(Q43470687)

English

A double-blind, placebo-controlled, crossover therapy study with natural human IL-2 (nhuIL-2) in combination with regular intravenous gammaglobulin (IVIG) infusions in 10 patients with common variable immunodeficiency (CVID).

scientific article published in November 1997

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

23 November 2017

A double-blind, placebo-controlled, crossover therapy study with natural human IL-2 (nhuIL-2) in combination with regular intravenous gammaglobulin (IVIG) infusions in 10 patients with common variable immunodeficiency (CVID). (English)

1 reference

Europe PubMed Central

PubMed publication ID

23 November 2017

1 reference

based on heuristic

inferred from title

common variable immunodeficiency

1 reference

based on heuristic

inferred from title

author name string

J A Rump

1

1 reference

Europe PubMed Central

PubMed publication ID

23 November 2017

A Jahreis

2

1 reference

Europe PubMed Central

PubMed publication ID

23 November 2017

M Schlesier

3

1 reference

Europe PubMed Central

PubMed publication ID

23 November 2017

S Stecher

4

1 reference

Europe PubMed Central

PubMed publication ID

23 November 2017

H H Peter

5

1 reference

Europe PubMed Central

PubMed publication ID

23 November 2017

publication date

1 November 1997

1 reference

Europe PubMed Central

PubMed publication ID

23 November 2017

Clinical and Experimental Immunology

1 reference

Europe PubMed Central

PubMed publication ID

23 November 2017

110

1 reference

Europe PubMed Central

PubMed publication ID

23 November 2017

2

1 reference

Europe PubMed Central

PubMed publication ID

23 November 2017

167-173

1 reference

Europe PubMed Central

PubMed publication ID

23 November 2017

Antigen presentation by common variable immunodeficiency (CVID) B cells and monocytes is unimpaired.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265503

27 August 2018

Failure in antigen responses by T cells from patients with common variable immunodeficiency (CVID).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265503

27 August 2018

A defect in the early phase of T-cell receptor-mediated T-cell activation in patients with common variable immunodeficiency.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265503

27 August 2018

Activated B cells from patients with common variable immunodeficiency proliferate and synthesize immunoglobulin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265503

27 August 2018

CD40 ligand expression is defective in a subset of patients with common variable immunodeficiency

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265503

27 August 2018

Three distinct stages of B-cell defects in common varied immunodeficiency.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265503

27 August 2018

Interleukin-2: inception, impact, and implications

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265503

27 August 2018

Failure of B cells in common variable immunodeficiency to transit from proliferation to differentiation is associated with altered B cell surface-molecule display

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265503

27 August 2018

The role of lymphokines in common variable hypogammaglobulinemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265503

27 August 2018

Pleiotropy and redundancy: T cell-derived lymphokines in the immune response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265503

27 August 2018

Cellular abnormalities in common variable immunodeficiency

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265503

27 August 2018

Defects in proliferative responses of T cells from patients with common variable immunodeficiency on direct activation of protein kinase C

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265503

27 August 2018

Restoration of immunoglobulin secretion in vitro in common variable immunodeficiency by in vivo treatment with polyethylene glycol-conjugated human recombinant interleukin-2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265503

27 August 2018

Regulation of the interleukin-2 gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265503

27 August 2018

Immunophenotypical alterations in a subset of patients with common variable immunodeficiency (CVID)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265503

27 August 2018

Peripheral blood lymphocytes of patients with common variable immunodeficiency (CVI) produce reduced levels of interleukin-4, interleukin-2 and interferon-gamma, but proliferate normally upon activation by mitogens

1 reference

https://pubmed.ncbi.nlm.nih.gov/9367398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced interleukin-2 (IL-2) production in common variable immunodeficiency is due to a primary abnormality of CD4+ T cell differentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/9367398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ligation of leukocyte function-associated (LFA) molecule-1 provides an accessory signal for T-cell activation with pokeweed mitogen

1 reference

https://pubmed.ncbi.nlm.nih.gov/9367398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Co-stimulation with anti-CD28 (Kolt-2) enhances DNA synthesis by defective T cells in common variable immunodeficiency

1 reference

https://pubmed.ncbi.nlm.nih.gov/9367398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The costimulatory signal CD28 is fully functional but cannot correct the impaired antigen response in T cells of patients with common variable immunodeficiency

1 reference

https://pubmed.ncbi.nlm.nih.gov/9367398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-CD28 enhances defective mitogen responses by mononuclear cells from patients with common variable immunodeficiency

1 reference

https://pubmed.ncbi.nlm.nih.gov/9367398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potential uses of polyethylene glycol conjugated recombinant IL-2 in common variable immunodeficiency

1 reference

https://pubmed.ncbi.nlm.nih.gov/9367398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of IL-2 on immunoglobulin production by anti-CD40-activated human B cells: synergistic effect with IL-10 and antagonistic effect with IL-4

1 reference

https://pubmed.ncbi.nlm.nih.gov/9367398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brief report: enhanced humoral immunity in common variable immunodeficiency after long-term treatment with polyethylene glycol-conjugated interleukin-2

1 reference

https://pubmed.ncbi.nlm.nih.gov/9367398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced IL-2 expression upon antigen stimulation is accompanied by deficient IL-9 gene expression in T cells of patients with CVID

1 reference

https://pubmed.ncbi.nlm.nih.gov/9367398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Defects in antigen-driven lymphocyte responses in common variable immunodeficiency (CVID) are due to a reduction in the number of antigen-specific CD4+ T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/9367398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alterations in interleukin secretion (IL-2 and IL-4) by CD4 and CD4 CD45RO cells from common variable immunodeficiency (CVI) patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/9367398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transient CD80 expression defect in a patient with variable immunodeficiency and cyclic neutropenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/9367398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-4 synergizes with IL-10 and anti-CD40 MoAbs to induce B-cell differentiation in patients with common variable immunodeficiency

1 reference

https://pubmed.ncbi.nlm.nih.gov/9367398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Low-dose interleukin-2 induces systemic immune responses against HBsAg in immunodeficient non-responders to hepatitis B vaccination

1 reference

https://pubmed.ncbi.nlm.nih.gov/9367398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

B cell function in acquired "common-variable" hypogammaglobulinemia: proliferative responses to lymphokines

1 reference

https://pubmed.ncbi.nlm.nih.gov/9367398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical and immunologic analyses of 103 patients with common variable immunodeficiency

1 reference

https://pubmed.ncbi.nlm.nih.gov/9367398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Possible role of IL-2 deficiency for hypogammaglobulinaemia in patients with common variable immunodeficiency

1 reference

https://pubmed.ncbi.nlm.nih.gov/9367398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Primary immunodeficiency diseases. Report of a WHO scientific group

1 reference

https://pubmed.ncbi.nlm.nih.gov/9367398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Defective interleukin-2 and interferon-gamma gene expression in response to antigen in a subgroup of patients with common variable immunodeficiency

1 reference

https://pubmed.ncbi.nlm.nih.gov/9367398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Classification of patients with common variable immunodeficiency by B cell secretion of IgM and IgG in response to anti-IgM and interleukin-2

1 reference

https://pubmed.ncbi.nlm.nih.gov/9367398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/J.1365-2249.1997.TB08313.X

1 reference

Europe PubMed Central

PubMed publication ID

23 November 2017

PMC publication ID

0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

23 November 2017

ResearchGate publication ID

0 references

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