(Q43551098)

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Caspase-8 is an effector in apoptotic death of dopaminergic neurons in Parkinson's disease, but pathway inhibition results in neuronal necrosis.

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scholarly article

1 reference

Europe PubMed Central

24 November 2017

Caspase-8 is an effector in apoptotic death of dopaminergic neurons in Parkinson's disease, but pathway inhibition results in neuronal necrosis (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6762382&resulttype=core&format=json

12 May 2020

apoptotic process

0 references

Parkinson's disease

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

Stéphane Hunot

3

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6762382&resulttype=core&format=json

12 May 2020

Etienne C. Hirsch

9

1 reference

Europe PubMed Central

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12 May 2020

author name string

A Hartmann

1

1 reference

Europe PubMed Central

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12 May 2020

J D Troadec

2

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6762382&resulttype=core&format=json

12 May 2020

K Kikly

4

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6762382&resulttype=core&format=json

12 May 2020

B A Faucheux

5

1 reference

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12 May 2020

A Mouatt-Prigent

6

1 reference

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12 May 2020

M Ruberg

7

1 reference

Europe PubMed Central

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12 May 2020

Y Agid

8

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6762382&resulttype=core&format=json

12 May 2020

language of work or name

0 references

publication date

1 April 2001

1 reference

Europe PubMed Central

24 November 2017

Journal of Neuroscience

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6762382&resulttype=core&format=json

12 May 2020

21

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6762382&resulttype=core&format=json

12 May 2020

7

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6762382&resulttype=core&format=json

12 May 2020

2247-2255

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6762382&resulttype=core&format=json

12 May 2020

Evidence for generation of oxidative stress in brain by MPTP: in vitro and in vivo studies in mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11264300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of caspase-like proteinases in apoptosis of neuronal PC12 cells and primary cultured microglia induced by 6-hydroxydopamine

1 reference

https://pubmed.ncbi.nlm.nih.gov/11264300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TUNEL, Hoechst and immunohistochemistry triple-labelling: an improved method for detection of apoptosis in tissue sections--an update

1 reference

https://pubmed.ncbi.nlm.nih.gov/11264300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptotic pathways: the roads to ruin

1 reference

https://pubmed.ncbi.nlm.nih.gov/11264300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor necrosis factor-alpha (TNF-alpha) increases both in the brain and in the cerebrospinal fluid from parkinsonian patients.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11264300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative stress and hypoxia/reoxygenation trigger CD95 (APO-1/Fas) ligand expression in microglial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/11264300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Poly(ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletion

1 reference

https://pubmed.ncbi.nlm.nih.gov/11264300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TUNEL-positive cells in the substantia nigra of C57BL/6 mice after a single bolus of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11264300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1-Methyl-4-phenylpyridinium induces autocrine excitotoxicity, protease activation, and neuronal apoptosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11264300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Energy requirement for caspase activation and neuronal cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/11264300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Parkinson's disease. The apoptosis hypothesis revisited

1 reference

https://pubmed.ncbi.nlm.nih.gov/11264300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caspase inhibition reduces apoptosis and increases survival of nigral transplants.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11264300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Complex I inhibitors induce dose-dependent apoptosis in PC12 cells: relevance to Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/11264300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peptide inhibitors of caspase-3-like proteases attenuate 1-methyl-4-phenylpyridinum-induced toxicity of cultured fetal rat mesencephalic dopamine neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/11264300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The apoptosis-necrosis paradox. Apoptogenic proteases activated after mitochondrial permeability transition determine the mode of cell death.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11264300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner

1 reference

https://pubmed.ncbi.nlm.nih.gov/11264300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rescue of mesencephalic dopamine neurons by anticancer drug cytosine arabinoside.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11264300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Levodopa toxicity and apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/11264300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of a caspase-3-like cysteine protease in 1-methyl-4-phenylpyridinium-mediated apoptosis of cultured cerebellar granule neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11264300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapid cytochrome c release, activation of caspases 3, 6, 7 and 8 followed by Bap31 cleavage in HeLa cells treated with photodynamic therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/11264300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/11264300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuronal apoptosis in acute necrotic insults: why is this subject such a mess?

