(Q43560157)

24 November 2017

title

Thiazolidinediones but not metformin directly inhibit the steroidogenic enzymes P450c17 and 3beta -hydroxysteroid dehydrogenase (English)

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24 November 2017

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1

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24 November 2017

R J Auchus

2

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24 November 2017

W L Miller

series ordinal

3

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24 November 2017

language of work or name

English

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publication date

7 February 2001

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Journal of Biological Chemistry

24 November 2017

published in

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24 November 2017

volume

276

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24 November 2017

issue

20

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24 November 2017

page(s)

16767-16771

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Molecular biology of steroid hormone synthesis

24 November 2017

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100040200

Microsomal cytochrome P-450 from neonatal pig testis: two enzymatic activities (17 alpha-hydroxylase and c17,20-lyase) associated with one protein

21 January 2018

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Expression of bovine 17 alpha-hydroxylase cytochrome P-450 cDNA in nonsteroidogenic (COS 1) cells

21 January 2018

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Molecular endocrinology of hydroxysteroid dehydrogenases

21 January 2018

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Steroid 17 alpha-hydroxylase and 17,20-lyase activities of P450c17: contributions of serine106 and P450 reductase

21 January 2018

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Cytochrome b5 augments the 17,20-lyase activity of human P450c17 without direct electron transfer

21 January 2018

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Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis

21 January 2018

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Metformin therapy in polycystic ovary syndrome reduces hyperinsulinemia, insulin resistance, hyperandrogenemia, and systolic blood pressure, while facilitating normal menses and pregnancy

21 January 2018

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Decreases in ovarian cytochrome P450c17 alpha activity and serum free testosterone after reduction of insulin secretion in polycystic ovary syndrome

21 January 2018

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The insulin-sensitizing agent troglitazone improves metabolic and reproductive abnormalities in the polycystic ovary syndrome.

21 January 2018

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Troglitazone improves defects in insulin action, insulin secretion, ovarian steroidogenesis, and fibrinolysis in women with polycystic ovary syndrome

21 January 2018

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Efficacy of metformin in patients with non-insulin-dependent diabetes mellitus. The Multicenter Metformin Study Group.

21 January 2018

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Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I.

21 January 2018

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Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain

21 January 2018

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PPAR-gamma: adipogenic regulator and thiazolidinedione receptor

21 January 2018

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Roles of PPARs in health and disease.

21 January 2018

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Treatment of insulin resistance with peroxisome proliferator-activated receptor gamma agonists

21 January 2018

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Medroxyprogesterone acetate and dexamethasone are competitive inhibitors of different human steroidogenic enzymes

21 January 2018

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Improved method for high efficiency transformation of intact yeast cells

21 January 2018

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An efficient chloramphenicol-resistance marker for Saccharomyces cerevisiae and Escherichia coli

21 January 2018

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P450c17 mutations R347H and R358Q selectively disrupt 17,20-lyase activity by disrupting interactions with P450 oxidoreductase and cytochrome b5.

21 January 2018

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Cytochrome P450c17 (steroid 17 alpha-hydroxylase/17,20 lyase): cloning of human adrenal and testis cDNAs indicates the same gene is expressed in both tissues

21 January 2018

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Human placental 3 beta-hydroxy-5-ene-steroid dehydrogenase and steroid 5----4-ene-isomerase: purification from mitochondria and kinetic profiles, biophysical characterization of the purified mitochondrial and microsomal enzymes

21 January 2018

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Structure and expression of a new complementary DNA encoding the almost exclusive 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase in human adrenals and gonads

21 January 2018

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Metformin treatment reduces ovarian cytochrome P-450c17alpha response to human chorionic gonadotrophin in women with insulin resistance-related polycystic ovary syndrome.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M100040200

Pharmacokinetics and pharmacodynamics of metformin in healthy subjects and patients with noninsulin-dependent diabetes mellitus

21 January 2018

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Improvement in endocrine and ovarian function during dietary treatment of obese women with polycystic ovary syndrome

21 January 2018

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Effects of diet and metformin administration on sex hormone-binding globulin, androgens, and insulin in hirsute and obese women

21 January 2018

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Steady-state pharmacokinetics and dose proportionality of troglitazone and its metabolites.

21 January 2018

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An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma)

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100040200

The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100040200

Differential activation of peroxisome proliferator-activated receptor-gamma by troglitazone and rosiglitazone

21 January 2018

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Expression and Detection of Inducible Nitric Oxide Synthase in Experimental Models of Inflammation

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M100040200

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24 November 2017

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