(Q43559665)

English

Sphingosine 1-phosphate activates Akt, nitric oxide production, and chemotaxis through a Gi protein/phosphoinositide 3-kinase pathway in endothelial cells

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scholarly article

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Europe PubMed Central

PubMed publication ID

24 November 2017

Sphingosine 1-phosphate activates Akt, nitric oxide production, and chemotaxis through a Gi protein/phosphoinositide 3-kinase pathway in endothelial cells (English)

1 reference

Europe PubMed Central

PubMed publication ID

24 November 2017

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Jean-Philippe Gratton

4

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Europe PubMed Central

PubMed publication ID

24 November 2017

8

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24 November 2017

author name string

Morales-Ruiz M

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24 November 2017

Lee MJ

2

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24 November 2017

Zöllner S

3

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Europe PubMed Central

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24 November 2017

Scotland R

5

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24 November 2017

Shiojima I

6

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Europe PubMed Central

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24 November 2017

Walsh K

7

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24 November 2017

Sessa WC

9

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24 November 2017

language of work or name

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publication date

6 March 2001

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24 November 2017

Journal of Biological Chemistry

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24 November 2017

276

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24 November 2017

22

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24 November 2017

19672-19677

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24 November 2017

Cloning and characterization of a putative G-protein coupled receptor potentially involved in development

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009993200

21 January 2018

Characterization of a novel sphingosine 1-phosphate receptor, Edg-8

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009993200

21 January 2018

EDG1 is a functional sphingosine-1-phosphate receptor that is linked via a Gi/o to multiple signaling pathways, including phospholipase C activation, Ca2+ mobilization, Ras-mitogen-activated protein kinase activation, and adenylate cyclase inhibitio

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009993200

21 January 2018

Sphingosine-1-phosphate, a novel lipid, involved in cellular proliferation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009993200

21 January 2018

Sphingosine 1-phosphate induces angiogenesis: its angiogenic action and signaling mechanism in human umbilical vein endothelial cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009993200

21 January 2018

Sphingosine 1-phosphate stimulates cell migration through a G(i)-coupled cell surface receptor. Potential involvement in angiogenesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009993200

21 January 2018

Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009993200

21 January 2018

Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009993200

21 January 2018

PI3K: downstream AKTion blocks apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009993200

21 January 2018

Mechanisms and consequences of activation of protein kinase B/Akt

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009993200

21 January 2018

Regulation of endothelium-derived nitric oxide production by the protein kinase Akt

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009993200

21 January 2018

Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009993200

21 January 2018

The Akt kinase signals directly to endothelial nitric oxide synthase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009993200

21 January 2018

Akt mediates cytoprotection of endothelial cells by vascular endothelial growth factor in an anchorage-dependent manner

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009993200

21 January 2018

Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3'-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009993200

21 January 2018

Vascular endothelial growth factor up-regulates ICAM-1 expression via the phosphatidylinositol 3 OH-kinase/AKT/Nitric oxide pathway and modulates migration of brain microvascular endothelial cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009993200

21 January 2018

Phosphorylation of the endothelial nitric oxide synthase at ser-1177 is required for VEGF-induced endothelial cell migration

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009993200

21 January 2018

Nitric oxide synthase modulates angiogenesis in response to tissue ischemia

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009993200

21 January 2018

The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009993200

21 January 2018

Endothelial nitric oxide synthase is regulated by tyrosine phosphorylation and interacts with caveolin-1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009993200

21 January 2018

Trafficking of endothelial nitric-oxide synthase in living cells. Quantitative evidence supporting the role of palmitoylation as a kinetic trapping mechanism limiting membrane diffusion.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009993200

21 January 2018

Phosphoinositide 3-kinases: a conserved family of signal transducers

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009993200

21 January 2018

Sphingosine 1-phosphate regulates melanoma cell motility through a receptor-coupled extracellular action and in a pertussis toxin-insensitive manner

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009993200

21 January 2018

Involvement of focal adhesion kinase in inhibition of motility of human breast cancer cells by sphingosine 1-phosphate

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009993200

21 January 2018

Sphingosine 1-phosphate stimulates proliferation and migration of human endothelial cells possibly through the lipid receptors, Edg-1 and Edg-3

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009993200

21 January 2018

Comparison of intrinsic activities of the putative sphingosine 1-phosphate receptor subtypes to regulate several signaling pathways in their cDNA-transfected Chinese hamster ovary cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009993200

21 January 2018

Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009993200

21 January 2018

Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009993200

21 January 2018

Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009993200

21 January 2018

Agonist-modulated targeting of the EDG-1 receptor to plasmalemmal caveolae. eNOS activation by sphingosine 1-phosphate and the role of caveolin-1 in sphingolipid signal transduction.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009993200

21 January 2018

Membrane estrogen receptor engagement activates endothelial nitric oxide synthase via the PI3-kinase-Akt pathway in human endothelial cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009993200

21 January 2018

Phosphorylation and activation of the endothelial nitric oxide synthase by fluid shear stress

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009993200

21 January 2018

Identifiers

10.1074/JBC.M009993200

1 reference

Europe PubMed Central

PubMed publication ID

24 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

24 November 2017

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