1 reference

https://pubmed.ncbi.nlm.nih.gov/11264300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Implication of cysteine proteases calpain, cathepsin and caspase in ischemic neuronal death of primates

1 reference

https://pubmed.ncbi.nlm.nih.gov/11264300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Levodopa in the treatment of Parkinson's disease: a consensus meeting

1 reference

https://pubmed.ncbi.nlm.nih.gov/11264300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The parkinsonian neurotoxin MPP+ opens the mitochondrial permeability transition pore and releases cytochrome c in isolated mitochondria via an oxidative mechanism.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11264300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caspase-3: A vulnerability factor and final effector in apoptotic death of dopaminergic neurons in Parkinson's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11264300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caspase-3-like proteases and 6-hydroxydopamine induced neuronal cell death.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11264300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis is induced by 1-methyl-4-phenylpyridinium ion (MPP+) in ventral mesencephalic-striatal co-culture in rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11264300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immature cortical neurons are uniquely sensitive to glutamate toxicity by inhibition of cystine uptake

1 reference

https://pubmed.ncbi.nlm.nih.gov/11264300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of human caspases by peptide-based and macromolecular inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/11264300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dopamine receptor subsensitivity in the substantia nigra after chronic morphine treatment in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/11264300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial respiratory chain disorders II: neurodegenerative disorders and nuclear gene defects

1 reference

https://pubmed.ncbi.nlm.nih.gov/11264300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of T-cell apoptosis: a mixed lymphocyte reaction model

1 reference

https://pubmed.ncbi.nlm.nih.gov/11264300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-4 inhibits apoptosis and prevents mitochondrial damage without inducing the switch to necrosis observed with caspase inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/11264300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracellular ATP levels determine cell death fate by apoptosis or necrosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11264300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis signaling by death receptors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11264300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A predominant apoptotic death pathway of neuronal PC12 cells induced by activated microglia is displaced by a non-apoptotic death pathway following blockage of caspase-3-dependent cascade

1 reference

https://pubmed.ncbi.nlm.nih.gov/11264300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic activation of the cyclic AMP signaling pathway promotes development and long-term survival of mesencephalic dopaminergic neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11264300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

FcepsilonRII/CD23 is expressed in Parkinson's disease and induces, in vitro, production of nitric oxide and tumor necrosis factor-alpha in glial cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11264300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11264300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caspases mediate 6-hydroxydopamine-induced apoptosis but not necrosis in PC12 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/11264300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nuclear translocation of NF-kappaB is increased in dopaminergic neurons of patients with parkinson disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/11264300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dual signaling of the Fas receptor: initiation of both apoptotic and necrotic cell death pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/11264300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caspase-8 and caspase-3 are expressed by different populations of cortical neurons undergoing delayed cell death after focal stroke in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11264300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The glutamate antagonist, MK-801, does not prevent dopaminergic cell death induced by the 1-methyl-4-phenylpyridinium ion (MPP+) in rat dissociated mesencephalic cultures.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11264300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reversible physiological alterations in sympathetic neurons deprived of NGF but protected from apoptosis by caspase inhibition or Bax deletion

1 reference

https://pubmed.ncbi.nlm.nih.gov/11264300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The inflammatory reaction following 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine intoxication in mouse.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11264300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/11264300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunocytochemical analysis of tumor necrosis factor and its receptors in Parkinson's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11264300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A comparative study of apoptosis and necrosis in HepG2 cells: oxidant-induced caspase inactivation leads to necrosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/11264300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotrophins require distinct extracellular signals to promote the survival of CNS neurons in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/11264300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of caspase activity induces a switch from apoptosis to necrosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/11264300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of reactive oxygen intermediates in activation-induced CD95 (APO-1/Fas) ligand expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/11264300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distinct mechanisms underlie neurotoxin-mediated cell death in cultured dopaminergic neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11264300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The causes of Parkinson's disease are being unraveled and rational neuroprotective therapy is close to reality

1 reference

https://pubmed.ncbi.nlm.nih.gov/11264300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In situ detection of apoptotic nuclei in the substantia nigra compacta of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice using terminal deoxynucleotidyl transferase labelling and acridine orange staining

1 reference

https://pubmed.ncbi.nlm.nih.gov/11264300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.21-07-02247.2001

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6762382&resulttype=core&format=json

12 May 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6762382&resulttype=core&format=json

12 May 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6762382&resulttype=core&format=json

12 May 2020

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