of the potent microtubule stabilizer (+)-discodermolide (English)

1 reference

23 November 2017

José M Mínguez

1

1 reference

23 November 2017

Sun-Young Kim

2

1 reference

23 November 2017

Kenneth A Giuliano

3

1 reference

23 November 2017

Raghavan Balachandran

4

1 reference

23 November 2017

Charitha Madiraju

5

1 reference

23 November 2017

Billy W Day

6

1 reference

23 November 2017

Dennis P Curran

7

1 reference

23 November 2017

language of work or name

English

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publication date

1 July 2003

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Bioorganic & Medicinal Chemistry

23 November 2017

published in

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23 November 2017

volume

11

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23 November 2017

issue

15

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23 November 2017

page(s)

3335-3357

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Discodermolide: a new bioactive polyhydroxylated lactone from the marine sponge Discodermia dissoluta

23 November 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900186-X

7 January 2021

Solution structure of (+)-discodermolide

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900186-X

7 January 2021

The conformations of discodermolide in DMSO.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900186-X

7 January 2021

Immunosuppressive compounds from a deep water marine sponge, Agelas flabelliformis

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900186-X

7 January 2021

Discodermolide, a cytotoxic marine agent that stabilizes microtubules more potently than taxol

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900186-X

7 January 2021

(+)-Discodermolide binds to microtubules in stoichiometric ratio to tubulin dimers, blocks taxol binding and results in mitotic arrest

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900186-X

7 January 2021

The potent microtubule-stabilizing agent (+)-discodermolide induces apoptosis in human breast carcinoma cells--preliminary comparisons to paclitaxel.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900186-X

7 January 2021

The epothilones, eleutherobins, and related types of molecules

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900186-X

7 January 2021

Gram-scale synthesis of (+)-discodermolide

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900186-X

7 January 2021

Total Synthesis of the Antimicrotubule Agent (+)-Discodermolide Using Boron-Mediated Aldol Reactions of Chiral Ketones

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900186-X

7 January 2021

A practical synthesis of (+)-discodermolide and analogues: fragment union by complex aldol reactions

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900186-X

7 January 2021

Acetylated analogues of the microtubule-stabilizing agent discodermolide: preparation and biological activity

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900186-X

7 January 2021

Activated Dimethyl Sulfoxide: Useful Reagents for Synthesis

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900186-X

7 January 2021

Readily accessible 12-I-5 oxidant for the conversion of primary and secondary alcohols to aldehydes and ketones

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900186-X

7 January 2021

A useful 12-I-5 triacetoxyperiodinane (the Dess-Martin periodinane) for the selective oxidation of primary or secondary alcohols and a variety of related 12-I-5 species

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900186-X

7 January 2021

Regio- and stereo-selective reactions of trimethylsilyl-substituted allyl-chromium reagents with aldehydes

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900186-X

7 January 2021

Separation of active tubulin and microtubule-associated proteins by ultracentrifugation and isolation of a component causing the formation of microtubule bundles.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900186-X

7 January 2021

The microtubule-stabilizing agent discodermolide competitively inhibits the binding of paclitaxel (Taxol) to tubulin polymers, enhances tubulin nucleation reactions more potently than paclitaxel, and inhibits the growth of paclitaxel-resistant cells

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900186-X

7 January 2021

Synthesis and biological evaluation of structurally highly modified analogues of the antimitotic natural product curacin A.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900186-X

7 January 2021

Asymmetric synthesis using diisopropyl tartrate modified (E)- and (Z)-crotylboronates: preparation of the chiral crotylboronates and reactions with achiral aldehydes

1 reference

19 October 2022

https://opencitations.net/index/coci/api/v1/citations/10.1021/JA00173A023

Identifiers

DOI

10.1016/S0968-0896(03)00186-X

1 reference

23 November 2017

1 reference